Microbial genomics.
Publisher:
Society for General Microbiology,. [London] : Microbiology Society (2015)
Frequency: Monthly
Country: England
Language: English
Author(s):
Society for General Microbiology,, Microbiology Society,
Start Year:2015 -
ISSN:
2057-5858 (Electronic)
2057-5858 (Linking)
2057-5858 (Linking)
Impact Factor
3.9
2022
| NLM ID: | 101671820 |
| (OCoLC): | 915087449 |
| LCCN: | 2015243491 |
| Classification: | W1 |
Progressive evolution of Streptococcus equi from Streptococcus equi subsp. zooepidemicus and adaption to equine hosts. subsp. causes the equine respiratory disease 'strangles', which is highly contagious, debilitating and costly to the equine industry. emerged from the ancestral subsp. and continues to evolve and disseminate globally. Previous work has shown that there was a global population replacement around the beginning of the twentieth century, obscuring the early genetic events in this emergence. Here, we have used large-scale genomic analysis of and its ancestor to identify evolutionary events, leading to the successful expansion of . One thousand two hundred one whole-genome sequences of were ...
Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses. The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, subspecies , establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such 'carrier' animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of...
Metagenomic sequencing of clinical samples reveals a single widespread clone of Lawsonia intracellularis responsible for porcine proliferative enteropathy. Lawsonia intracellularis is a Gram-negative obligate intracellular bacterium that is the aetiological agent of proliferative enteropathy (PE), a common intestinal disease of major economic importance in pigs and other animal species. To date, progress in understanding the biology of L. intracellularis for improved disease control has been hampered by the inability to culture the organism in vitro. In particular, our understanding of the genomic diversity and population structure of clinical L. intercellularis is very limited. Here, we utilized a metagenomic shotgun approach to directly sequenc...
Identification of genes required for the fitness of Streptococcus equi subsp. equi in whole equine blood and hydrogen peroxide. The availability of next-generation sequencing techniques provides an unprecedented opportunity for the assignment of gene function. subspecies is the causative agent of strangles in horses, one of the most prevalent and important diseases of equids worldwide. However, the live attenuated vaccines that are utilized to control this disease cause adverse reactions in some animals. Here, we employ transposon-directed insertion-site sequencing (TraDIS) to identify genes that are required for the fitness of in whole equine blood or in the presence of HO to model selective pressures exerted by th...