International journal of pharmaceutics.
Publisher:
Elsevier/North-Holland Biomedical Press.
Frequency: 38 no. a year, 2000-
Country: Netherlands
Language: English
Start Year:1978 -
ISSN:
0378-5173 (Print)
1873-3476 (Electronic)
0378-5173 (Linking)
1873-3476 (Electronic)
0378-5173 (Linking)
Impact Factor
5.8
2022
| NLM ID: | 7804127 |
| (DNLM): | I27700000(s) |
| (OCoLC): | 03687036 |
| Coden: | IJPHDE |
| LCCN: | sc 80000643 |
| Classification: | W1 IN771T |
Clinical evaluation of freeze-dried secretome (lyosecretome) for osteoarthritis: a controlled trial in dogs and preliminary safety assessment in horses. Most in vivo studies on MSC-secretome for osteoarthritis (OA) have relied on animal models, using products lacking pharmaceutical quality, not formulated for clinical use, and insufficiently characterized, limiting knowledge of its effectiveness. This study reports veterinary clinical trials on dogs and horses with spontaneous OA: in dogs (26 subjects), the trial is randomized, double-blinded, and controlled; in horses, 5 clinical cases were treated for safety assessment. Treatment consisted of hyaluronic acid with either lyosecretome - a freeze-dried, injectable MSC-secretome obtained through...
Surface modified polymeric nanoparticles for immunisation against equine strangles. The successful development of particulate vaccines depends on the understanding of their physicochemical and biological characteristics. Therefore, the main purpose of this study was to develop and characterise stable surface modified poly(lactic acid) (PLA) nanoparticles, using polyvinyl alcohol (PVA), alginate (ALG) and glycolchitosan (GCS) containing a Streptococcus equi enzymatic extract adsorbed onto the surface. The characterisation of the preparations and a physicochemical study of the adsorption process were performed. The adsorption of S. equi proteins is a rapid process reaching, wit...