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Home/Equine Research Bank/Bone Joint Res/The horse as a model of naturally occurring osteoarthritis.
Bone & joint research2012; 1(11); 297-309; doi: 10.1302/2046-3758.111.2000132

The horse as a model of naturally occurring osteoarthritis.

Abstract: Osteoarthritis (OA) is an important cause of pain, disability and economic loss in humans, and is similarly important in the horse. Recent knowledge on post-traumatic OA has suggested opportunities for early intervention, but it is difficult to identify the appropriate time of these interventions. The horse provides two useful mechanisms to answer these questions: 1) extensive experience with clinical OA in horses; and 2) use of a consistently predictable model of OA that can help study early pathobiological events, define targets for therapeutic intervention and then test these putative therapies. This paper summarises the syndromes of clinical OA in horses including pathogenesis, diagnosis and treatment, and details controlled studies of various treatment options using an equine model of clinical OA.
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Publication Date: 2012-11-01 PubMed ID: 23610661PubMed Central: PMC3626203DOI: 10.1302/2046-3758.111.2000132Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper discusses how horses serve as a practical model for studying osteoarthritis (OA), which is a significant cause of pain and disability in people. It provides a dual approach: analyzing clinical OA cases in horses and using a predictable OA model in horses to devise potential treatment solutions.

Understanding Osteoarthritis in Horses

Osteoarthritis (OA) is a condition that causes not only discomfort but also disability, both in humans and horses. The study pivots on the premise that understanding the progression, diagnosis, and treatment of OA in horses can provide crucial insights into addressing the condition in both species:

  • The paper examines the syndromes related to clinical osteoarthritis in horses. This includes the strategies for diagnosing the condition as well as the root causes or pathogenesis of the disease in equines.
  • The researchers also analyze the treatments currently deployed for managing OA in horses. This review provides a firm foundation for exploring potential interventions and curative strategies.

The Dual Approach to OA Research

The article discusses a dual approach in studying osteoarthritis in horses. This method helps in defining the right time for therapeutic intervention and provides a reliable platform for testing potential therapies:

  • One arm of the approach involves studying clinical OA in horses. This implies analyzing the practical experiences and real-world cases of equine OA. Leveraging these experiences enables the researchers to gain a more profound and practical understanding of the disease progression and treatment effects.
  • The second element utilizes a predictive, controlled model of OA in horses. This model allows the research team to scrutinize the early stages of the disease or “pathobiological” events, identifying areas where therapeutic intervention could potentially slow or halt the progression of OA.
  • The dual methodology not only studies the disease from a theoretical lens but also tests putative or proposed therapies in a controlled environment. Hence, it provides a well-rounded research base for the disorder.

Testing Potential Therapies

In this study, controlled experiments are carried out to test various treatment options for osteoarthritis. These tests are conducted using the horse model of clinical OA, offering a more nuanced understanding of therapeutic efficiency:

  • The consistent and predictable nature of the OA model used in horses helps in designing and assessing potential therapies, defining an avenue for early interventions.
  • By testing the likely therapies in real-world conditions, the researchers can conduct an extensive investigation of the possible treatments and identify the most effective ones.

Cite This Article

APA
McIlwraith CW, Frisbie DD, Kawcak CE. (2012). The horse as a model of naturally occurring osteoarthritis. Bone Joint Res, 1(11), 297-309. https://doi.org/10.1302/2046-3758.111.2000132

Publication

Bone & joint research
ISSN: 2046-3758
NlmUniqueID: 101586057
Country: England
Language: English
Volume: 1
Issue: 11
Pages: 297-309

Researcher Affiliations

McIlwraith, C W
  • Orthopaedic Research Center, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA.
Frisbie, D D
    Kawcak, C E

