Journal of chromatography. B, Biomedical applications.
Discontinued
Publisher:
Elsevier,
Frequency: Twenty eight no. a year
Country: Netherlands
Language: English
Start Year:1994 - 1996
Identifiers
| ISSN: | 1572-6495 (Print) 1879-1794 (Electronic) 1572-6495 (Linking) |
| NLM ID: | 9421796 |
| (DNLM): | SR0079069(s) |
| (OCoLC): | 29859296 |
| Coden: | JCBBEP |
| LCCN: | 94659072 |
| Classification: | W1 JO5845P |
Solid-phase extraction and derivatisation methods for beta-blockers in human post mortem whole blood, urine and equine urine. This paper details various rapid and sensitive methods for the extraction and derivatisation of propranolol, metoprolol, sotalol, atenolol, pindolol, timolol, oxprenolol, alprenolol and penbutolol in equine urine and in human post mortem whole blood and urine. Three solid-phase extraction methods are described involving the use of either XtrackT XRDAH515, Bond Elut Certify or Sep-Pak C18 cartridges. Two derivatisation methods are also described involving the formation of cyclised silyl or pentafluoropropionate derivatives with either chloromethyldimethylchlorosilane or pentafluoropropionic anh...
Determination of phenylbutazone and oxyphenbutazone in plasma and urine samples of horses by high-performance liquid chromatography and gas chromatography-mass spectrometry. A method is described for the qualitative and quantitative determination of phenylbutazone and oxyphenbutazone in horse urine and plasma samples viewing antidoping control. A horse was administered intravenously with 3 g of phenylbutazone. For the qualitative determination, a screening by HPLC was performed after acidic extraction of the urine samples and the confirmation process was realized by GC-MS. Using the proposed method it was possible to detect phenylbutazone and oxyphenbutazone in urine for up to 48 and 120 h, respectively. For the quantitation of these drugs the plasma was deprotein...