International scholarly research notices.
Discontinued
Publisher:
Hindawi Publishing Corporation,
Country: United States
Language: English
Start Year:2014 - 2017
Identifiers
| ISSN: | 2356-7872 (Electronic) 2356-7872 (Linking) |
| NLM ID: | 101641951 |
| (OCoLC): | 888051655 |
| LCCN: | 2014222076 |
| Classification: | W1 |
Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukin-1 β -Induced MMP-2 Expression in Equine Chondrocyte Culture. Cartilage erosion in degenerative joint diseases leads to lameness in affected horses. It has been reported that andrographolide from Andrographis paniculata inhibited cartilage matrix-degrading enzymes. This study aimed to explore whether this compound protects equine cartilage degradation in the explant culture model and to determine its effect on matrix metalloproteinase-2 (MMP-2) expression, a matrix-degrading enzyme, in equine chondrocyte culture. Equine articular cartilage explant culture was induced by 25 ng/mL interleukin-1β, a key inducer of cartilage degeneration, in cultures with...