International journal of impotence research.
Publisher:
Smith-Gordon,. Basingstoke : Nature Publishing Group
Frequency: Bimonthly, 1999-
Country: England
Language: English
Author(s):
International Society for Impotence Research.
Start Year:1989 -
ISSN:
0955-9930 (Print)
1476-5489 (Electronic)
0955-9930 (Linking)
1476-5489 (Electronic)
0955-9930 (Linking)
Impact Factor
2.6
2022
| NLM ID: | 9007383 |
| (DNLM): | SR0066465(s) |
| (OCoLC): | 21592203 |
| Coden: | IJIRFB |
| LCCN: | sn 90031214 |
| Classification: | W1 IN768T |
Immunohistochemical and functional evidence for a noradrenergic regulation in the horse penile deep dorsal vein. Our aim was to study the presence of noradrenergic nerves and to characterize the alpha-adrenergic receptors involved in the contractions to electrical field stimulation and to alpha-adrenergic agonists of the horse penile deep dorsal vein. Noradrenergic fibres were visualized by immunohistochemistry using an antibody against dopamine-beta-hydroxylase (DBH). For functional studies, the responses of the venous rings to electrical field stimulation and to alpha-adrenergic agonists (noradrenaline, phenylephrine and BHT 920) were studied in the absence and the presence of noradrenergic transmissio...
Contractile response of horse deep dorsal penile vein to histamine. The present investigation was designed to evaluate the effect of histamine on isolated rings of horse deep dorsal penile vein. Under precontracted or basal conditions, histamine evoked an endothelium-independent contraction. Preincubation of the vein rings with the selective H1 receptor antagonist, mepyramine, shifted the concentration-response curve for histamine and to the H1 receptor agonist 2-pyridylethylamine to the right in a competitive manner. Pretreatment with cimetidine, a specific H2 receptor antagonist, did not modify the pEC50 and maximal contraction of the histamine response. Cim...