      Conflict of Interest Statement

      None declared

      References

      This article includes 124 references
      1. Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA, Buckwalter JA. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention.. J Orthop Res 2011 Jun;29(6):802-9.
        pmc: PMC3082940pubmed: 21520254doi: 10.1002/jor.21359google scholar: lookup
      2. Goldring MB, Goldring SR. Osteoarthritis.. J Cell Physiol 2007 Dec;213(3):626-34.
        pubmed: 17786965doi: 10.1002/jcp.21258google scholar: lookup
      3. Loeser RF. Age-related changes in the musculoskeletal system and the development of osteoarthritis.. Clin Geriatr Med 2010 Aug;26(3):371-86.
        pmc: PMC2920876pubmed: 20699160doi: 10.1016/j.cger.2010.03.002google scholar: lookup
      4. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, Jordan JM, Katz JN, Kremers HM, Wolfe F. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.. Arthritis Rheum 2008 Jan;58(1):26-35.
        pmc: PMC3266664pubmed: 18163497doi: 10.1002/art.23176google scholar: lookup
      5. Altman RD, Abramson S, Bruyere O, Clegg D, Herrero-Beaumont G, Maheu E, Moskowitz R, Pavelka K, Reginster JY. Commentary: osteoarthritis of the knee and glucosamine.. Osteoarthritis Cartilage 2006 Oct;14(10):963-6.
        pubmed: 16857394doi: 10.1016/j.joca.2006.06.010google scholar: lookup
      6. Saltzman CL, Zimmerman MB, O'Rourke M, Brown TD, Buckwalter JA, Johnston R. Impact of comorbidities on the measurement of health in patients with ankle osteoarthritis.. J Bone Joint Surg Am 2006 Nov;88(11):2366-72.
        pubmed: 17079392doi: 10.2106/JBJS.F.00295google scholar: lookup
      7. Dirschl DR, Marsh JL, Buckwalter JA, Gelberman R, Olson SA, Brown TD, Llinias A. Articular fractures.. J Am Acad Orthop Surg 2004 Nov-Dec;12(6):416-23.
        pubmed: 15615507doi: 10.5435/00124635-200411000-00006google scholar: lookup
      8. Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis.. Ann Intern Med 2000 Sep 5;133(5):321-8.
        pubmed: 10979876doi: 10.7326/0003-4819-133-5-200009050-00007google scholar: lookup
      9. Gillquist J, Messner K. Anterior cruciate ligament reconstruction and the long-term incidence of gonarthrosis.. Sports Med 1999 Mar;27(3):143-56.
        pubmed: 10222538doi: 10.2165/00007256-199927030-00001google scholar: lookup
      10. Roos H, Lauru00e9n M, Adalberth T, Roos EM, Jonsson K, Lohmander LS. Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls.. Arthritis Rheum 1998 Apr;41(4):687-93.
        pubmed: 9550478doi: 10.1002/1529-0131(199804)41:4<687::AID-ART16>3.0.CO;2-2google scholar: lookup
      11. Weigel DP, Marsh JL. High-energy fractures of the tibial plateau. Knee function after longer follow-up.. J Bone Joint Surg Am 2002 Sep;84(9):1541-51.
        pubmed: 12208910doi: 10.2106/00004623-200209000-00006google scholar: lookup
      12. McIlwraith CW. Frank Milne Lecture: From arthroscopy to gene therapy: 30 years of looking in joints. Am Assoc Equine Pract 2005;51:65u2013113
      13. McIlwraith CW, Frisbie DD, Kawcak CE, Fuller CJ, Hurtig M, Cruz A. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse.. Osteoarthritis Cartilage 2010 Oct;18 Suppl 3:S93-105.
        pubmed: 20864027doi: 10.1016/j.joca.2010.05.031google scholar: lookup
      14. McIlwraith CW. General pathobiology of the joint and response to injury. In: McIlwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders Company, 1996:40u201370.
      15. Goodrich LR, Nixon AJ. Medical treatment of osteoarthritis in the horse - a review.. Vet J 2006 Jan;171(1):51-69.
        pubmed: 16427582doi: 10.1016/j.tvjl.2004.07.008google scholar: lookup
      16. Caron JP. Osteoarthritis. In: Ross MW, Dyson SJ, eds. Diagnosis and management of lameness in the horse. 2nd edition. St Louis: Elsevier Saunders, 2011:655u2013668.
      17. United States Department of Agriculture. Lameness and laminitis in U.S. Horses. National Animal Health Monitoring System, 2000. http://www.aphis.usda.gov/animal_health/nahms/equine/downloads/equine98/Equine98_dr_Lameness.pdf (date last accessed 20 September 2012).
      18. Caron JP, Genovese RL. Principles and practices of joint disease treatment. In: Ross MW, Dyson SJ, eds. Diagnosis and management of lameness in the horse. Philadelphia: Elsevier, 2003:746u2013764.
      19. Koch TG, Betts DH. Stem cell therapy for joint problems using the horse as a clinically relevant animal model.. Expert Opin Biol Ther 2007 Nov;7(11):1621-6.
        pubmed: 17961087doi: 10.1517/14712598.7.11.1621google scholar: lookup
      20. Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB. Osteoarthritis cartilage histopathology: grading and staging.. Osteoarthritis Cartilage 2006 Jan;14(1):13-29.
        pubmed: 16242352doi: 10.1016/j.joca.2005.07.014google scholar: lookup
      21. Dray A, Read SJ. Arthritis and pain. Future targets to control osteoarthritis pain.. Arthritis Res Ther 2007;9(3):212.
        pmc: PMC2206352pubmed: 17561993doi: 10.1186/ar2178google scholar: lookup
      22. Neundorf RH, Lowerison MB, Cruz AM, Thomason JJ, McEwen BJ, Hurtig MB. Determination of the prevalence and severity of metacarpophalangeal joint osteoarthritis in Thoroughbred racehorses via quantitative macroscopic evaluation.. Am J Vet Res 2010 Nov;71(11):1284-93.
        pubmed: 21034319doi: 10.2460/ajvr.71.11.1284google scholar: lookup
      23. Norrdin RW, Stover SM. Subchondral bone failure in overload arthrosis: a scanning electron microscopic study in horses.. J Musculoskelet Neuronal Interact 2006 Jul-Sep;6(3):251-7.
        pubmed: 17142946
      24. Drum MG, Kawcak CE, Norrdin RW, Park RD, McIlwraith CW, Les CM. Comparison of gross and histopathologic findings with quantitative computed tomographic bone density in the distal third metacarpal bone of racehorses.. Vet Radiol Ultrasound 2007 Nov-Dec;48(6):518-27.
        pubmed: 18018722doi: 10.1111/j.1740-8261.2007.00289.xgoogle scholar: lookup
      25. Callender GR, Kelser RA. Degenerative arthritis: A comparison of the pathological changes in man and equines.. Am J Pathol 1938 May;14(3):253-272.9.
        pmc: PMC1964953pubmed: 19970389
      26. Mackay-Smith MP. Pathogenesis and pathology of equine osteoarthritis. J Am Med Vet Assoc 1962;141:1246u20131252
      27. Raker CW, Baker RH, Wheat JD. Pathophysiology of equine degenerative joint disease and lameness. Am Assoc Equine Pract 1966;12:229u2013241
      28. Rooney JR. Biomechanics of lameness in horses. Baltimore: Williams and Wilkins, 1969.
      29. Nilsson G, Olsson SE. Radiologic and patho-anatomic changes in the distal joints and the phalanges of the standardbred horse.. Acta Vet Scand Suppl 1973;44(0):1-57.
        pubmed: 4529375
      30. Brandt KD, Dieppe P, Radin EL. Etiopathogenesis of osteoarthritis.. Rheum Dis Clin North Am 2008 Aug;34(3):531-59.
        pubmed: 18687271doi: 10.1016/j.rdc.2008.05.011google scholar: lookup
      31. McIlwraith CW. Current concepts in equine degenerative joint disease.. J Am Vet Med Assoc 1982 Feb 1;180(3):239-50.
        pubmed: 7035425
      32. Riggs CM, Whitehouse GH, Boyde A. Pathology of the distal condyles of the third metacarpal and third metatarsal bones of the horse.. Equine Vet J 1999 Mar;31(2):140-8.
        pubmed: 10213426doi: 10.1111/j.2042-3306.1999.tb03807.xgoogle scholar: lookup
      33. Kawcak CE, McIlwraith CW, Norrdin RW, Park RD, James SP. The role of subchondral bone in joint disease: a review.. Equine Vet J 2001 Mar;33(2):120-6.
        pubmed: 11266060doi: 10.1111/j.2042-3306.2001.tb00589.xgoogle scholar: lookup
      34. McIlwraith CW, Yovich JV, Martin GS. Arthroscopic surgery for the treatment of osteochondral chip fractures in the equine carpus.. J Am Vet Med Assoc 1987 Sep 1;191(5):531-40.
