Brain, behavior, and immunity.
Publisher:
Academic Press,. Amsterdam : Elsevier (2000)
Frequency: Six no. a year 2002-
Country: Netherlands
Language: English
Author(s):
Psychoneuroimmunology Research Society.
Start Year:1987 -
ISSN:
0889-1591 (Print)
1090-2139 (Electronic)
0889-1591 (Linking)
1090-2139 (Electronic)
0889-1591 (Linking)
Impact Factor
15.1
2022
| NLM ID: | 8800478 |
| (DNLM): | SR0057933(s) |
| (OCoLC): | 13800590 |
| Coden: | BBIMEW |
| Classification: | W1 BR113B |
Acute systemic inflammation transiently synchronizes clock gene expression in equine peripheral blood. Peripheral clocks receive timing signals from the master mammalian pacemaker in the suprachiasmatic nucleus (SCN) and function to adaptively anticipate daily changes that influence local physiology. Evidence suggests that peripheral immune activation may act as a resetting signal for circadian clocks in peripheral tissues. We wished to investigate whether acute systemic inflammation could synchronize clock gene expression in equine peripheral blood, a tissue that does not normally oscillate in this species. We report that in vivo administration of lipopolysaccharide (LPS) results in significan...