Journal of comparative pathology.
Periodical
Pathology
Veterinary Medicine
Veterinary
Publisher:
University Press.. London : Elsevier
Frequency: Eight no. a year
Country: England
Language: English
Start Year:1965 -
ISSN:
0021-9975 (Print)
1532-3129 (Electronic)
0021-9975 (Linking)
1532-3129 (Electronic)
0021-9975 (Linking)
Impact Factor
0.8
2022
| NLM ID: | 0102444 |
| (DNLM): | J17540000(s) |
| (OCoLC): | 01641333 |
| Coden: | JCVPAR |
| LCCN: | sn 80001283 |
| Classification: | W1 JO595H |
The goblet cells of the large colon of the horse.
Journal of comparative pathology
April 1, 1954
Volume 64, Issue 2 97-101 doi: 10.1016/s0368-1742(54)80012-9
MORRIS PG.No abstract available Some observations on general anaesthesia in ponies.
Journal of comparative pathology
January 1, 1954
Volume 64, Issue 1 20-25 doi: 10.1016/s0368-1742(54)80004-x
ALEXANDER F.No abstract available Levels of some chemical constituents in normal horse sera.
Journal of comparative pathology
October 1, 1953
Volume 63, Issue 4 286-293 doi: 10.1016/s0368-1742(53)80030-5
JENNINGS FW, MULLIGAN W.THE chemical analyses reported in this paper arc the result of an investigation on the sera of thirty normal horses from a heavy draught horse stable in Glasgow. Determinations have been made of scrum proteins (albumin and total globulin), alkaline phosphatase, bilirubin, calcium, magnesium, inorganic phosphate and urea. Estimations of some of these constituents have already been carried out by a number of workers, but in the majority of cases the investigation has been confined to one or two constituents relevant to the problem being studied, and many of the data available are a by-product of... Encephalitis in racehorses in Malaya.
Journal of comparative pathology
July 1, 1953
Volume 63, Issue 3 195-198 doi: 10.1016/s0368-1742(53)80023-8
HALE JH, WITHERINGTON DH.No abstract available The characters of streptococci isolated from the uteri of thoroughbred mares in Ireland.
Journal of comparative pathology
October 1, 1952
Volume 62, Issue 4 260-265 doi: 10.1016/s0368-1742(52)80027-x
CRONIN MT.No abstract available Fermentative activities of some members of the normal coccal flora of the horse’s large intestine.
Journal of comparative pathology
October 1, 1952
Volume 62, Issue 4 252-259 doi: 10.1016/s0368-1742(52)80026-8
ALEXANDER F, MACPHERSON MJ, OXFORD AE.No abstract available. The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research.
Journal of comparative pathology
July 11, 2012
Volume 147, Issue 2-3 227-247 doi: 10.1016/j.jcpa.2012.05.010
Patterson-Kane JC, Becker DL, Rich T.The equine superficial digital flexor tendon (SDFT) is a frequently injured structure that is functionally and clinically equivalent to the human Achilles tendon (AT). Both act as critical energy-storage systems during high-speed locomotion and can accumulate exercise- and age-related microdamage that predisposes to rupture during normal activity. Significant advances in understanding of the biology and pathology of exercise-induced tendon injury have occurred through comparative studies of equine digital tendons with varying functions and injury susceptibilities. Due to the limitations of in-... Read More
54
Age patterns of disease and death in insured Swedish dogs, cats and horses.
Journal of comparative pathology
November 25, 2009
Volume 142 Suppl 1 S33-S38 doi: 10.1016/j.jcpa.2009.10.008
Bonnett BN, Egenvall A.From 1995 to the present Agria Animal Insurance, Sweden (Agria Djurförsäkring, Stockholm, Sweden) has provided data on both health care and life insurance claims for descriptive and analytical research. From these data we have published extensively on insured dogs and horses and have recently submitted a study on cat mortality. Over the periods studied most extensively (1995-2002 for dogs, 1997-2004 for horses and 1999-2006 for cats), Agria has insured approximately 200,000 dogs, 100,000 horses and up to 200,000 cats per year. Estimates based on formal research or market surveys suggest that... Read More
44
Immune responsiveness in the neonatal period.