        pubmed: 3667408
      35. Kawcak CE, McIlwraith CW. Proximodorsal first phalanx osteochondral chip fragmentation in 336 horses.. Equine Vet J 1994 Sep;26(5):392-6.
        pubmed: 7988543doi: 10.1111/j.2042-3306.1994.tb04409.xgoogle scholar: lookup
      36. Frisbie DD, Ray CS, Ionescu M, Poole AR, Chapman PL, McIlwraith CW. Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses.. Am J Vet Res 1999 Mar;60(3):306-9.
        pubmed: 10188811
      37. Fuller CJ, Barr AR, Sharif M, Dieppe PA. Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage.. Osteoarthritis Cartilage 2001 Jan;9(1):49-55.
        pubmed: 11178947doi: 10.1053/joca.2000.0349google scholar: lookup
      38. McIlwraith CW, Vachon A. Review of pathogenesis and treatment of degenerative joint disease.. Equine Vet J Suppl 1988 Sep;(6):3-11.
        pubmed: 9079056doi: 10.1111/j.2042-3306.1988.tb04641.xgoogle scholar: lookup
      39. Buckwalter JA. Articular cartilage injuries.. Clin Orthop Relat Res 2002 Sep;(402):21-37.
        pubmed: 12218470doi: 10.1097/00003086-200209000-00004google scholar: lookup
      40. Buckwalter JA, Brown TD. Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis.. Clin Orthop Relat Res 2004 Jun;(423):7-16.
        pubmed: 15232420
      41. Olson SA, Guilak F. From articular fracture to posttraumatic arthritis: a black box that needs to be opened.. J Orthop Trauma 2006 Nov-Dec;20(10):661-2.
        pubmed: 17106374doi: 10.1097/01.bot.0000245683.89152.55google scholar: lookup
      42. McIlwraith CW, Van Sickle DC. Experimentally induced arthritis of the equine carpus: histologic and histochemical changes in the articular cartilage.. Am J Vet Res 1981 Feb;42(2):209-17.
        pubmed: 7258770
      43. Balkman CE, Nixon AJ. Molecular cloning and cartilage gene expression of equine stromelysin 1 (matrix metalloproteinase 3).. Am J Vet Res 1998 Jan;59(1):30-6.
        pubmed: 9442239
      44. Clegg PD, Burke RM, Coughlan AR, Riggs CM, Carter SD. Characterisation of equine matrix metalloproteinase 2 and 9; and identification of the cellular sources of these enzymes in joints.. Equine Vet J 1997 Sep;29(5):335-42.
        pubmed: 9306058doi: 10.1111/j.2042-3306.1997.tb03136.xgoogle scholar: lookup
      45. Clegg PD, Coughlan AR, Riggs CM, Carter SD. Matrix metalloproteinases 2 and 9 in equine synovial fluids.. Equine Vet J 1997 Sep;29(5):343-8.
        pubmed: 9306059doi: 10.1111/j.2042-3306.1997.tb03137.xgoogle scholar: lookup
      46. Trumble TN, Trotter GW, Oxford JR, McIlwraith CW, Cammarata S, Goodnight JL, Billinghurst RC, Frisbie DD. Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses.. Am J Vet Res 2001 Sep;62(9):1467-77.
        pubmed: 11560279doi: 10.2460/ajvr.2001.62.1467google scholar: lookup
      47. Kawcak CE, Frisbie DD, Trotter GW, McIlwraith CW, Gillette SM, Powers BE, Walton RM. Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation.. Am J Vet Res 1997 Oct;58(10):1132-40.
        pubmed: 9328667
      48. Dimock AN, Siciliano PD, McIlwraith CW. Evidence supporting an increased presence of reactive oxygen species in the diseased equine joint.. Equine Vet J 2000 Sep;32(5):439-43.
        pubmed: 11037267doi: 10.2746/042516400777591129google scholar: lookup
      49. Takafuji VA, McIlwraith CW, Howard RD. Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants.. Am J Vet Res 2002 Apr;63(4):551-8.
        pubmed: 11939318doi: 10.2460/ajvr.2002.63.551google scholar: lookup
      50. Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene.. Gene Ther 2002 Jan;9(1):12-20.
        pubmed: 11850718doi: 10.1038/sj.gt.3301608google scholar: lookup
      51. Kamm JL, Nixon AJ, Witte TH. Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.. Equine Vet J 2010 Nov;42(8):693-9.
        pmc: PMC4183755pubmed: 21039798doi: 10.1111/j.2042-3306.2010.00140.xgoogle scholar: lookup
      52. Frisbie DD, McIlwraith CW. Gene therapy: future therapies in osteoarthritis.. Vet Clin North Am Equine Pract 2001 Aug;17(2):233-43, vi.
        pubmed: 15658173doi: 10.1016/s0749-0739(17)30059-7google scholar: lookup
      53. Berenbaum F. The quest for the Holy Grail: a disease-modifying osteoarthritis drug.. Arthritis Res Ther 2007;9(6):111.
        pmc: PMC2246245pubmed: 18096086doi: 10.1186/ar2335google scholar: lookup
      54. Toncheva A, Remichkova M, Ikonomova K, Dimitrova P, Ivanovska N. Inflammatory response in patients with active and inactive osteoarthritis.. Rheumatol Int 2009 Aug;29(10):1197-203.
        pubmed: 19184030doi: 10.1007/s00296-009-0864-0google scholar: lookup
      55. Wassilew GI, Lehnigk U, Duda GN, Taylor WR, Matziolis G, Dynybil C. The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders.. Arthroscopy 2010 Aug;26(8):1096-104.
        pubmed: 20678708doi: 10.1016/j.arthro.2009.12.018google scholar: lookup
      56. Goekoop RJ, Kloppenburg M, Kroon HM, Fru00f6lich M, Huizinga TW, Westendorp RG, Gussekloo J. Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age.. Osteoarthritis Cartilage 2010 Jul;18(7):942-7.
        pubmed: 20417290doi: 10.1016/j.joca.2010.03.016google scholar: lookup
      57. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis.. Nat Rev Rheumatol 2010 Nov;6(11):625-35.
        pubmed: 20924410doi: 10.1038/nrrheum.2010.159google scholar: lookup
      58. Mueller MB, Tuan RS. Anabolic/Catabolic balance in pathogenesis of osteoarthritis: identifying molecular targets.. PM R 2011 Jun;3(6 Suppl 1):S3-11.
        pubmed: 21703577doi: 10.1016/j.pmrj.2011.05.009google scholar: lookup
      59. Morisset S, Frisbie DD, Robbins PD, Nixon AJ, McIlwraith CW. IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects.. Clin Orthop Relat Res 2007 Sep;462:221-8.
        pubmed: 17534189doi: 10.1097/BLO.0b013e3180dca05fgoogle scholar: lookup
      60. Varich L, Pathria M, Resnick D, Hodler J, Bruser D, Bosch E, Trudell D, Tyson R. Patterns of central acetabular osteophytosis in osteoarthritis of the hip.. Invest Radiol 1993 Dec;28(12):1120-7.
        pubmed: 8307715doi: 10.1097/00004424-199312000-00007google scholar: lookup
      61. McCauley TR. MR imaging of chondral and osteochondral injuries of the knee.. Radiol Clin North Am 2002 Sep;40(5):1095-107.
        pubmed: 12462470doi: 10.1016/s0033-8389(02)00034-9google scholar: lookup
      62. Olive J, D'Anjou MA, Girard C, Laverty S, Theoret CL. Imaging and histological features of central subchondral osteophytes in racehorses with metacarpophalangeal joint osteoarthritis.. Equine Vet J 2009 Dec;41(9):859-64.
        pubmed: 20383982doi: 10.2746/042516409x448481google scholar: lookup
      63. Steinmeyer J, Konttinen YT. Oral treatment options for degenerative joint disease--presence and future.. Adv Drug Deliv Rev 2006 May 20;58(2):168-211.
        pubmed: 16616797doi: 10.1016/j.addr.2006.01.007google scholar: lookup
      64. Zhang W, Doherty M, Arden N, Bannwarth B, Bijlsma J, Gunther KP, Hauselmann HJ, Herrero-Beaumont G, Jordan K, Kaklamanis P, Leeb B, Lequesne M, Lohmander S, Mazieres B, Martin-Mola E, Pavelka K, Pendleton A, Punzi L, Swoboda B, Varatojo R, Verbruggen G, Zimmermann-Gorska I, Dougados M. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).. Ann Rheum Dis 2005 May;64(5):669-81.
        pmc: PMC1755499pubmed: 15471891doi: 10.1136/ard.2004.028886google scholar: lookup
      65. Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, Gunther K, Hauselmann H, Herrero-Beaumont G, Kaklamanis P, Lohmander S, Leeb B, Lequesne M, Mazieres B, Martin-Mola E, Pavelka K, Pendleton A, Punzi L, Serni U, Swoboda B, Verbruggen G, Zimmerman-Gorska I, Dougados M. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT).. Ann Rheum Dis 2003 Dec;62(12):1145-55.
