The Journal of pharmacy and pharmacology.
Publisher:
Pharmaceutical Society of Great Britain. [Oxford] : Oxford University Press (2021)
Frequency: Monthly
Country: England
Language: English
Author(s):
Pharmaceutical Society of Great Britain., Royal Pharmaceutical Society of Great Britain., British Pharmaceutical Conference., Convegno "Ideologia e scienza nell'opera di Paolo Frisi"
Start Year:1949 -
ISSN:
0022-3573 (Print)
2042-7158 (Electronic)
0022-3573 (Linking)
2042-7158 (Electronic)
0022-3573 (Linking)
Impact Factor
3.765
2022
| NLM ID: | 0376363 |
| (DNLM): | J34620000(s) |
| (OCoLC): | 01754728 |
| Coden: | JPPMAB |
| Classification: | W1 JO831 |
HPLC on Chiralcel OJ-R for enantiomer separation and analysis of ketoprofen, from horse plasma, as the 9-aminophenanthrene derivative. Racemic ketoprofen is a non-steroidal anti-inflammatory drug used to treat musculoskeletal and colic conditions in horses. The enantioselective chiral inversion of ketoprofen administered to horses has been studied by use of cellulose tris(4-methylbenzoate), also known as Chiralcel OJ-R, as chiral stationary phase; acetonitrile - 0.02 M perchlorate buffer (pH 2.0)-methanol, 60:15:25 (v/v/v) was used as mobile phase. Before chromatography, to effect adequate chiral interaction with the chiral stationary phase ketoprofen was derivatized with 9-aminophenanthrene, under acid conditions, after soli...
Dose-related effects of ethylketazocine on nociception, behaviour and autonomic responses in the horse. Sensitive methods for measuring the analgesic, physiological and behavioural effects of opioids in the horse have recently been developed. Fentanyl, a prototypic mu-opiate receptor agonist, has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia, tachypnoea and behavioural arousal. To determine whether other opiate receptors mediate some of the actions of the narcotic analgesics in the horse, an agent with activity at kappa- and to lesser extent mu-receptors was studied using a vigorous experimental protocol. Like fenta...
The uptake of mepacrine by horse polymorphonuclear leucocytes in vitro. The uptake of mepacrine by isolated horse polymorphonuclear leucocytes (PMN) was measured using spectrophotofluorimetry. Two phases of uptake were observed, the first, rapid fraction, essentially complete by 10 min, and a second, slow fraction, which was still proceeding after 60 min. The appearance of mepacrine within the PMN was also visualized by fluorescence microscopy. Discrete yellow points of fluorescence were observed in the cytoplasm of PMN within 30 s. These discrete points corresponded both in size and number to the PMN granules. After 5 min, the nuclei showed faint fluorescence whi...
Effects of trimetaquinol on equine pulmonary vascular and airway smooth muscle. Trimetaquinol [TMQ: 1-(3’,4‘,5’-trimethoxybenzyl)6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride] a potential p-sympathomimetic bronchodilator (Iwasawa & Kiyomoto 1967), has been shown to be an effective tracheal smooth muscle relaxant in guineapigs (Iwasawa & Kiyomoto 1967; Brittain 1972; Brittain et a1 1970, 1976) and an inhibitor of experimental bronchospasm in guinea-pigs and cats (Brittain et a1 1970; Brittain 1972). In addition, clinical studies with TMQ indicated that the drug was an effective bronchodilator in mild to moderate asthma (Yamamura & Kishimoto 1968). It may...
The in vitro adsorption of drugs from horse serum onto carbon coated with an acrylic hydrogel. In vitro studies have shown that uncoated carbon and carbon coated with an acrylic hydrogel are capable of adsorbing drugs from horse serum at 37 degrees. Increase in the coating weight from 2 to 4% decreased the rate of adsorption but not the total capacity. In vivo data supports the concept of carbon haemoperfusion for use in the treatment of drug overdose.
A note on a simple estimation of amphetamine, methylamphetamine and ephedrine in horse urine. A chromatographic separation of amphetamine, methylamphetamine and ephedrine from horse urine is possible on alkaline Silica Gel G plates developed with acetone-methanol (1:3). After elution, the bases are determined colorimetrically. The intensity of the violet colour resulting from the nitration of amphetamine is measured in a Unicam SP1300 colorimeter using filter No. 1 (sensitivity 50–250 μg). The colour produced by the interaction of methylamphetamine, sodium nitro-prusside, acetaldehyde and triethanolamine is measured at 590 mμ (sensitivity 200–2,000 μg). Ephedrine was determined ...