Journal of comparative pathology
June 4, 2007
Volume 137 Suppl 1 S27-S31 doi: 10.1016/j.jcpa.2007.04.008
Morein B, Blomqvist G, Hu K.The maintenance of pregnancy requires suppression of the maternal immune system which would naturally recognize the developing fetus as an allograft and seek to destroy it by mounting a Th1 regulated cytotoxic immune response. During pregnancy a range of soluble factors are produced by the placenta which switch maternal immune regulation towards a protective Th2 phenotype. These factors also influence the developing fetal immune system and all newborns initially have an immunological milieu skewed towards Th2 immunity. Vaccination during the neonatal period must therefore overcome the dual cha... Read More
31
The role of endothelial cell infection in the endometrium, placenta and foetus of equid herpesvirus 1 (EHV-1) abortions.
Journal of comparative pathology
May 1, 1991
Volume 104, Issue 4 379-387 doi: 10.1016/s0021-9975(08)80148-x
Edington N, Smyth B, Griffiths L.One of three mares in the last trimester of pregnancy became paraplegic 7 days after experimental infection with EHV-1 and was killed 10 days after infection (d.p.i.). The other two mares aborted foetuses at 12 and 14 d.p.i. In the first mare, virus was detected by immunofluorescence (IIF) and immunoperoxidase (IP) staining in endothelial cells of the endometrium, placenta and umbilical vein, but not in any other foetal tissues. In the experimentally aborted foetuses, and in two other independent field cases of abortions, endothelial cell infection was also detected in the foetuses, both in ma... Read More
30
A comparison of equid herpesvirus-1 (EHV-1) vascular lesions in the early versus late pregnant equine uterus.
Journal of comparative pathology
April 1, 1996
Volume 114, Issue 3 231-247 doi: 10.1016/s0021-9975(96)80045-4
Smith KC, Mumford JA, Lakhani K.Four Welsh Mountain pony mares at 3 months of gestation and one mare at 5 months were inoculated intranasally with equid herpesvirus-1 (EHV-1: Ab4 isolate) at doses of 10(5) to 10(6.6) TCID50. All five mares became infected, but no cases of paresis or abortion occurred. On days 8, 9, 11, 12 (3-month-pregnant mares) and 13 (5-month-pregnant mare) after infection, a detailed examination of the pregnant uterus was made. Small numbers of vascular lesions with EHV-1 antigen expression in endothelial cells were present in the uteri of the early gestational mares; thrombi were rare and foci of thromb... Read More
18
Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid.
Journal of comparative pathology
September 23, 2008
Volume 139, Issue 4 231-237 doi: 10.1016/j.jcpa.2008.07.006
Equine sarcoids are benign fibroblastic skin tumours that are recognized throughout the world. Infection with bovine papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in disease development; however, the cellular mechanisms underlying fibroblast transformation remain poorly defined. The present study further characterizes aspects of the association with BPV in 15 equine sarcoids. BPV DNA was demonstrated in 12/15 tumours collected from different areas of Italy. Nine of these 12 tumours expressed the BPV oncoproteins E5 and E7, but these oncoproteins were not expressed by... Read More
15
Adhesive properties of platelets from different animal species.
Journal of comparative pathology
March 14, 2003
Volume 128, Issue 2-3 127-131 doi: 10.1053/jcpa.2002.0615
Pelagalli A, Belisario MA, Tafuri S, Lombardi P, d'Angelo D, Avallone L, Staiano N.The use of large animals (e.g., pig and sheep) in human medicine, and the need to develop new therapeutic strategies for domestic animal diseases related to platelet disorders, require better characterization of the physiology of animal platelets. In this study, the ability of platelets from buffaloes, horses, pigs and sheep to adhere to immobilized autologous fibrinogen was compared with that of human platelets. Blood samples were collected from the jugular vein of six healthy subjects of each species and platelet-rich plasma (PRP) was obtained by centrifugation. Platelets, isolated by furthe... Read More
14
Pathology of equine respiratory disease occurring in association with transport.