        pmc: PMC1754382pubmed: 14644851doi: 10.1136/ard.2003.011742google scholar: lookup
      66. . Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines.. Arthritis Rheum 2000 Sep;43(9):1905-15.
        pubmed: 11014340doi: 10.1002/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-Pgoogle scholar: lookup
      67. Chard JA, Tallon D, Dieppe PA. Epidemiology of research into interventions for the treatment of osteoarthritis of the knee joint.. Ann Rheum Dis 2000 Jun;59(6):414-8.
        pmc: PMC1753176pubmed: 10834855doi: 10.1136/ard.59.6.414google scholar: lookup
      68. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.. JAMA 2000 Mar 15;283(11):1469-75.
        pubmed: 10732937doi: 10.1001/jama.283.11.1469google scholar: lookup
      69. Qvist P, Bay-Jensen AC, Christiansen C, Dam EB, Pastoureau P, Karsdal MA. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?. Pharmacol Res 2008 Jul;58(1):1-7.
        pubmed: 18590824doi: 10.1016/j.phrs.2008.06.001google scholar: lookup
      70. Bingham CO 3rd, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study.. Arthritis Rheum 2006 Nov;54(11):3494-507.
        pubmed: 17075851doi: 10.1002/art.22160google scholar: lookup
      71. Gaustad G, Larsen S. Comparison of polysulphated glycosaminoglycan and sodium hyaluronate with placebo in treatment of traumatic arthritis in horses.. Equine Vet J 1995 Sep;27(5):356-62.
        pubmed: 8654350doi: 10.1111/j.2042-3306.1995.tb04070.xgoogle scholar: lookup
      72. Sabatu00e9 D, Homedes J, Salichs M, Sust M, Monreal L. Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses.. Equine Vet J 2009 Sep;41(7):700-5.
        pubmed: 19927590doi: 10.2746/042516409x464807google scholar: lookup
      73. Gough MR, Thibaud D, Smith RK. Tiludronate infusion in the treatment of bone spavin: a double blind placebo-controlled trial.. Equine Vet J 2010 Jul;42(5):381-7.
        pubmed: 20636772doi: 10.1111/j.2042-3306.2010.00120.xgoogle scholar: lookup
      74. Cayzer J, Hedderley D, Gray S. A randomised, double-blinded, placebo-controlled study on the efficacy of a unique extract of green-lipped mussel (Perna canaliculus) in horses with chronic fetlock lameness attributed to osteoarthritis.. Equine Vet J 2012 Jul;44(4):393-8.
        pubmed: 21883418doi: 10.1111/j.2042-3306.2011.00455.xgoogle scholar: lookup
      75. Clegg PD. Investigating the efficacy of articular medications in the horse: the science behind clinical practices.. Equine Vet J 2010 Sep;42(6):484-6.
        pubmed: 20716186doi: 10.1111/j.2042-3306.2010.00210.xgoogle scholar: lookup
      76. Frisbie DD, Al-Sobayil F, Billinghurst RC, Kawcak CE, McIlwraith CW. Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses.. Osteoarthritis Cartilage 2008 Oct;16(10):1196-204.
        pubmed: 18442931doi: 10.1016/j.joca.2008.03.008google scholar: lookup
      77. Kawcak CE, Frisbie DD, Werpy NM, Park RD, McIlwraith CW. Effects of exercise vs experimental osteoarthritis on imaging outcomes.. Osteoarthritis Cartilage 2008 Dec;16(12):1519-25.
        pubmed: 18504148doi: 10.1016/j.joca.2008.04.015google scholar: lookup
      78. Le Graverand-Gastineau MP. Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets.. Curr Drug Targets 2010 May;11(5):528-35.
        pubmed: 20199396doi: 10.2174/138945010791011893google scholar: lookup
      79. Aigner T, Cook JL, Gerwin N, Glasson SS, Laverty S, Little CB, McIlwraith W, Kraus VB. Histopathology atlas of animal model systems - overview of guiding principles.. Osteoarthritis Cartilage 2010 Oct;18 Suppl 3:S2-6.
        pubmed: 20864020doi: 10.1016/j.joca.2010.07.013google scholar: lookup
      80. McIlwraith CW, Fessler JF, Blevins WE, Page EH, Rebar AH, Van Sickle DC, Coppoc GL. Experimentally induced arthritis of the equine carpus: clinical determinations.. Am J Vet Res 1979 Jan;40(1):11-20.
        pubmed: 453671
      81. Gustafson SB, Trotter GW, Norrdin RW, Wrigley RH, Lamar C. Evaluation of intra-articularly administered sodium monoiodoacetate-induced chemical injury to articular cartilage of horses.. Am J Vet Res 1992 Jul;53(7):1193-202.
        pubmed: 1497191
      82. Yovich JV, Trotter GW, McIlwraith CW, Norrdin RW. Effects of polysulfated glycosaminoglycan on chemical and physical defects in equine articular cartilage.. Am J Vet Res 1987 Sep;48(9):1407-14.
        pubmed: 3662210
      83. Trotter GW, Yovich JV, McIlwraith CW, Norrdin RW. Effects of intramuscular polysulfated glycosaminoglycan on chemical and physical defects in equine articular cartilage.. Can J Vet Res 1989 Apr;53(2):224-30.
        pmc: PMC1255551pubmed: 2469533
      84. Peloso JG, Stick JA, Caron JP, Peloso PM, Soutas-Little RW. Effects of hylan on amphotericin-induced carpal lameness in equids.. Am J Vet Res 1993 Sep;54(9):1527-34.
        pubmed: 8239145
      85. Firth EC, Wensing T, Seuren F. An induced synovitis disease model in ponies.. Cornell Vet 1987 Apr;77(2):107-18.
        pubmed: 3552439
      86. Todhunter PG, Kincaid SA, Todhunter RJ, Kammermann JR, Johnstone B, Baird AN, Hanson RR, Wright JM, Lin HC, Purohit RC. Immunohistochemical analysis of an equine model of synovitis-induced arthritis.. Am J Vet Res 1996 Jul;57(7):1080-93.
        pubmed: 8807026
      87. Palmer JL, Bertone AL, Malemud CJ, Mansour J. Biochemical and biomechanical alterations in equine articular cartilage following an experimentally-induced synovitis.. Osteoarthritis Cartilage 1996 Jun;4(2):127-37.
        pubmed: 8806114doi: 10.1016/s1063-4584(05)80321-8google scholar: lookup
      88. Hardy J, Bertone AL, Weisbrode SE, Muir WW, O'Dorisio TM, Masty J. Cell trafficking, mediator release, and articular metabolism in acute inflammation of innervated or denervated isolated equine joints.. Am J Vet Res 1998 Jan;59(1):88-100.
        pubmed: 9442251
      89. Cornelissen BP, Rijkenhuizen AB, van den Hoogen BM, Rutten VP, Barneveld A. Experimental model of synovitis/capsulitis in the equine metacarpophalangeal joint.. Am J Vet Res 1998 Aug;59(8):978-85.
        pubmed: 9706201
      90. Owens JG, Kamerling SG, Stanton SR, Keowen ML, Prescott-Mathews JS. Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses.. Am J Vet Res 1996 Jun;57(6):866-74.
        pubmed: 8725815
      91. Auer JA, Fackelman GE, Gingerich DA, Fetter AW. Effect of hyaluronic acid in naturally occurring and experimentally induced osteoarthritis.. Am J Vet Res 1980 Apr;41(4):568-74.
        pubmed: 7406275
      92. Simmons EJ, Bertone AL, Weisbrode SE. Instability-induced osteoarthritis in the metacarpophalangeal joint of horses.. Am J Vet Res 1999 Jan;60(1):7-13.
        pubmed: 9918142
      93. Frisbie DD, Kawcak CE, Trotter GW, Powers BE, Walton RM, McIlwraith CW. Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model.. Equine Vet J 1997 Sep;29(5):349-59.
        pubmed: 9306060doi: 10.1111/j.2042-3306.1997.tb03138.xgoogle scholar: lookup
      94. Kawcak CE, Norrdin RW, Frisbie DD, Trotter GW, Mcilwraith CW. Effects of osteochondral fragmentation and intra-articular triamcinolone acetonide treatment on subchondral bone in the equine carpus.. Equine Vet J 1998 Jan;30(1):66-71.
        pubmed: 9458401doi: 10.1111/j.2042-3306.1998.tb04090.xgoogle scholar: lookup
      95. Frisbie DD, Kawcak CE, Baxter GM, Trotter GW, Powers BE, Lassen ED, McIlwraith CW. Effects of 6alpha-methylprednisolone acetate on an equine osteochondral fragment exercise model.. Am J Vet Res 1998 Dec;59(12):1619-28.
        pubmed: 9858417
      96. Frisbie DD, Kawcak CE, Werpy NM, Park RD, McIlwraith CW. Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis.. Am J Vet Res 2007 Mar;68(3):290-6.
