Journal of peptide science : an official publication of the European Peptide Society.
Publisher:
John Wiley & Sons,
Frequency: Monthly, 1999-
Country: England
Language: English
Author(s):
European Peptide Society.
Start Year:1995 -
ISSN:
1075-2617 (Print)
1099-1387 (Electronic)
1075-2617 (Linking)
1099-1387 (Electronic)
1075-2617 (Linking)
Impact Factor
2.1
2022
| NLM ID: | 9506309 |
| (DNLM): | SR0082411(s) |
| (OCoLC): | 29986337 |
| Coden: | JPSIEL |
| LCCN: | sn 94004855 |
| Classification: | W1 JO828HK |
Anti-biofilm activity of ultrashort cinnamic acid peptide derivatives against medical device-related pathogens. The threat of antimicrobial resistance has placed increasing emphasis on the development of innovative approaches to eradicate multidrug-resistant pathogens. Biofilm-forming microorganisms, for example, Staphylococcus epidermidis and Staphylococcus aureus, are responsible for increased incidence of biomaterial infection, extended hospital stays and patient morbidity and mortality. This paper highlights the potential of ultrashort tetra-peptide conjugated to hydrophobic cinnamic acid derivatives. These peptidomimetic molecules demonstrate selective and highly potent activity against resistant b...
Design of NK-2-derived peptides with improved activity against equine sarcoid cells. Equine sarcoid is a topically accessible model for the evaluation of anticancer peptides acting by physical membrane disruption avoiding the complexity of a systemic application. We aim at evaluating and improving natural peptides for host defence as lead structures, where we focus on the cationic and amphipathic peptide NK-2. Cytotoxicity tests, fluorescence microscopy and a chip-based biosensor, which enabled real-time monitoring of cell metabolism, were applied. Cancer cell killing was dynamic with an initial phase of increased cellular respiration, followed by membrane destruction. NK-2 wa...