Journal of dermatological science.
Publisher:
Elsevier,
Frequency: Monthly, 2005-
Country: Netherlands
Language: English
Author(s):
Japanese Society for Investigative Dermatology.
Start Year:1990 -
ISSN:
0923-1811 (Print)
1873-569X (Electronic)
0923-1811 (Linking)
1873-569X (Electronic)
0923-1811 (Linking)
Impact Factor
4.6
2022
| NLM ID: | 9011485 |
| (DNLM): | SR0065829(s) |
| (OCoLC): | 21319893 |
| Coden: | JDSCEI |
| LCCN: | sn 90031284 |
| Classification: | W1 JO619EK |
Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1. Exuberant granulation tissue (EGT), a fibrotic healing disorder resembling the human keloid, occurs almost exclusively in limb wounds of horses and may be caused in part by a relative state of hypoxia within the wound. Objective: The objectives of this study were therefore to (1) assess the effects of hypoxia on equine dermal fibroblast (EDF) proliferation and apoptosis, (2) study the effects of hypoxia on the expression of key extracellular matrix (ECM) associated proteins and determine if such effects are dependent on hypoxia-inducible factor (HIF), and (3) determine if EDFs from the body or...
Equine ANXA2 and MMP1 expression analyses in an experimental model of normal and pathological wound repair. Wounds on horse limbs can develop exuberant granulation tissue which resembles the human keloid. Clues gained from the study of over-scarring in horses might help control fibro-proliferative disorders. Objective: The aim of the present study was to clone full-length equine ANXA2 cDNA then to study spatio-temporal expression of ANXA2 and MMP1 mRNA and protein, potential contributors to remodeling, during repair of body (normal) and limb (fibro-proliferative) wounds in an established horse wound model. Methods: Cloning of ANXA2 was achieved by screening size-selected cDNA libraries. Expression w...