        pubmed: 17331019doi: 10.2460/ajvr.68.3.290google scholar: lookup
      97. Kawcak CE, Frisbie DD, McIlwraith CW, Werpy NM, Park RD. Evaluation of avocado and soybean unsaponifiable extracts for treatment of horses with experimentally induced osteoarthritis.. Am J Vet Res 2007 Jun;68(6):598-604.
        pubmed: 17542691doi: 10.2460/ajvr.68.6.598google scholar: lookup
      98. Bolam CJ, Hurtig MB, Cruz A, McEwen BJ. Characterization of experimentally induced post-traumatic osteoarthritis in the medial femorotibial joint of horses.. Am J Vet Res 2006 Mar;67(3):433-47.
        pubmed: 16506905doi: 10.2460/ajvr.67.3.433google scholar: lookup
      99. Frisbie DD, Cross MW, McIlwraith CW. A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee.. Vet Comp Orthop Traumatol 2006;19(3):142-6.
        pubmed: 16971996
      100. Richardson DW, Clark CC. Effects of short-term cast immobilization on equine articular cartilage.. Am J Vet Res 1993 Mar;54(3):449-53.
        pubmed: 8498752
      101. Van Harreveld PD, Lillich JD, Kawcak CE, Gaughan EM, Mclaughlin RM, Debowes RM. Clinical evaluation of the effects of immobilization followed by remobilization and exercise on the metacarpophalangeal joint in horses.. Am J Vet Res 2002 Feb;63(2):282-8.
        pubmed: 11843131doi: 10.2460/ajvr.2002.63.282google scholar: lookup
      102. van Harreveld PD, Lillich JD, Kawcak CE, Turner AS, Norrdin RW. Effects of immobilization followed by remobilization on mineral density, histomorphometric features, and formation of the bones of the metacarpophalangeal joint in horses.. Am J Vet Res 2002 Feb;63(2):276-81.
        pubmed: 11843130doi: 10.2460/ajvr.2002.63.276google scholar: lookup
      103. Foland JW, McIlwraith CW, Trotter GW, Powers BE, Lamar CH. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments.. Vet Surg 1994 Sep-Oct;23(5):369-76.
        pubmed: 7839595doi: 10.1111/j.1532-950x.1994.tb00497.xgoogle scholar: lookup
      104. No authors listed. Definition and classification of lameness. In: Guide for veterinary service and judging of equestrian events. Lexington: American Association of Equine Practitioners, 1991:19.
      105. Peterson B, Szabo RM. Carpal osteoarthrosis.. Hand Clin 2006 Nov;22(4):517-28; abstract vii.
        pubmed: 17097471doi: 10.1016/j.hcl.2006.07.001google scholar: lookup
      106. McIlwraith CW. The use of intra-articular corticosteroids in the horse: what is known on a scientific basis?. Equine Vet J 2010 Sep;42(6):563-71.
        pubmed: 20716199doi: 10.1111/j.2042-3306.2010.00095.xgoogle scholar: lookup
      107. Frisbie DD, Kawcak CE, McIlwraith CW, Werpy NM. Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis.. Am J Vet Res 2009 Feb;70(2):203-9.
        pubmed: 19231952doi: 10.2460/ajvr.70.2.203google scholar: lookup
      108. Goodrich LR, Choi VW, Carbone BA, McIlwraith CW, Samulski RJ. Ex vivo serotype-specific transduction of equine joint tissue by self-complementary adeno-associated viral vectors.. Hum Gene Ther 2009 Dec;20(12):1697-702.
        pmc: PMC2861962pubmed: 19642864doi: 10.1089/hum.2009.030google scholar: lookup
      109. Meijer H, Reinecke J, Becker C, Tholen G, Wehling P. The production of anti-inflammatory cytokines in whole blood by physico-chemical induction.. Inflamm Res 2003 Oct;52(10):404-7.
        pubmed: 14520515doi: 10.1007/s00011-003-1197-1google scholar: lookup
      110. Brown C, Toth A, Magnussen R. Clinical benefits of intra-articular anakinra for persistent knee effusion.. J Knee Surg 2011 Mar;24(1):61-5.
        pubmed: 21618940doi: 10.1055/s-0031-1275398google scholar: lookup
      111. Frisbie DD, Kisiday JD, Kawcak CE, Werpy NM, McIlwraith CW. Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis.. J Orthop Res 2009 Dec;27(12):1675-80.
        pubmed: 19544397doi: 10.1002/jor.20933google scholar: lookup
      112. McIlwraith CW, Frisbie DD, Kawcak CE. Evaluation of intramuscularly administered sodium pentosan polysulfate for treatment of experimentally induced osteoarthritis in horses.. Am J Vet Res 2012 May;73(5):628-33.
        pubmed: 22533393doi: 10.2460/ajvr.73.5.628google scholar: lookup
      113. Frisbie DD, McIlwraith CW, Kawcak CE, Werpy NM, Pearce GL. Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis.. Am J Vet Res 2009 Feb;70(2):210-5.
        pubmed: 19231953doi: 10.2460/ajvr.70.2.210google scholar: lookup
      114. Frisbie DD, Kawcak CE, McIlwraith CW. Evaluation of the effect of extracorporeal shock wave treatment on experimentally induced osteoarthritis in middle carpal joints of horses.. Am J Vet Res 2009 Apr;70(4):449-54.
        pubmed: 19335099doi: 10.2460/ajvr.70.4.449google scholar: lookup
      115. Kawcak CE, Frisbie DD, McIlwraith CW. Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis.. Am J Vet Res 2011 Jun;72(6):772-9.
        pubmed: 21627523doi: 10.2460/ajvr.72.6.772google scholar: lookup
      116. Cicuttini F, Ding C, Wluka A, Davis S, Ebeling PR, Jones G. Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study.. Arthritis Rheum 2005 Jul;52(7):2033-9.
        pubmed: 15986359doi: 10.1002/art.21148google scholar: lookup
      117. Davies-Tuck ML, Wluka AE, Wang Y, Teichtahl AJ, Jones G, Ding C, Cicuttini FM. The natural history of cartilage defects in people with knee osteoarthritis.. Osteoarthritis Cartilage 2008 Mar;16(3):337-42.
        pubmed: 17698376doi: 10.1016/j.joca.2007.07.005google scholar: lookup
      118. McIlwraith CW, Fortier LA, Frisbie DD, Nixon AJ. Equine Models of Articular Cartilage Repair.. Cartilage 2011 Oct;2(4):317-26.
        pmc: PMC4297134pubmed: 26069590doi: 10.1177/1947603511406531google scholar: lookup
      119. Frisbie DD, Trotter GW, Powers BE, Rodkey WG, Steadman JR, Howard RD, Park RD, McIlwraith CW. Arthroscopic subchondral bone plate microfracture technique augments healing of large chondral defects in the radial carpal bone and medial femoral condyle of horses.. Vet Surg 1999 Jul-Aug;28(4):242-55.
        pubmed: 10424704doi: 10.1053/jvet.1999.0242google scholar: lookup
      120. Frisbie DD, Oxford JT, Southwood L, Trotter GW, Rodkey WG, Steadman JR, Goodnight JL, McIlwraith CW. Early events in cartilage repair after subchondral bone microfracture.. Clin Orthop Relat Res 2003 Feb;(407):215-27.
        pubmed: 12567150doi: 10.1097/00003086-200302000-00031google scholar: lookup
      121. Frisbie DD, Morisset S, Ho CP, Rodkey WG, Steadman JR, McIlwraith CW. Effects of calcified cartilage on healing of chondral defects treated with microfracture in horses.. Am J Sports Med 2006 Nov;34(11):1824-31.
        pubmed: 16832126doi: 10.1177/0363546506289882google scholar: lookup
      122. McIlwraith CW, Frisbie DD, Rodkey WG, Kisiday JD, Werpy NM, Kawcak CE, Steadman JR. Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects.. Arthroscopy 2011 Nov;27(11):1552-61.
        pubmed: 21862278doi: 10.1016/j.arthro.2011.06.002google scholar: lookup
      123. Frisbie DD, Bowman SM, Colhoun HA, DiCarlo EF, Kawcak CE, McIlwraith CW. Evaluation of autologous chondrocyte transplantation via a collagen membrane in equine articular defects: results at 12 and 18 months.. Osteoarthritis Cartilage 2008 Jun;16(6):667-79.
        pubmed: 18042409doi: 10.1016/j.joca.2007.09.013google scholar: lookup
      124. Frisbie DD, Lu Y, Kawcak CE, DiCarlo EF, Binette F, McIlwraith CW. In vivo evaluation of autologous cartilage fragment-loaded scaffolds implanted into equine articular defects and compared with autologous chondrocyte implantation.. Am J Sports Med 2009 Nov;37 Suppl 1:71S-80S.
        pubmed: 19934439doi: 10.1177/0363546509348478google scholar: lookup

