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Molecular & cellular proteomics : MCP.
Publisher:
American Society for Biochemistry and Molecular Biology,. [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology (2021)
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Society for Biochemistry and Molecular Biology.
Start Year:2002 -
ISSN:
1535-9476 (Print)
1535-9484 (Electronic)
1535-9476 (Linking)
1535-9484 (Electronic)
1535-9476 (Linking)
Impact Factor
7.4
2022
| NLM ID: | 101125647 |
| (OCoLC): | 47250252 |
| LCCN: | 2001213374 |
| Classification: | W1 MO194VI |
Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy. Equine grass sickness (EGS) is an acute, predominantly fatal, multiple system neuropathy of grazing horses with reported incidence rates of ∼2%. An apparently identical disease occurs in multiple species, including but not limited to cats, dogs, and rabbits. Although the precise etiology remains unclear, ultrastructural findings have suggested that the primary lesion lies in the glycoprotein biosynthetic pathway of specific neuronal populations. The goal of this study was therefore to identify the molecular processes underpinning neurodegeneration in EGS. Here, we use a bottom-up approach be...
Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry. Autoimmune uveitis is a blinding disease presenting with autoantibodies against eye-specific proteins as well as autoagressive T cells invading and attacking the immune-privileged target tissue retina. The molecular events enabling T cells to invade and attack the tissue have remained elusive. Changes in membrane protein expression patterns between diseased and healthy stages are especially interesting because initiating events of disease will most likely occur at membranes. Since disease progression is accompanied with a break-down of the blood-retinal barrier, serum-derived proteins mask the...
Identification and functional validation of novel autoantigens in equine uveitis. The development, progression, and recurrence of autoimmune diseases are frequently driven by a group of participatory autoantigens. We identified and characterized novel autoantigens by analyzing the autoantibody binding pattern from horses affected by spontaneous equine recurrent uveitis to the retinal proteome. Cellular retinaldehyde-binding protein (cRALBP) had not been described previously as autoantigen, but subsequent characterization in equine recurrent uveitis horses revealed B and T cell autoreactivity to this protein and established a link to epitope spreading. We further immunized h...