Journal of comparative pathology
July 1, 1995
Volume 113, Issue 1 29-43 doi: 10.1016/s0021-9975(05)80066-0
Oikawa M, Takagi S, Anzai R, Yoshikawa H, Yoshikawa T.Eight young thoroughbred horses, taken 1858 km by road (travelling time, 41 h), were examined to assess the pathological nature of respiratory disease associated with transport. Three of the horses showed clinical abnormalities including pyrexia, coughing, leucocytosis and neutrophilia after the first 20 h of transportation. Endoscopical examination of the trachea revealed exacerbation of airway inflammation as a result of transport in two of the three affected horses. A consistent finding in the affected horses was focal serous neutrophilic pneumonia affecting the cranio-ventral portion of th... Read More
14
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Journal of comparative pathology
September 9, 2009
Volume 142, Issue 1 61-73 doi: 10.1016/j.jcpa.2009.07.007
Capucchio MT, Márquez M, Pregel P, Foradada L, Bravo M, Mattutino G, Torre C, Schiffer D, Catalano D, Valenza F, Guarda F, Pumarola M.Many age-related changes are described in the nervous system of different species, but detailed studies of brain lesions in ageing horses are lacking. The aim of the present study was to systematically characterize lesions in the brains of 60 horses aged from 7 to 23 years. No gross changes were present in any brain. Microscopically, spongiform changes, lipofuscin storage, corpora amylacea, gliosis and satellitosis were common, together with axonal and neuronal swellings. The most important findings were the presence of pseudocalcium-calcium (pCa-Ca) deposits and arterial wall degeneration. Sc... Read More
14
Immunohistochemical detection of P53 overexpression in paraffin wax-embedded squamous cell carcinomas of cattle, horses, cats and dogs.
Journal of comparative pathology
February 1, 1996
Volume 114, Issue 2 205-210 doi: 10.1016/s0021-9975(96)80010-7
Teifke JP, Löhr CV.One hundred and six squamous cell carcinomas (SCCs) of cattle, horses, cats and dogs were analysed immunohistochemically for overexpression of p53 protein. The monoclonal antibody pAb 240, which recognizes only mutant p53, was used. Of 41 bovine ocular SCCs, 26 (63.4%) showed p53 nuclear reactivity. All of six (100%) equine ocular SCCs and seven of nine (77.7%) SCCs of the equine penis or vulva gave positive reactions. In nine of 11 (81.8%) feline SCCs of the ear and in seven of 14 (50%) feline SCCs of other locations, p53 immunoreactivity was detected. Only seven of 25 (29.5%) canine cutaneou... Read More
14
Twinning as a cause of foetal and neonatal loss in the thoroughbred mare.
Journal of comparative pathology
January 1, 1973
Volume 83, Issue 1 91-106 doi: 10.1016/0021-9975(73)90032-7
Jeffcott LB, Whitwell KE.No abstract available Read More
13
Equine laminitis: comparative histopathology 48 hours after experimental induction with insulin or alimentary oligofructose in standardbred horses.
Journal of comparative pathology
March 22, 2011
Volume 145, Issue 4 399-409 doi: 10.1016/j.jcpa.2011.02.001
de Laat MA, van Eps AW, McGowan CM, Sillence MN, Pollitt CC.Laminitis has many triggers and comparing the histopathology of lesions induced by different causes may help to establish whether a common mechanism or multiple pathologies are involved. The aim of this study was to describe the microscopical lesions and to quantify morphometric changes in the lamellae of horses with insulin-induced (n=4) and oligofructose (OF)-induced laminitis (n=4) compared with normal controls (n=4). Archived lamellar samples collected during two previous studies were used. Laminitis was induced within 48 h in standardbred horses with either a euglycaemic, hyperinsulinaemi... Read More
13
Relationship between onset of puberty and establishment of persistent infection with equine arteritis virus in the experimentally infected colt.
Journal of comparative pathology
July 1, 1993
Volume 109, Issue 1 29-46 doi: 10.1016/s0021-9975(08)80238-1
Holyoak GR, Little TV, McCollam WH, Timoney PJ.The relationship between stage of reproductive tract maturity and susceptibility to the experimental establishment of persistent infection with equine arteritis virus (EAV) was investigated in 21 prepubertal and 15 peripubertal colts. Five of six prepubertal colts inoculated intranasally remained infected in the reproductive tract from post-challenge day 28 to 93 and two of six from post-challenge day 120 to 180. No virus was detected in five of these animals killed on post-challenge day 210. Each of two peripubertal colts remained infected in the reproductive tract at post-challenge day 60 an... Read More
13
Resistance of castrated male horses to attempted establishment of the carrier state with equine arteritis virus.