      Citations

      This article has been cited 96 times.
      1. Thampi P, Seabaugh KA, Pezzanite LM, Chu CR, Phillips JN, Grieger JC, McIlwraith CW, Samulski RJ, Goodrich LR. A pilot study to determine the optimal dose of scAAVIL-1ra in a large animal model of post-traumatic osteoarthritis.. Gene Ther 2023 Sep 11;.
        doi: 10.1038/s41434-023-00420-2pubmed: 37696981google scholar: lookup
      2. Mayet A, Zablotski Y, Roth SP, Brehm W, Troillet A. Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis.. Front Vet Sci 2023;10:1125695.
        doi: 10.3389/fvets.2023.1125695pubmed: 36908512google scholar: lookup
      3. Jammes M, Contentin R, Cassu00e9 F, Galu00e9ra P. Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies.. Front Vet Sci 2023;10:1115774.
        doi: 10.3389/fvets.2023.1115774pubmed: 36846261google scholar: lookup
      4. Szponder T, Latalski M, Danielewicz A, Krau0107 K, Kozera A, Drzewiecka B, Nguyen Ngoc D, Dobko D, Wessely-Szponder J. Osteoarthritis: Pathogenesis, Animal Models, and New Regenerative Therapies.. J Clin Med 2022 Dec 20;12(1).
        doi: 10.3390/jcm12010005pubmed: 36614806google scholar: lookup
      5. Chawla S, Mainardi A, Majumder N, Du00f6nges L, Kumar B, Occhetta P, Martin I, Egloff C, Ghosh S, Bandyopadhyay A, Barbero A. Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies.. Cells 2022 Dec 13;11(24).
        doi: 10.3390/cells11244034pubmed: 36552796google scholar: lookup
      6. Clarke EJ, Johnson E, Caamau00f1o Gutierrez E, Andersen C, Berg LC, Jenkins RE, Lindegaard C, Uvebrant K, Lundgren-u00c5kerlund E, Turlo A, James V, Jacobsen S, Peffers MJ. Temporal extracellular vesicle protein changes following intraarticular treatment with integrin u03b110u03b21-selected mesenchymal stem cells in equine osteoarthritis.. Front Vet Sci 2022;9:1057667.
        doi: 10.3389/fvets.2022.1057667pubmed: 36504839google scholar: lookup
      7. Bowlby CM, Purmessur D, Durgam SS. Equine peripheral blood CD14(+) monocyte-derived macrophage in-vitro characteristics after GM-CSF pretreatment and LPS+IFN-u03b3 or IL-4+IL-10 differentiation.. Vet Immunol Immunopathol 2023 Jan;255:110534.
        doi: 10.1016/j.vetimm.2022.110534pubmed: 36502640google scholar: lookup
      8. Pezzanite LM, Chow L, Phillips J, Griffenhagen GM, Moore AR, Schaer TP, Engiles JB, Werpy N, Gilbertie J, Schnabel LV, Antczak D, Miller D, Dow S, Goodrich LR. TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant Staphylococcal septic arthritis in an equine model.. Ann Transl Med 2022 Nov;10(21):1157.
        doi: 10.21037/atm-22-1746pubmed: 36467344google scholar: lookup
      9. Pezzanite LM, Chow L, Strumpf A, Johnson V, Dow SW. Immune Activated Cellular Therapy for Drug Resistant Infections: Rationale, Mechanisms, and Implications for Veterinary Medicine.. Vet Sci 2022 Nov 4;9(11).
        doi: 10.3390/vetsci9110610pubmed: 36356087google scholar: lookup
      10. Pan S, Wang L, Wu B, Xing H. Effect and Mechanism of siRNAs Targeting IL-1u03b2/TNF-u03b1 Combined with BMSCs Transplantation in Ameliorating Rheumatoid Arthritis in Rats.. Vet Sci 2022 Sep 28;9(10).
        doi: 10.3390/vetsci9100531pubmed: 36288143google scholar: lookup
      11. Mustonen AM, Lehmonen N, Oikari S, Capra J, Raekallio M, Mykku00e4nen A, Paakkonen T, Rilla K, Niemelu00e4 T, Nieminen P. Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis.. Sci Rep 2022 Oct 20;12(1):17550.
        doi: 10.1038/s41598-022-21398-8pubmed: 36266410google scholar: lookup
      12. Thampi P, Samulski RJ, Grieger JC, Phillips JN, McIlwraith CW, Goodrich LR. Gene therapy approaches for equine osteoarthritis.. Front Vet Sci 2022;9:962898.
        doi: 10.3389/fvets.2022.962898pubmed: 36246316google scholar: lookup
      13. Moccia V, Sammarco A, Cavicchioli L, Castagnaro M, Bongiovanni L, Zappulli V. Extracellular Vesicles in Veterinary Medicine.. Animals (Basel) 2022 Oct 10;12(19).
        doi: 10.3390/ani12192716pubmed: 36230457google scholar: lookup
      14. Liu TP, Ha P, Xiao CY, Kim SY, Jensen AR, Easley J, Yao Q, Zhang X. Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models.. Front Cell Dev Biol 2022;10:982199.
        doi: 10.3389/fcell.2022.982199pubmed: 36147737google scholar: lookup
      15. Banstola A, Reynolds JNJ. The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders.. Biology (Basel) 2022 Aug 23;11(9).
        doi: 10.3390/biology11091251pubmed: 36138730google scholar: lookup
      16. Clarke EJ, Lima C, Anderson JR, Castanheira C, Beckett A, James V, Hyett J, Goodacre R, Peffers MJ. Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls.. Anal Methods 2022 Sep 29;14(37):3661-3670.
        doi: 10.1039/d2ay00779gpubmed: 36066093google scholar: lookup
      17. Cullier A, Cassu00e9 F, Manivong S, Contentin R, Legendre F, Garcia Ac A, Sirois P, Roullin G, Banquy X, Moldovan F, Bertoni L, Audigiu00e9 F, Galu00e9ra P, Demoor M. Functionalized Nanogels with Endothelin-1 and Bradykinin Receptor Antagonist Peptides Decrease Inflammatory and Cartilage Degradation Markers of Osteoarthritis in a Horse Organoid Model of Cartilage.. Int J Mol Sci 2022 Aug 11;23(16).
        doi: 10.3390/ijms23168949pubmed: 36012214google scholar: lookup
      18. Anderson JR, Jacobsen S, Walters M, Bundgaard L, Diendorfer A, Hackl M, Clarke EJ, James V, Peffers MJ. Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis.. Front Vet Sci 2022;9:901269.
        doi: 10.3389/fvets.2022.901269pubmed: 36003409google scholar: lookup
      19. Nordberg RC, Otarola GA, Wang D, Hu JC, Athanasiou KA. Navigating regulatory pathways for translation of biologic cartilage repair products.. Sci Transl Med 2022 Aug 24;14(659):eabp8163.
        doi: 10.1126/scitranslmed.abp8163pubmed: 36001677google scholar: lookup
      20. Kearney CM, Khatab S, van Buul GM, Plomp SGM, Korthagen NM, Labbertu00e9 MC, Goodrich LR, Kisiday JD, Van Weeren PR, van Osch GJVM, Brama PAJ. Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation.. Front Vet Sci 2022;9:907616.
        doi: 10.3389/fvets.2022.907616pubmed: 35812845google scholar: lookup
      21. Andersen C, Jacobsen S, Walters M, Lindegaard C. A detailed macroscopic scoring system for experimental post-traumatic Osteoarthritis in the equine middle carpal joint.. BMC Res Notes 2022 Jun 27;15(1):226.
        doi: 10.1186/s13104-022-06116-xpubmed: 35761416google scholar: lookup
      22. Gilbertie JM, Schaer TP, Engiles JB, Seiler GS, Deddens BL, Schubert AG, Jacob ME, Stefanovski D, Ruthel G, Hickok NJ, Stowe DM, Frink A, Schnabel LV. A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model.. Front Cell Infect Microbiol 2022;12:895022.
        doi: 10.3389/fcimb.2022.895022pubmed: 35711655google scholar: lookup
      23. Yamada ALM, do Prado Vendruscolo C, Marsiglia MF, Sotelo EDP, Agreste FR, Seidel SRT, Fu00fclber J, Baccarin RYA, da Silva LCLC. Effects of oral treatment with chondroitin sulfate and glucosamine in an experimental model of metacarpophalangeal osteoarthritis in horses.. BMC Vet Res 2022 Jun 9;18(1):215.
        doi: 10.1186/s12917-022-03323-3pubmed: 35681208google scholar: lookup
      24. Mohd Yunus MH, Lee Y, Nordin A, Chua KH, Bt Hj Idrus R. Remodeling Osteoarthritic Articular Cartilage under Hypoxic Conditions.. Int J Mol Sci 2022 May 11;23(10).
        doi: 10.3390/ijms23105356pubmed: 35628163google scholar: lookup
      25. Andersen C, Uvebrant K, Mori Y, Aarsvold S, Jacobsen S, Berg LC, Lundgren-u00c5kerlund E, Lindegaard C. Human integrin u03b110u03b21-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype.. Stem Cell Res Ther 2022 May 16;13(1):206.
        doi: 10.1186/s13287-022-02884-2pubmed: 35578319google scholar: lookup
      26. Araneda OF. Horse Racing as a Model to Study the Relationship between Air Pollutants and Physical Performance.. Animals (Basel) 2022 Apr 28;12(9).
        doi: 10.3390/ani12091139pubmed: 35565565google scholar: lookup
      27. Menarim BC, El-Sheikh Ali H, Loux SC, Scoggin KE, Kalbfleisch TS, MacLeod JN, Dahlgren LA. Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis.. Front Immunol 2021;12:734322.
        doi: 10.3389/fimmu.2021.734322pubmed: 34956173google scholar: lookup
      28. Durward-Akhurst SA, Schaefer RJ, Grantham B, Carey WK, Mickelson JR, McCue ME. Genetic Variation and the Distribution of Variant Types in the Horse.. Front Genet 2021;12:758366.
        doi: 10.3389/fgene.2021.758366pubmed: 34925451google scholar: lookup
      29. Estrada McDermott J, Pezzanite L, Goodrich L, Santangelo K, Chow L, Dow S, Wheat W. Role of Innate Immunity in Initiation and Progression of Osteoarthritis, with Emphasis on Horses.. Animals (Basel) 2021 Nov 13;11(11).
        doi: 10.3390/ani11113247pubmed: 34827979google scholar: lookup
      30. Clarke EJ, Gillen A, Turlo A, Peffers MJ. An Evaluation of Current Preventative Measures Used in Equine Practice to Maintain Distal Forelimb Functionality: A Mini Review.. Front Vet Sci 2021;8:758970.
        doi: 10.3389/fvets.2021.758970pubmed: 34796229google scholar: lookup
      31. Aru00e9valo-Turrubiarte M, Baratta M, Ponti G, Chiaradia E, Martignani E. Extracellular vesicles from equine mesenchymal stem cells decrease inflammation markers in chondrocytes in vitro.. Equine Vet J 2022 Nov;54(6):1133-1143.
        doi: 10.1111/evj.13537pubmed: 34741769google scholar: lookup
      32. Cokelaere SM, Groen WMGAC, Plomp SGM, de Grauw JC, van Midwoud PM, Weinans HH, van de Lest CHA, Tryfonidou MA, van Weeren PR, Korthagen NM. Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG(1000)]-b-[PLLA] Multi-Block Copolymers in Healthy Horse Joints.. Pharmaceutics 2021 Sep 10;13(9).
