Experimental and therapeutic medicine.
Publisher:
Spandidos Pub.]
Frequency: Bimonthly
Country: Greece
Language: English
Start Year:2010 -
ISSN:
1792-0981 (Print)
1792-1015 (Electronic)
1792-0981 (Linking)
1792-1015 (Electronic)
1792-0981 (Linking)
Impact Factor
2.7
| NLM ID: | 101531947 |
| (OCoLC): | 670238440 |
| LCCN: | 2010243715 |
| Classification: | W1 EX47E |
Methylsulfonylmethane inhibits cortisol-induced stress through p53-mediated SDHA/HPRT1 expression in racehorse skeletal muscle cells: A primary step against exercise stress. Cortisol is a hormone involved in stress during exercise. The application of natural compounds is a new potential approach for controlling cortisol-induced stress. Tumour suppressor protein p53 is activated during cellular stress. Succinate dehydrogenase complex subunit A () and hypoxanthine phosphoribosyl transferase 1 () are considered to be two of the most stable reference genes when measuring stress during exercise in horses. In the present study cells were considered to be in a 'stressed state' if the levels of these stable genes and the highly stress responsive gene p53 were altered. It ...