Journal of comparative pathology
November 1, 1994
Volume 111, Issue 4 383-388 doi: 10.1016/s0021-9975(05)80096-9
McCollum WH, Little TV, Timoney PJ, Swerczek TW.Twelve geldings all became infected when inoculated intranasally with the KY-84 strain of equine arteritis virus (EAV), a strain previously shown to be capable of establishing the carrier state in the stallion. With the exception of one animal that showed no effects other than pyrexia, all of the geldings developed clinical signs characteristic of equine viral arteritis (EVA). The geldings were febrile for varying periods within the range of 2-10 days after inoculation. Viraemia occurred from day 2 onwards, for periods varying from 9 to at least 19 days. Nasal shedding of virus began 2-4 days ... Read More
12
The histological features of the immune system of the equine respiratory tract.
Journal of comparative pathology
September 1, 1987
Volume 97, Issue 5 575-586 doi: 10.1016/0021-9975(87)90008-9
Mair TS, Batten EH, Stokes CR, Bourne FJ.The distribution of mucosa-associated lymphoid tissue along the equine respiratory tract was surveyed in light microscopical sections. Intra-epithelial lymphocytes and similar cells scattered in the lamina propria were identified in all sites from the nasal vestibule to bronchioles of 2 to 4 mm diameter. Isolated lymphoid patches, occasionally with nodules, were common in bronchioles, but the density of this bronchiole-associated lymphoid tissue (BRALT) varied between individual horses. Bronchus-associated lymphoid tissue (BALT) was infrequently encountered. In the upper respiratory tract, nod... Read More
12
Pathology of equine pneumonia associated with transport and isolation of Streptococcus equi subsp. zooepidemicus.
Journal of comparative pathology
August 1, 1994
Volume 111, Issue 2 205-212 doi: 10.1016/s0021-9975(05)80052-0
Oikawa M, Kamada M, Yoshikawa Y, Yoshikawa T.Seven horses that died of pneumonia associated with transport yielded Streptococcus equi subsp. zooepidemicus (S.z.) from their pulmonary lesions. These lesions were divisible roughly into two types, serous haemorrhagic pneumonia and multiple foci of coagulative necrosis, which were considered to reflect a temporal difference in the process of lesion formation. Immunohistologically, S.z. antigen was detected in both types of lesion. Acute necrotic lacunar tonsillitis was considered to play an important role in the onset of the pneumonia. Read More
12
Clinical, virological and serological responses of donkeys to intranasal inoculation with the KY-84 strain of equine arteritis virus.
Journal of comparative pathology
February 1, 1995
Volume 112, Issue 2 207-211 doi: 10.1016/s0021-9975(05)80062-3
McCollum WH, Timoney PJ, Tengelsen LA.The clinical, virological and serological responses of seven female donkeys (Equus asinus) to inoculation with the KY-84 strain of equine arteritis virus (EAV), a strain that causes moderate to severe clinical signs in horses, was investigated. In the donkeys, the only clinical signs observed were fever (mainly 3-9 days after inoculation), mild depression in four animals, and a slight nasal or ocular discharge in three. All of the donkeys became infected with EAV as shown by recovery of the virus for periods of up to 14 days from the nasopharynx and buffy coat and, in three out of four donkeys... Read More
11
Immunosenescence of the equine immune system.
Journal of comparative pathology
November 7, 2009
Volume 142 Suppl 1 S78-S84 doi: 10.1016/j.jcpa.2009.10.007
Horohov DW, Adams AA, Chambers TM.It is widely recognized that advanced age is associated with alterations in immunological responses that likely contribute to increased morbidity and mortality in the elderly population. This decreased efficacy of the immune system with age is referred to as 'immunosenescence' and has been reported for a number of species. Similar age-related changes are seen in horses and are manifested as decreased responsiveness to vaccination in vivo and diminished proliferative responses to mitogens in vitro. The underlying mechanism responsible for these impaired immunological responses remains unknown. ... Read More
11
Studies on grass disease: the morphological picture with special reference to the vegetative nervous system.
