Haematologica.
Publisher:
Ferrata Storti Foundation. Pavia, Italy : Ferrata Storti Foundation (1999)
Frequency: Monthly, 1998-
Country: Italy
Language: Italian
Start Year:1920 -
ISSN:
0390-6078 (Print)
1592-8721 (Electronic)
0390-6078 (Linking)
1592-8721 (Electronic)
0390-6078 (Linking)
Impact Factor
10.1
2022
NLM ID: | 0417435 |
(OCoLC): | 01118753 |
(DNLM): | H00160000(s) |
Coden: | HAEMAX |
LCCN: | sn 83004856 |
Classification: | W1 HA156 |
Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia. A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe aplastic anemia. We performed a phase II study of rabbit anti-thymocyte globulin and cyclosporine as first-line therapy for severe aplastic anemia. Methods: Twenty patients with severe aplastic anemia treated with rabbit anti-thymocyte globulin were compared to 67 historical control cases with matched clinical characteristics treated with horse anti-thymocyte globulin. Results: Response rates at 3, 6 and 12 months were similar for patients treated with rabbit anti-thymocyte glob...
Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine. Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and are present in about 40-50% of patients with severe aplastic anemia. Flow cytometry has allowed for sensitive and precise measurement of glycosylphosphatidylinositol-anchor protein-deficient red blood cells and neutrophils in severe aplastic anemia. Methods: We conducted a retrospective analysis of paroxysmal nocturnal hemoglobinuria clones measured by flow cytometry in 207 consecutive severe aplastic anemia patients who received immunosuppressive therapy with a h...