International journal of immunogenetics.
Publisher:
Blackwell Pub.,
Frequency: Bimonthly
Country: England
Language: English
Author(s):
British Society for Histocompatibility and Immunogenetics.
Start Year:2005 -
ISSN:
1744-3121 (Print)
1744-313X (Electronic)
1744-3121 (Linking)
1744-313X (Electronic)
1744-3121 (Linking)
Impact Factor
2.2
2022
| NLM ID: | 101232337 |
| (OCoLC): | 57682036 |
| LCCN: | 2005243193 |
| Classification: | W1 EU72DFJ |
Immunity-related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals. In previous work, we found significant associations of horse polymorphic microsatellite and immunity-related (IR) gene markers with Rhodococcus equi infection of foals. Here, a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden in transtracheal aspirates was found (Fisher's F = 0.043, odds ratio: 8.00, 95% confidence interval: 1.127-56.795). Further positional and/or functional candidate genes investigated TLR2, IL13, IL17A, IL28R, TACE/ADAM 17 and GBP1, were not associated with in...
Single nucleotide polymorphisms in four functionally related immune response genes in the horse: CD14,TLR4, Cepsilon, andFcepsilon R1 alpha. The objective of this study was to identify single nucleotide polymorphisms (SNPs) within four functionally related immune response genes in the horse, and to develop genotyping techniques that could be useful for future genomic studies of horse infectious and allergic diseases. The genes analysed were: the lipopolysaccharide (LPS) receptor gene CD14, the toll-like receptor 4 gene TLR4, the gene Cepsilon encoding the IgE heavy chain molecule and the gene FcepsilonR1 alpha coding for the alpha subunit of the IgE receptor molecule. Horse-specific primers amplifying selected gene regions were des...
Polymorphisms of the upstream regulatory region of the major histocompatibility complex DRB genes in domestic horses. Sequence information was obtained on the variation of the ELA-DRB upstream regulatory region (URR) after polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) cloning and sequencing of approximately 220 bp upstream of the first exon of horse DRB genes. The sequence of the proximal URR of equine DRB is composed of highly conserved sequence motifs, showing the presence of the W, X, Y, CAAT and TATA conserved boxes of major histocompatibility complex (MHC) class II promoters. Five different polymorphic horse DRB promoter sequences were detected in five horse breeds. The res...