Journal of comparative pathology
October 1, 1955
Volume 65, Issue 4 334-346
OBEL AL.No abstract available Read More
10
A comparative study of the histopathology and immunohistochemistry of pythiosis in horses, dogs and cattle.
Journal of comparative pathology
August 6, 2011
Volume 146, Issue 2-3 122-131 doi: 10.1016/j.jcpa.2011.06.006
Martins TB, Kommers GD, Trost ME, Inkelmann MA, Fighera RA, Schild AL.Twenty-one cases of pythiosis in horses (n = 10), dogs (n = 9) and cattle (n = 2) were investigated. The aetiology in all cases was confirmed by immunohistochemistry. Data related to the clinical course and outcome and localization of the lesions were obtained from pathology reports. The equine lesions consisted of fibrotic tissue with multiple, often coalescing, areas of immature granulation tissue encircling eosinophilic cores. Affected dogs had gastrointestinal and/or cutaneous lesions with either or both of a granulomatous/pyogranulomatous or necrotizing eosinophilic inflammatory reaction.... Read More
10
Autonomic neurone degeneration in equine dysautonomia (grass sickness).
Journal of comparative pathology
October 1, 1992
Volume 107, Issue 3 271-283 doi: 10.1016/0021-9975(92)90003-d
Pogson DM, Doxey DL, Gilmour JS, Milne EM, Chisholm HK.Histological investigations were undertaken on four sympathetic autonomic ganglia and on the myenteric and sub-mucosal plexuses of the jejunum in healthy animals, in naturally occurring cases of acute, sub-acute and chronic equine dysautonomia and in ponies in which neuronal damage had been induced by the injection of acute grass sickness sera. The degree of neuronal damage is related to the type of dysautonomia. The coeliac-mesenteric ganglion reacts differently from other ganglia and is less severely damaged in cases of short duration. Extensive experimentally induced damage to the coeliac-m... Read More
10
Effective priming of foals born to immune dams against influenza by a canarypox-vectored recombinant influenza H3N8 vaccine.
Journal of comparative pathology
June 7, 2007
Volume 137 Suppl 1 S76-S80 doi: 10.1016/j.jcpa.2007.04.016
Minke JM, Toulemonde CE, Dinic S, Cozette V, Cullinane A, Audonnet JC.A classical limitation of early life immunization is the interference by maternally derived antibodies, which are known to inhibit the immune response to modified-live and killed vaccines. Several studies have convincingly shown that even minute amounts of maternally derived antibodies against equine influenza can strongly interfere with successful vaccination of foals born to immune mares. In this study we evaluated the response of foals born to vaccinated mares to immunization with a canarypox-vectored recombinant vaccine against equine influenza virus H3N8. The recombinant vaccine was able ... Tumours in large domestic animals in the Netherlands.
Journal of comparative pathology
April 1, 1967
Volume 77, Issue 2 211-216 doi: 10.1016/0021-9975(67)90013-8
Misdorp W.A pathological study of 333 tumours of farm animals in the Netherlands is presented. Most of the tumours (224) were collected at the Amsterdam abattoir over a period of five consecutive years. The incidence of different types of the tumours is compared with figures compiled in the U.S.A. Tumours in cattle and pigs were less frequent in the Amsterdam material than in the U.S.A., but the incidence in horses and sheep was higher than reported elsewhere. Tumours of the jejunum, the ovaries and to a lesser extent of the heart were more frequent, but those of the skin and male genital organs were le... Production and fermentation of lactate by bacteria in the alimentary canal of the horse and pig.
Journal of comparative pathology
January 1, 1963
Volume 73 1-8 doi: 10.1016/s0368-1742(63)80001-6
ALEXANDER F, DAVIES ME.No abstract available Effects of orientation, intermittent rest and vehicle cleaning during transport on development of transport-related respiratory disease in horses.
