The National medical journal of India.
Publisher:
Published by S. Nundy, produced and distributed by Oxford University Press,. New Delhi : All India Institute Of Medical Sciences
Frequency: Bimonthly
Country: India
Language: English
Start Year:1988 -
ISSN:
0970-258X (Print)
0970-258X (Linking)
0970-258X (Linking)
Impact Factor
0.4
2022
| NLM ID: | 8809315 |
| (DNLM): | SR0060884(s) |
| (OCoLC): | 18467004 |
| Classification: | W1 NA526 |
Is the skin sensitivity test required for administering equine rabies immunoglobulin? Rabies immunoglobulins are life-saving in patients with severe exposure to rabies. Despite the high degree of purification of equine rabies immunoglobulin (ERIG), the product inserts still recommend a skin sensitivity test before administration of this heterologous serum. A recent WHO recommendation states that there are no scientific grounds for performing a skin test before administering ERIG because testing does not predict reactions and it should be given irrespective of the result of the test. In this conflicting situation, we assessed the use of the skin sensitivity test in predicting ad...
Effect of different adjuvants in equines for the production of equine rabies immunoglobulin. Implementation of the recommended post-exposure prophylaxis by vaccination and specific immunoglobulin therapy for rabies is largely hampered by its high cost and inadequate production. Therefore, the development and availability of an economic preparation of rabies immunoglobulin is a high priority for India, where rabies is a major cause of death. We studied the efficacy of four different adjuvants in raising antibodies to rabies antigen in older, discarded equines. Methods: Eleven equines, 23-26 years old, were divided into 4 groups to receive four different adjuvants in small amounts (1-2 ...