Molecular biology and evolution.
Publisher:
University of Chicago Press,. New York, NY : Oxford University Press (2003)
Frequency: Monthly, 1997-
Country: United States
Language: English
Author(s):
Molecular Biology and Evolution Society., American Society of Naturalists.
Start Year:1983 -
ISSN:
0737-4038 (Print)
1537-1719 (Electronic)
0737-4038 (Linking)
1537-1719 (Electronic)
0737-4038 (Linking)
Impact Factor
10.7
2022
| NLM ID: | 8501455 |
| (DNLM): | M43230000(s) |
| (OCoLC): | 09364605 |
| Coden: | MBEVEO |
| Classification: | W1 MO195R |
Estimating Temporally Variable Selection Intensity from Ancient DNA Data. Novel technologies for recovering DNA information from archaeological and historical specimens have made available an ever-increasing amount of temporally spaced genetic samples from natural populations. These genetic time series permit the direct assessment of patterns of temporal changes in allele frequencies and hold the promise of improving power for the inference of selection. Increased time resolution can further facilitate testing hypotheses regarding the drivers of past selection events such as the incidence of plant and animal domestication. However, studying past selection processes ...
EPAS1 Gain-of-Function Mutation Contributes to High-Altitude Adaptation in Tibetan Horses. High altitude represents some of the most extreme environments worldwide. The genetic changes underlying adaptation to such environments have been recently identified in multiple animals but remain unknown in horses. Here, we sequence the complete genome of 138 domestic horses encompassing a whole altitudinal range across China to uncover the genetic basis for adaptation to high-altitude hypoxia. Our genome data set includes 65 lowland animals across ten Chinese native breeds, 61 horses living at least 3,300 m above sea level across seven locations along Qinghai-Tibetan Plateau, as well as 7...
Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs. Evolution drives changes in a protein's sequence over time. The extent to which these changes in sequence lead to shifts in the underlying preference for each amino acid at each site is an important question with implications for comparative sequence-analysis methods, such as molecular phylogenetics. To quantify the extent that site-specific amino acid preferences shift during evolution, we performed deep mutational scanning on two homologs of human influenza nucleoprotein with 94% amino acid identity. We found that only a modest fraction of sites exhibited shifts in amino acid preferences tha...
Horse domestication and conservation genetics of Przewalski’s horse inferred from sex chromosomal and autosomal sequences. Despite their ability to interbreed and produce fertile offspring, there is continued disagreement about the genetic relationship of the domestic horse (Equus caballus) to its endangered wild relative, Przewalski's horse (Equus przewalskii). Analyses have differed as to whether or not Przewalski's horse is placed phylogenetically as a separate sister group to domestic horses. Because Przewalski's horse and domestic horse are so closely related, genetic data can also be used to infer domestication-specific differences between the two. To investigate the genetic relationship of Przewalski's hors...
Gene conversions in the horse alpha-globin gene complex. The sequences of the linked alpha 2- and alpha 1-globin genes of the equine BI and BII haplotypes are greater than 99% identical within a 1.2-kb region extending from approximately 75 bp upstream of the putative cap site to a point approximately 150 bp 3' to the poly A addition signal. Differences between the alpha 2 and alpha 1 genes that are common to both haplotypes indicate that a major gene conversion occurred approximately 12 Myr ago and that this has been followed by shorter, more localized, conversions. Interhaplotype (allelic) comparisons at the alpha loci suggest that the BI and BII ...