Cellular and molecular life sciences : CMLS.
Publisher:
Birkhauser,. Basel : Springer
Frequency: Semimonthly, 2004-
Country: Switzerland
Language: English
Start Year:1997 -
ISSN:
1420-682X (Print)
1420-9071 (Electronic)
1420-682X (Linking)
1420-9071 (Electronic)
1420-682X (Linking)
Impact Factor
8
2022
| NLM ID: | 9705402 |
| (DNLM): | SR0089393(s) |
| (OCoLC): | 36457050 |
| Coden: | CMLSFI |
| LCCN: | 97647616 |
| Classification: | W1 EX223 |
A novel uterine lipocalin supporting pregnancy in equids. Horses, donkeys, and therefore, probably all equids, secrete a nonglycosylated, progesterone-dependent, 19-kDa protein (P19) into the uterine lumen during early pregnancy, and significant quantities of it are taken up by the developing conceptus. Sequence analysis and structural modelling have identified P19 as a lipocalin with greatest similarity to the murine major urinary protein lipocalins. However, lack of strong identity with any particular group of lipocalins and several unusual structural features, including a unique amino acid triplet within one of the invariant domains and an unusual...
Melatonin protects mice infected with Venezuelan equine encephalomyelitis virus. We investigated whether the administration of melatonin (MLT) reduces the death rate and evolution of the disease in mice infected with Venezuelan equine encephalomyelitis (VEE) virus. Our results show that, MLT protects mice infected with the virus. The mortality rate was reduced from 100% to 16% merely by increasing the dose from 0 to 1000 micrograms/MLT per kg body weight MLT significantly postponed the onset of the disease and death by several days. In surviving mice very high titres of VEE virus IgM antibodies were found seven weeks after virus inoculation. MLT significantly reduced VEE v...