European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V.
Publisher:
Wissenschaftliche Verlagsgesellschaft,. Amsterdam : Elsevier Science
Frequency: Bimonthly
Country: Netherlands
Language: English
Author(s):
Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik.
Start Year:1991 -
ISSN:
0939-6411 (Print)
1873-3441 (Electronic)
0939-6411 (Linking)
1873-3441 (Electronic)
0939-6411 (Linking)
Impact Factor
4.9
2022
| NLM ID: | 9109778 |
| (DNLM): | SR0070914(s) |
| (OCoLC): | 24147951 |
| LCCN: | sn 91033356 |
| Classification: | W1 EU72DPK |
Sustained intra-articular release of celecoxib in an equine repeated LPS synovitis model. Synovial inflammation is an important characteristic of arthritic disorders like osteoarthritis and rheumatoid arthritis. Orally administered non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib are among the most widely prescribed drugs to manage these debilitating diseases. Intra-articular delivery in biodegradable in situ forming hydrogels overcomes adverse systemic effects and prolongs drug retention in the joint. In this study two formulations of celecoxib (40 mg/g and 120 mg/g) in a propyl-capped PCLA-PEG-PCLA triblock copolymer were sequentially evaluated in a multiple L...
Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model. Strangles is an extremely contagious and sometimes deadly disease of the Equidae. The development of an effective vaccine should constitute an important asset to eradicate this worldwide infectious disease. In this work, we address the development of a mucosal vaccine by using a Supercritical Enhanced Atomization (SEA) spray-drying technique. Aqueous solutions containing the Streptococcus equi extracts and chitosan were converted into nanospheres with no use of organic solvents. The immune response in a mouse model showed that the nanospheres induced a well-balanced Th1 and Th2 response charac...