Journal of neuropathology and experimental neurology.
Publisher:
Association of the journal of neuropathology and experimental neurology. Oxford, England : Oxford University Press (2016)
Frequency: Bimonthly
Country: England
Language: English
Author(s):
American Association of Neuropathologists.
Start Year:1942 -
ISSN:
0022-3069 (Print)
1554-6578 (Electronic)
0022-3069 (Linking)
1554-6578 (Electronic)
0022-3069 (Linking)
Impact Factor
3.2
| NLM ID: | 341139 |
| (DNLM): | J31100000(s) |
| (OCoLC): | 01754695 |
| Coden: | JNENAD |
| Classification: | W1 JO793 |
The role of dietary antioxidant insufficiency on the permeability of the blood-brain barrier. Our previous studies implicated vitamin E deficiency as a risk factor for equine motor neuron disease, a possible model of human amyotrophic lateral sclerosis, and showed direct effects of this deficiency on brain vascular endothelium. To gain better understanding of the pathogenesis of equine motor neuron disease, we determined the effects of dietary antioxidant insufficiency and the resultant brain tissue oxidative stress on blood-brain barrier permeability. Rats (n = 40) were maintained on a diet deficient of vitamin E for 36 to 43 weeks; 40 controls were fed a normal diet. Permeability of ...