The Journal of rheumatology. Supplement.
Publisher:
Journal of Rheumatology Pub. Co.,
Frequency: Irregular
Country: Canada
Language: English
Start Year:1974 -
Identifiers
| ISSN: | 0380-0903 (Print) 0380-0903 (Linking) |
| NLM ID: | 7806058 |
| (DNLM): | J37280000(s) |
| (OCoLC): | 02443336 |
| Coden: | JRSUDX |
| Classification: | W1 JO87HD |
Viscosupplementation: a new concept in the treatment of osteoarthritis. Viscosupplementation is a new medical concept that has as its therapeutic goal the restoration of rheological homeostasis in pathological structures such as osteoarthritic joints. When the normal viscoelasticity of a solid tissue compartment or the elastoviscosity of a liquid tissue compartment is decreased under pathological conditions, normal function and regenerative processes are impaired. By introducing viscosupplementary devices, the normal rheological state of such compartments is restored or augmented. These devices stay in the tissue compartment for various periods of time, depending ...
Intraarticular hyaluronan injections in the treatment of osteoarthritis: state-of-the-art review. Viscosupplementation (restoring the rheological properties of a tissue matrix) by injection of hyaluronan into the joints has been in use for 2 decades, mostly for osteoarthritis (OA) of the knee, using doses of 20-25 mg of hyaluronan of 500,000 to 2,500,000 M(r), in sequences of 2 to 10 weekly injections. Pain relief appears in a few days, progresses over a few weeks, and often lasts several months. Some data suggest the benefit can last 6 months to one year. Tolerance is universally reported as very good. Those responding to hyaluronan are 65-80%, compared to 30-35% responding to control. Co...