Regulatory toxicology and pharmacology : RTP.
Publisher:
Academic Press,. Amsterdam : Elsevier (2003)
Frequency: Bimonthly
Country: Netherlands
Language: English
Start Year:1981 -
ISSN:
0273-2300 (Print)
1096-0295 (Electronic)
0273-2300 (Linking)
1096-0295 (Electronic)
0273-2300 (Linking)
Impact Factor
3.4
2022
| NLM ID: | 8214983 |
| (OCoLC): | 07033938 |
| (DNLM): | R10777000(s) |
| Coden: | RTOPDW |
| LCCN: | 81646304 |
| Classification: | W1 RE173JM |
Seventy day safety assessment of an orally ingested, l-glutamine-containing oat and yeast supplement for horses. We describe a safety assessment of an oral supplement designed to nutritionally support the gastrointestinal system of horses. The supplement comprised a mixture of essential (l-threonine) and conditionally essential (l-glutamine) amino acids, polar lipids, oat bran rich in beta glucans and yeast extract. Young (1-2years) horses of both sexes were allocated to control (n=7) and treatment groups (n=7) and studied for 9weeks. Horses in the treatment group received the supplement daily for 8weeks. After 8weeks of supplementation, horses were studied for one additional week. Outcome measures inclu...
Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. The organophosphate insecticide tetrachlorvinphos (TCVP, Rabon) is the active ingredient in "feed-through" larvacides (e.g., Equitrol) for fly control around horse stables. As with other organophosphates, TCVP elicits toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and cholinergic signs. Relatively little is known, however, on the effects of TCVP-containing larvacides on acetylcholinesterase or other esterases in horses. Previous in vitro studies indicated that horse plasma cholinesterase activity was substantially (>10,000-fold) mo...