Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
Publisher:
The Society,. Krakow : Polish Physiological Society
Frequency: Quarterly
Country: Poland
Language: English
Author(s):
Polskie Towarzystwo Fizjologiczne.
Start Year:1991 -
ISSN:
0867-5910 (Print)
1899-1505 (Electronic)
0867-5910 (Linking)
1899-1505 (Electronic)
0867-5910 (Linking)
Impact Factor
3.011
2020
| NLM ID: | 9114501 |
| (DNLM): | SR0072190(s) |
| (OCoLC): | 24515696 |
| Coden: | JPHPEI |
| Classification: | W1 JO837ABE |
Proliferative processes within the equine corpus luteum may depend on paracrine progesterone actions. Soon after ovulation, the corpus luteum (CL) starts secreting progesterone (P(4)), a hormone necessary for implantation. The aim of the study was to evaluate whether P(4) exerts an autocrine/paracrine action on luteal angiogenic activity and P(4), prostaglandin E(2) (PGE(2)) and NO production in the mare. Corpora hemorrhagica (CH) and mid-luteal phase CL (MCL) were cultured with (i) no hormone (Control); (ii) P(4); (iii) a P(4) precursor - pregnenolone; or (iv) a P(4) antagonist - onapristone [10(-4) M;10(-5) M; all steroids]. NO production decreased in MCL, with respect to CH, when treated wi...