Bone & joint research.
Publisher:
British Editorial Society of Bone & Joint Surgery
Frequency: Monthly
Country: England
Language: English
Author(s):
British Editorial Society of Bone and Joint Surgery.
Start Year:2012 -
Identifiers
| ISSN: | 2046-3758 (Electronic) 2046-3758 (Linking) |
| NLM ID: | 101586057 |
| (OCoLC): | 775524723 |
| LCCN: | 2012243550 |
Increased sclerostin associated with stress fracture of the third metacarpal bone in the Thoroughbred racehorse. The exact aetiology and pathogenesis of microdamage-induced long bone fractures remain unknown. These fractures are likely to be the result of inadequate bone remodelling in response to damage. This study aims to identify an association of osteocyte apoptosis, the presence of osteocytic osteolysis, and any alterations in sclerostin expression with a fracture of the third metacarpal (Mc-III) bone of Thoroughbred racehorses. Methods: A total of 30 Mc-III bones were obtained; ten bones were fractured during racing, ten were from the contralateral limb, and ten were from control horses. Each Mc-II...
The horse as a model of naturally occurring osteoarthritis. Osteoarthritis (OA) is an important cause of pain, disability and economic loss in humans, and is similarly important in the horse. Recent knowledge on post-traumatic OA has suggested opportunities for early intervention, but it is difficult to identify the appropriate time of these interventions. The horse provides two useful mechanisms to answer these questions: 1) extensive experience with clinical OA in horses; and 2) use of a consistently predictable model of OA that can help study early pathobiological events, define targets for therapeutic intervention and then test these putative thera...