Glia.
Publisher:
Alan R. Liss, Inc.,. New York, NY : Wiley-Liss
Frequency: 14 no. a year, 1999-
Country: United States
Language: English
Start Year:1988 -
ISSN:
0894-1491 (Print)
1098-1136 (Electronic)
0894-1491 (Linking)
1098-1136 (Electronic)
0894-1491 (Linking)
Impact Factor
6.2
2022
| NLM ID: | 8806785 |
| (DNLM): | SR0060244(s) |
| (OCoLC): | 15804228 |
| Coden: | GLIAEJ |
| Classification: | W1 GL362R |
Differential expression of inwardly rectifying K+ channels and aquaporins 4 and 5 in autoimmune uveitis indicates misbalance in Müller glial cell-dependent ion and water homeostasis. Reactive gliosis is a well-established response to virtually every retinal disease. Autoimmune uveitis, a sight threatening disease, is characterized by recurrent relapses through autoaggressive T-cells. The purpose of this study was to assess retinal Müller glial cell function in equine recurrent uveitis (ERU), a spontaneous disease model resembling the human disease, by investigating membrane proteins implicated in ion and water homeostasis. We found that Kir2.1 was highly expressed in diseased retinas, whereas Kir4.1 was downregulated in comparison to controls. Distribution of Kir2.1 appea...
Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels. In the present study the distribution of astrocytes in the nerve fiber layer (NFL) has been studied in the sparsely vascularized retinae of the guinea pig and horse and in the richly vascularized retina of the Old World monkey (Cercopithecus aethiops) using immunocytochemical methods. In the guinea pig retina glial fibrillary acidic protein (GFAP)-positive astrocytes could not be detected. They were found, however, in the myelinated region of the optic nerve. The optic nerve head and a small retinal region immediately adjacent to it contained few vimentin-positive astrocytes. Histological sect...