Journal of comparative pathology
March 2, 2005
Volume 132, Issue 2-3 153-168 doi: 10.1016/j.jcpa.2004.09.006
Oikawa M, Hobo S, Oyamada T, Yoshikawa H.The effects of various factors on the inflammatory and stress response in horses during transportation were examined in Experiments 1 and 2, carried out in April and August, respectively. In Experiment 1, three groups (G1-G3) of four Thoroughbreds were used, and in Experiment 2, two groups (G4, G5). G1 animals were loaded into lorries with their heads facing forwards (FF) and given periods of short rest (SR) (30 min for every 4 h driven). G2 horses were loaded facing rearwards (FR) and given SR. G3 horses were FF and given periods of long rest (LR) (2 h rest for every 4 h driven). G4 horses we... Neurolymphomatosis in three horses with multicentric T-cell-rich B-cell lymphoma.
Journal of comparative pathology
June 7, 2014
Volume 151, Issue 2-3 181-185 doi: 10.1016/j.jcpa.2014.04.004
Lehmbecker A, Liebing J, Barthel Y, Habierski A, Cavalleri J, Puff C, Rademacher B, Lumpe S, Beineke A.Neurolymphomatosis is a rare manifestation of lymphoma and is characterized by neoplastic infiltration of the peripheral nervous system. The present report describes neoplastic infiltration of peripheral nerves in three horses with multicentric lymphoma. Immunohistochemistry revealed the presence of CD79a(+) lymphoblastic cells and well-differentiated CD3(+) T cells, characteristic of T-cell-rich B-cell lymphoma in all cases. Nerve infiltration by lymphoma is rare, but should be considered as a differential diagnosis for peripheral neuropathy in horses with lymphoma. A review of the primary dysautonomias of domestic animals.
Journal of comparative pathology
February 1, 1992
Volume 106, Issue 2 99-119 doi: 10.1016/0021-9975(92)90041-r
Pollin MM, Griffiths IR.Primary dysautonomias appear to be the result of initial damage to the protein synthetic pathway of a specific neuronal population, but despite detailed morphological study of several species there is, as yet, no indication of the precise lesion or the nature of the causal agent. The very marked similarities between the species with regard to lesion type, distribution, the age group affected and the geographical restrictions of occurrence would suggest a very similar, if not common, aetiology. There is no explanation, however, for the 70 year gap between its appearance in horses and its subseq... Studies on passive immunity in the foal. 1. Gamma-globulin and antibody variations associated with the maternal transfer of immunity and the onset of active immunity.
Journal of comparative pathology
January 1, 1974
Volume 84, Issue 1 93-101 doi: 10.1016/0021-9975(74)90031-0
Jeffcott LB.No abstract available Micronema deletrix-induced granulomatous osteoarthritis in a lame horse.
Journal of comparative pathology
October 1, 1988
Volume 99, Issue 3 347-351 doi: 10.1016/0021-9975(88)90056-4
Simpson RM, Hodgin EC, Cho DY.Necropsy of a chronically lame 16-year-old thoroughbred gelding revealed granulomatous osteomyelitis and polyarthritis due to a widely disseminated infection by Micronema deletrix. Diagnosis was based upon the nematode's morphology with its characteristic rhabditiform oesophagus. Granulomata, often containing one or more centrally located M. deletrix, were observed histologically in sections prepared from femur, kidney, stomach, lung, adrenal gland and sublumbar lymph nodes. Neither verminous meningo-encephalitis nor cephalic granulomata, which are the more commonly described lesions, was foun... Investigation of equine influenza cases exhibiting neurological disease: coincidence or association?
Journal of comparative pathology
March 9, 2006
Volume 134, Issue 2-3 231-235 doi: 10.1016/j.jcpa.2005.09.001
Daly JM, Whitwell KE, Miller J, Dowd G, Cardwell JM, Smith KC.Equine influenza is usually a transient and self-limiting disease. However, during an outbreak of equine influenza in the UK in 2003 there were reports of unusually severe clinical signs among unvaccinated animals. Two influenza-infected horses developed neurological signs, and one was subjected to euthanasia. Post-mortem examination of the brain revealed viral-type non-suppurative encephalitis, and influenza virus antigen was demonstrated by immunolabelling of sections of nasal mucosa. A syndrome known as influenza-associated encephalopathy has been described in man. Although not proved, the ...