Cancer letters.
Publisher:
Elsevier/North-Holland.. Limerick : Elsevier Science Ireland
Frequency: Twenty six no. a year
Country: Ireland
Language: English
Start Year:1975 -
ISSN:
0304-3835 (Print)
1872-7980 (Electronic)
0304-3835 (Linking)
1872-7980 (Electronic)
0304-3835 (Linking)
Impact Factor
9.7
2022
| NLM ID: | 7600053 |
| (DNLM): | C05600000(s) |
| (OCoLC): | 01874893 |
| Coden: | CALEDQ |
| LCCN: | 77640685 |
| Classification: | W1 CA68E |
Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids. Equine sarcoids are benign fibroblastic skin tumours affecting equids worldwide. Whilst the pathogenesis is not entirely understood, infection with Bovine Papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in the disease process, however the mechanism by which BPV infection contributes to sarcoid pathology is not clear. In this study, we show that the majority of sarcoids express the BPV-1 major transforming gene E6. Further, we demonstrate that sarcoid lesions are not associated with high levels of cellular proliferation as assessed by Ki67 expression or with expression ...
Analysis of the equine tumor suppressor gene p53 in the normal horse and in eight cutaneous squamous cell carcinomas. Wild type equine p53 was amplified between exons 2 and 9 by the polymerase chain reaction using primers designed from conserved regions in other species. An 828 base pair region, corresponding to codons 25-313 of human p53, was sequenced in both directions. Human and equine amino acid sequences were 87% homologous in this region and 96% homologous in conserved domains II-V. Of eight equine cutaneous or mucocutaneous squamous cell carcinomas directly sequenced from exons 5-8, two had p53 point mutations resulting in single amino acid substitutions.