Journal of pharmacological methods.
Discontinued
Publisher:
Elsevier/North-Holland.. New York Ny : Elsevier/north-Holland
Frequency: Eight no. a year
Country: United States
Language: English
Start Year:1978 - 1991
Identifiers
| ISSN: | 0160-5402 (Print) 0160-5402 (Linking) |
| NLM ID: | 7806596 |
| (DNLM): | J34540000(s) |
| (OCoLC): | 03702943 |
| Coden: | JPMED9 |
| Classification: | W1 JO829PS |
Propafenone kinetics in the horse. Comparative analysis of compartmental and noncompartmental models. The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 +/- 211 L) and a high clearance (CI = 7019 +/- 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 microgram/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental...
A method for studying cutaneous pain perception and analgesia in horses. Pain perception and its alteration by analgesic drugs is difficult to measure in the horse. The latency to onset of flexion of a limb in response to a noxious thermal stimulus has been used as a nociceptive end point for analgesic studies in many species. While this method has been employed in the horse, it may be confounded by the spontaneous locomotor activity observed after administration of narcotic analgesics. Consequently, an alternative method of assaying narcotic analgesia that did not involve the equine locomotor apparatus was developed. This report describes the use of the heat-evoke...