        doi: 10.3390/pharmaceutics13091438pubmed: 34575514google scholar: lookup
      33. Menarim BC, MacLeod JN, Dahlgren LA. Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair.. World J Stem Cells 2021 Jul 26;13(7):825-840.
        doi: 10.4252/wjsc.v13.i7.825pubmed: 34367479google scholar: lookup
      34. Pezzanite L, Chow L, Hendrickson D, Gustafson DL, Russell Moore A, Stoneback J, Griffenhagen GM, Piquini G, Phillips J, Lunghofer P, Dow S, Goodrich LR. Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity.. Front Vet Sci 2021;8:676774.
        doi: 10.3389/fvets.2021.676774pubmed: 34095281google scholar: lookup
      35. Kornicka-Garbowska K, Bourebaba L, Ru00f6cken M, Marycz K. Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo.. Cells 2021 Mar 30;10(4).
        doi: 10.3390/cells10040755pubmed: 33808055google scholar: lookup
      36. Fikes KK, Coverdale JA, Leatherwood JL, Campbell JM, Welsh TH Jr, Hartz CJ, Goehring M, Millican AA, Bradbery AN, Wickersham TA. Effect of bioactive proteins on gait kinematics and systemic inflammatory markers in mature horses.. Transl Anim Sci 2021 Jan;5(1):txab017.
        doi: 10.1093/tas/txab017pubmed: 33748684google scholar: lookup
      37. Camargo Garbin L, Morris MJ. A Comparative Review of Autologous Conditioned Serum and Autologous Protein Solution for Treatment of Osteoarthritis in Horses.. Front Vet Sci 2021;8:602978.
        doi: 10.3389/fvets.2021.602978pubmed: 33681323google scholar: lookup
      38. Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases.. Animals (Basel) 2021 Jan 19;11(1).
        doi: 10.3390/ani11010234pubmed: 33477808google scholar: lookup
      39. Castanheira C, Balaskas P, Falls C, Ashraf-Kharaz Y, Clegg P, Burke K, Fang Y, Dyer P, Welting TJM, Peffers MJ. Equine synovial fluid small non-coding RNA signatures in early osteoarthritis.. BMC Vet Res 2021 Jan 9;17(1):26.
        doi: 10.1186/s12917-020-02707-7pubmed: 33422071google scholar: lookup
      40. Rowland AL, Miller D, Berglund A, Schnabel LV, Levine GJ, Antczak DF, Watts AE. Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting.. Stem Cells Transl Med 2021 May;10(5):694-710.
        doi: 10.1002/sctm.20-0435pubmed: 33369287google scholar: lookup
      41. Menarim BC, Gillis KH, Oliver A, Ngo Y, Werre SR, Barrett SH, Rodgerson DH, Dahlgren LA. Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints.. Front Vet Sci 2020;7:568756.
        doi: 10.3389/fvets.2020.568756pubmed: 33324696google scholar: lookup
      42. Copp ME, Flanders MC, Gagliardi R, Gilbertie JM, Sessions GA, Chubinskaya S, Loeser RF, Schnabel LV, Diekman BO. The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence.. Osteoarthritis Cartilage 2021 Mar;29(3):402-412.
        doi: 10.1016/j.joca.2020.11.004pubmed: 33227437google scholar: lookup
      43. Pritchard A, Nielsen BD, Robison C, Manfredi JM. Low dietary silicon supplementation may not affect bone and cartilage in mature, sedentary horses.. J Anim Sci 2020 Dec 1;98(12).
        doi: 10.1093/jas/skaa377pubmed: 33216909google scholar: lookup
      44. Bukowska J, Szu00f3stek-Mioduchowska AZ, Kopcewicz M, Walendzik K, Machciu0144ska S, Gawrou0144ska-Kozak B. Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science.. Stem Cell Rev Rep 2021 Jun;17(3):719-738.
        doi: 10.1007/s12015-020-10049-ypubmed: 33025392google scholar: lookup
      45. Ribitsch I, Baptista PM, Lange-Consiglio A, Melotti L, Patruno M, Jenner F, Schnabl-Feichter E, Dutton LC, Connolly DJ, van Steenbeek FG, Dudhia J, Penning LC. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do.. Front Bioeng Biotechnol 2020;8:972.
        doi: 10.3389/fbioe.2020.00972pubmed: 32903631google scholar: lookup
      46. Chakrabarti S, Ai M, Henson FMD, Smith ESJ. Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for in vitro studies.. Neurobiol Pain 2020 Aug-Dec;8:100051.
        doi: 10.1016/j.ynpai.2020.100051pubmed: 32817908google scholar: lookup
      47. Golonka P, Kornicka-Garbowska K, Marycz K. SIRT1(+) Adipose Derived Mesenchymal Stromal Stem Cells (ASCs) Suspended in Alginate Hydrogel for the Treatment of Subchondral Bone Cyst in Medial Femoral Condyle in the Horse. Clinical Report.. Stem Cell Rev Rep 2020 Dec;16(6):1328-1334.
        doi: 10.1007/s12015-020-10025-6pubmed: 32803696google scholar: lookup
      48. Balaskas P, Green JA, Haqqi TM, Dyer P, Kharaz YA, Fang Y, Liu X, Welting TJM, Peffers MJ. Small Non-Coding RNAome of Ageing Chondrocytes.. Int J Mol Sci 2020 Aug 7;21(16).
        doi: 10.3390/ijms21165675pubmed: 32784773google scholar: lookup
      49. Bertoni L, Jacquet-Guibon S, Branly T, Legendre F, Desancu00e9 M, Mespoulhes C, Melin M, Hartmann DJ, Schmutz A, Denoix JM, Galu00e9ra P, Demoor M, Audigiu00e9 F. An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization.. PLoS One 2020;15(6):e0235251.
        doi: 10.1371/journal.pone.0235251pubmed: 32584901google scholar: lookup
      50. Watkins AR, Reesink HL. Lubricin in experimental and naturally occurring osteoarthritis: a systematic review.. Osteoarthritis Cartilage 2020 Oct;28(10):1303-1315.
        doi: 10.1016/j.joca.2020.05.009pubmed: 32504786google scholar: lookup
      51. Yamada ALM, Pinheiro M, Marsiglia MF, Hagen SCF, Baccarin RYA, da Silva LCLC. Ultrasound and clinical findings in the metacarpophalangeal joint assessment of show jumping horses in training.. J Vet Sci 2020 May;21(3):e21.
        doi: 10.4142/jvs.2020.21.e21pubmed: 32476309google scholar: lookup
      52. Sotelo EDP, Vendruscolo CP, Fu00fclber J, Seidel SRT, Jaramillo FM, Agreste FR, Silva LCLCD, Baccarin RYA. Effects of Joint Lavage with Dimethylsulfoxide on LPS-Induced Synovitis in Horses-Clinical and Laboratorial Aspects.. Vet Sci 2020 Apr 30;7(2).
        doi: 10.3390/vetsci7020057pubmed: 32365982google scholar: lookup
      53. Yassin AM, AbuBakr HO, Abdelgalil AI, Khattab MS, El-Behairy AM, Gouda EM. COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model.. Biomolecules 2020 Feb 26;10(3).
        doi: 10.3390/biom10030354pubmed: 32111016google scholar: lookup
      54. Peal BT, Gagliardi R, Su J, Fortier LA, Delco ML, Nixon AJ, Reesink HL. Synovial fluid lubricin and hyaluronan are altered in equine osteochondral fragmentation, cartilage impact injury, and full-thickness cartilage defect models.. J Orthop Res 2020 Aug;38(8):1826-1835.
        doi: 10.1002/jor.24597pubmed: 31965593google scholar: lookup
      55. Moss KL, Jiang Z, Dodson ME, Linardi RL, Haughan J, Gale AL, Grzybowski C, Engiles JE, Stefanovski D, Robinson MA, Ortved KF. Sustained Interleukin-10 Transgene Expression Following Intra-Articular AAV5-IL-10 Administration to Horses.. Hum Gene Ther 2020 Jan;31(1-2):110-118.
        doi: 10.1089/hum.2019.195pubmed: 31773987google scholar: lookup
      56. Battaglia B, Angelone M, Vera E, Basini G, Bussolati S, Paci M, Bue MD, Aldigeri R, Grolli S, Quintavalla F, Ramoni R. Clinical Effects of the Extract of the Seeds of the Indian Celery-Apium Graveolens-In Horses Affected by Chronic Osteoarthritis.. Animals (Basel) 2019 Aug 20;9(8).
        doi: 10.3390/ani9080585pubmed: 31434330google scholar: lookup
      57. Gilbertie JM, Schnabel LV, Hickok NJ, Jacob ME, Conlon BP, Shapiro IM, Parvizi J, Schaer TP. Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections.. PLoS One 2019;14(8):e0221012.
        doi: 10.1371/journal.pone.0221012pubmed: 31415623google scholar: lookup
      58. Beaulieu A, Linden AZ, Phillips J, Arroyo LG, Koenig J, Monteith G. Various 3D printed materials mimic bone ultrasonographically: 3D printed models of the equine cervical articular process joints as a simulator for ultrasound guided intra-articular injections.. PLoS One 2019;14(8):e0220332.
        doi: 10.1371/journal.pone.0220332pubmed: 31386687google scholar: lookup
      59. Bertoni L, Branly T, Jacquet S, Desancu00e9 M, Desquilbet L, Rivory P, Hartmann DJ, Denoix JM, Audigiu00e9 F, Galu00e9ra P, Demoor M. Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses.. Stem Cells Int 2019;2019:9431894.
        doi: 10.1155/2019/9431894pubmed: 31191689google scholar: lookup
      60. Smit Y, Marais HJ, Thompson PN, Mahne AT, Goddard A. Clinical findings, synovial fluid cytology and growth factor concentrations after intra-articular use of a platelet-rich product in horses with osteoarthritis.. J S Afr Vet Assoc 2019 May 23;90(0):e1-e9.
        doi: 10.4102/jsava.v90i0.1721pubmed: 31170778google scholar: lookup
      61. Lewis R, Gu00f3mez u00c1lvarez CB, Rayman M, Lanham-New S, Woolf A, Mobasheri A. Strategies for optimising musculoskeletal health in the 21(st) century.. BMC Musculoskelet Disord 2019 Apr 11;20(1):164.
        doi: 10.1186/s12891-019-2510-7pubmed: 30971232google scholar: lookup
      62. Feeney E, Peal BT, Inglis JE, Su J, Nixon AJ, Bonassar LJ, Reesink HL. Temporal changes in synovial fluid composition and elastoviscous lubrication in the equine carpal fracture model.. J Orthop Res 2019 May;37(5):1071-1079.
        doi: 10.1002/jor.24281pubmed: 30859611google scholar: lookup
      63. Kornicka K, Al Naem M, Ru00f6cken M, Zmiertka M, Marycz K. Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13.. J Clin Med 2019 Mar 8;8(3).
        doi: 10.3390/jcm8030328pubmed: 30857162google scholar: lookup
