Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
Publisher:
Elsevier Science,
Frequency: Monthly
Country: United States
Language: English
Start Year:2000 -
ISSN:
1532-0456 (Print)
1532-0456 (Linking)
1532-0456 (Linking)
Impact Factor
3.9
2022
| NLM ID: | 100959500 |
| (OCoLC): | 43977002 |
| LCCN: | 00220265 |
| Classification: | W1 CO435IH |
Developmental toxicity and transcriptome analysis of equine estrogens in developing medaka (Oryzias latipes) using nanosecond pulsed electric field incorporation. Equine estrogens (EQs) are steroidal hormones isolated from the urine of pregnant mares and are used in the formulation of human medications. This study initially investigated the embryonic developmental toxicity of equilin (Eq) and equilenin (Eqn) in medaka (Oryzias latipes). Malformations were observed in embryos exposed to nominal concentrations of 1 and 10 mg/L of Eq and Eqn. Delayed hatching was observed at 1 mg/L of Eq. To further investigate the molecular mechanism of developmental toxicity caused by Eq and Eqn, transcriptome and bioinformatics analyses were performed. Among 2016 and ...