Biomedical research.
Publisher:
Biomedical Research Foundation,
Frequency: Six no. a year
Country: Japan
Language: English
Author(s):
Biomedical Research Foundation (Japan)
Start Year:1980 -
Identifiers
| ISSN: | 0388-6107 (Print) 1880-313X (Electronic) 0388-6107 (Linking) |
| NLM ID: | 8100317 |
| (DNLM): | B18490000(s) |
| (OCoLC): | 07111884 |
| Coden: | BRESD5 |
| Classification: | W1 BI856C |
Comparative study of the properties of tendinocytes derived from three different sites in the equine superficial digital flexor tendon. This aim of this study was to determine the characteristic differences in tendinocytes derived from three sites of the equine superficial digital flexor tendon (SDFT)-proximally the myotendinous junction (MTJ), mid-metacarpal (mM) and osteotendinous junction (OTJ)-in morphology, proliferation, and ability for synthesis of collagen and matrix metalloproteinases (MMPs). Little difference was observed in cell proliferation. Addition of tumor necrosis factor (TNF) alpha to the culture medium resulted in increased collagen synthesis by tendinocytes from all three sites. The amount of collagen synth...
Effect of heat on synthesis of gelatinases and pro-inflammatory cytokines in equine tendinocytes. The aim of this study was to clarify whether matrix metalloproteinases (MMP-2 and -9: gelatinases) and pro-inflammatory cytokines [tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta] are induced by heat in tendon tissue in vitro and to test the hypothesis that heat exposure causes tendinocytes to synthesize pro-inflammatory cytokines and that synthesis of these cytokines, in turn, leads to up-regulation of synthesis of gelatinases. Isolated tendinocytes from equine superficial digital flexor tendons were cultured and all experiments were performed on cells passaged 3 or 4 times. In t...