      64. Broeckx SY, Martens AM, Bertone AL, Van Brantegem L, Duchateau L, Van Hecke L, Dumoulin M, Oosterlinck M, Chiers K, Hussein H, Pille F, Spaas JH. The use of equine chondrogenic-induced mesenchymal stem cells as a treatment for osteoarthritis: A randomised, double-blinded, placebo-controlled proof-of-concept study.. Equine Vet J 2019 Nov;51(6):787-794.
        doi: 10.1111/evj.13089pubmed: 30815897google scholar: lookup
      65. Macfadyen MA, Daniel Z, Kelly S, Parr T, Brameld JM, Murton AJ, Jones SW. The commercial pig as a model of spontaneously-occurring osteoarthritis.. BMC Musculoskelet Disord 2019 Feb 11;20(1):70.
        doi: 10.1186/s12891-019-2452-0pubmed: 30744620google scholar: lookup
      66. Lepage SIM, Robson N, Gilmore H, Davis O, Hooper A, St John S, Kamesan V, Gelis P, Carvajal D, Hurtig M, Koch TG. Beyond Cartilage Repair: The Role of the Osteochondral Unit in Joint Health and Disease.. Tissue Eng Part B Rev 2019 Apr;25(2):114-125.
        doi: 10.1089/ten.TEB.2018.0122pubmed: 30638141google scholar: lookup
      67. Broeckx SY, Seys B, Suls M, Vandenberghe A, Mariu00ebn T, Adriaensen E, Declercq J, Van Hecke L, Braun G, Hellmann K, Spaas JH. Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.. Stem Cells Dev 2019 Mar 15;28(6):410-422.
        doi: 10.1089/scd.2018.0061pubmed: 30623737google scholar: lookup
      68. Reesink HL, Nixon AJ, Su J, Liu S, Sutton RM, Mann S, Watts AE, Peterson RP. Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis.. Front Vet Sci 2018;5:288.
        doi: 10.3389/fvets.2018.00288pubmed: 30525048google scholar: lookup
      69. Barrachina L, Remacha AR, Romero A, Vitoria A, Albareda J, Prades M, Roca M, Zaragoza P, Vu00e1zquez FJ, Rodellar C. Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis.. BMC Vet Res 2018 Aug 17;14(1):241.
        doi: 10.1186/s12917-018-1556-3pubmed: 30119668google scholar: lookup
      70. Cheng A, Schwartz Z, Kahn A, Li X, Shao Z, Sun M, Ao Y, Boyan BD, Chen H. Advances in Porous Scaffold Design for Bone and Cartilage Tissue Engineering and Regeneration.. Tissue Eng Part B Rev 2019 Feb;25(1):14-29.
        doi: 10.1089/ten.TEB.2018.0119pubmed: 30079807google scholar: lookup
      71. Sladek S, Kearney C, Crean D, Brama PAJ, Tajber L, Fawcett K, Labberte MC, Leggett B, Brayden DJ. Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation.. Drug Deliv Transl Res 2018 Oct;8(5):1421-1435.
        doi: 10.1007/s13346-018-0557-xpubmed: 29947020google scholar: lookup
      72. Bogers SH. Cell-Based Therapies for Joint Disease in Veterinary Medicine: What We Have Learned and What We Need to Know.. Front Vet Sci 2018;5:70.
        doi: 10.3389/fvets.2018.00070pubmed: 29713634google scholar: lookup
      73. Cassano JM, Schnabel LV, Goodale MB, Fortier LA. Inflammatory licensed equine MSCs are chondroprotective and exhibit enhanced immunomodulation in an inflammatory environment.. Stem Cell Res Ther 2018 Apr 3;9(1):82.
        doi: 10.1186/s13287-018-0840-2pubmed: 29615127google scholar: lookup
      74. Castro Martins M, Peffers MJ, Lee K, Rubio-Martinez LM. Effects of stanozolol on normal and IL-1u03b2-stimulated equine chondrocytes in vitro.. BMC Vet Res 2018 Mar 20;14(1):103.
        doi: 10.1186/s12917-018-1426-zpubmed: 29554899google scholar: lookup
      75. Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR. Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor.. Nat Commun 2018 Mar 12;9(1):1037.
        doi: 10.1038/s41467-018-03439-xpubmed: 29531292google scholar: lookup
      76. Morgan RE, Clegg PD, Hunt JA, Innes JF, Tew SR. Interaction with macrophages attenuates equine fibroblast-like synoviocyte ADAMTS5 (aggrecanase-2) gene expression following inflammatory stimulation.. J Orthop Res 2018 Mar 9;36(8):2178-85.
        doi: 10.1002/jor.23891pubmed: 29521434google scholar: lookup
      77. Desancu00e9 M, Contentin R, Bertoni L, Gomez-Leduc T, Branly T, Jacquet S, Betsch JM, Batho A, Legendre F, Audigiu00e9 F, Galu00e9ra P, Demoor M. Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy.. Int J Mol Sci 2018 Feb 10;19(2).
        doi: 10.3390/ijms19020537pubmed: 29439436google scholar: lookup
      78. Bradbery AN, Coverdale JA, Vernon KL, Leatherwood JL, Arnold CE, Dabareiner RA, Kahn MK, Millican AA, Welsh TH Jr. Evaluation of conjugated linoleic acid supplementation on markers of joint inflammation and cartilage metabolism in young horses challenged with lipopolysaccharide.. J Anim Sci 2018 Mar 6;96(2):579-590.
        doi: 10.1093/jas/skx076pubmed: 29385470google scholar: lookup
      79. Labens R, Daniel C, Hall S, Xia XR, Schwarz T. Effect of intra-articular administration of superparamagnetic iron oxide nanoparticles (SPIONs) for MRI assessment of the cartilage barrier in a large animal model.. PLoS One 2017;12(12):e0190216.
        doi: 10.1371/journal.pone.0190216pubmed: 29287105google scholar: lookup
      80. Ball AN, Donahue SW, Wojda SJ, McIlwraith CW, Kawcak CE, Ehrhart N, Goodrich LR. The challenges of promoting osteogenesis in segmental bone defects and osteoporosis.. J Orthop Res 2018 Jun;36(6):1559-1572.
        doi: 10.1002/jor.23845pubmed: 29280510google scholar: lookup
      81. Frondoza CG, Fortuno LV, Grzanna MW, Ownby SL, Au AY, Rashmir-Raven AM. u03b1-Lipoic Acid Potentiates the Anti-Inflammatory Activity of Avocado/Soybean Unsaponifiables in Chondrocyte Cultures.. Cartilage 2018 Jul;9(3):304-312.
        doi: 10.1177/1947603516686146pubmed: 29156944google scholar: lookup
      82. Rakic R, Bourdon B, Hervieu M, Branly T, Legendre F, Saulnier N, Audigiu00e9 F, Maddens S, Demoor M, Galera P. RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation.. Int J Mol Sci 2017 Aug 24;18(9).
        doi: 10.3390/ijms18091842pubmed: 28837082google scholar: lookup
      83. Joswig AJ, Mitchell A, Cummings KJ, Levine GJ, Gregory CA, Smith R 3rd, Watts AE. Repeated intra-articular injection of allogeneic mesenchymal stem cells causes an adverse response compared to autologous cells in the equine model.. Stem Cell Res Ther 2017 Feb 28;8(1):42.
        doi: 10.1186/s13287-017-0503-8pubmed: 28241885google scholar: lookup
      84. Zayed M, Caniglia C, Misk N, Dhar MS. Donor-Matched Comparison of Chondrogenic Potential of Equine Bone Marrow- and Synovial Fluid-Derived Mesenchymal Stem Cells: Implications for Cartilage Tissue Regeneration.. Front Vet Sci 2016;3:121.
        doi: 10.3389/fvets.2016.00121pubmed: 28149840google scholar: lookup
      85. Bertuglia A, Pagliara E, Grego E, Ricci A, Brkljaca-Bottegaro N. Pro-inflammatory cytokines and structural biomarkers are effective to categorize osteoarthritis phenotype and progression in Standardbred racehorses over five years of racing career.. BMC Vet Res 2016 Nov 8;12(1):246.
        doi: 10.1186/s12917-016-0873-7pubmed: 27821120google scholar: lookup
      86. Delco ML, Kennedy JG, Bonassar LJ, Fortier LA. Post-traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches.. J Orthop Res 2017 Mar;35(3):440-453.
        doi: 10.1002/jor.23462pubmed: 27764893google scholar: lookup
      87. Boere J, van de Lest CH, Libregts SF, Arkesteijn GJ, Geerts WJ, Nolte-'t Hoen EN, Malda J, van Weeren PR, Wauben MH. Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles.. J Extracell Vesicles 2016;5:31751.
        doi: 10.3402/jev.v5.31751pubmed: 27511891google scholar: lookup
      88. Reesink HL, Watts AE, Mohammed HO, Jay GD, Nixon AJ. Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis.. Osteoarthritis Cartilage 2017 Jan;25(1):128-137.
        doi: 10.1016/j.joca.2016.07.021pubmed: 27498214google scholar: lookup
      89. Byron CR. Specialty Grand Challenge in Veterinary Surgery and Anesthesiology.. Front Vet Sci 2015;2:19.
        doi: 10.3389/fvets.2015.00019pubmed: 26664948google scholar: lookup
      90. Stefaniuk M, Ropka-Molik K. RNA sequencing as a powerful tool in searching for genes influencing health and performance traits of horses.. J Appl Genet 2016 May;57(2):199-206.
        doi: 10.1007/s13353-015-0320-7pubmed: 26446669google scholar: lookup
      91. Collins JA, Moots RJ, Clegg PD, Milner PI. Resveratrol and N-acetylcysteine influence redox balance in equine articular chondrocytes under acidic and very low oxygen conditions.. Free Radic Biol Med 2015 Sep;86:57-64.
        doi: 10.1016/j.freeradbiomed.2015.05.008pubmed: 25998424google scholar: lookup
      92. Goodrich LR, Grieger JC, Phillips JN, Khan N, Gray SJ, McIlwraith CW, Samulski RJ. scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy.. Gene Ther 2015 Jul;22(7):536-45.
        doi: 10.1038/gt.2015.21pubmed: 25902762google scholar: lookup
      93. Tnibar A, Schougaard H, Camitz L, Rasmussen J, Koene M, Jahn W, Markussen B. An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: a 24 months follow-up.. Acta Vet Scand 2015 Apr 15;57(1):20.
        doi: 10.1186/s13028-015-0110-6pubmed: 25887429google scholar: lookup
      94. Peffers MJ, McDermott B, Clegg PD, Riggs CM. Comprehensive protein profiling of synovial fluid in osteoarthritis following protein equalization.. Osteoarthritis Cartilage 2015 Jul;23(7):1204-13.
        doi: 10.1016/j.joca.2015.03.019pubmed: 25819577google scholar: lookup
      95. Peffers MJ, Cillero-Pastor B, Eijkel GB, Clegg PD, Heeren RM. Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage.. Arthritis Res Ther 2014 May 9;16(3):R110.
        doi: 10.1186/ar4560pubmed: 24886698google scholar: lookup
      96. Peffers M, Liu X, Clegg P. Transcriptomic signatures in cartilage ageing.. Arthritis Res Ther 2013 Aug 23;15(4):R98.
        doi: 10.1186/ar4278pubmed: 23971731google scholar: lookup

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