Journal of pharmaceutical analysis.
Publisher:
Xi'an Jiaotong University
Frequency: Quarterly
Country: China
Language: English
Author(s):
Xi'an jiao tong da xue.
Start Year:2011 -
ISSN:
2214-0883 (Electronic)
2095-1779 (Print)
2214-0883 (Linking)
2095-1779 (Print)
2214-0883 (Linking)
Impact Factor
8.8
2022
| NLM ID: | 101579451 |
| (OCoLC): | 759000081 |
| LCCN: | 2011250989 |
| Classification: | W1 JO828V |
Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications. Three mesoporous silica excipients (Syloid® silicas AL-1 FP, XDP 3050 and XDP 3150) were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been investigated in previous studies, the effect of inclusion with these specific Syloid® silica based excipients and more interestingly, with phenylbutazone, is unknown. This work reports a significant enhancement for both the extent and rate of drug release for all three forms of Syloid® silica at a ...