Thorax.
Publisher:
British Medical Assn.
Frequency: Monthly
Country: England
Language: English
Author(s):
Association for the Study of Diseases of the Chest., British Medical Association., Thoracic Society.
Start Year:1946 -
ISSN:
0040-6376 (Print)
1468-3296 (Electronic)
0040-6376 (Linking)
1468-3296 (Electronic)
0040-6376 (Linking)
Impact Factor
10
2021
| NLM ID: | 0417353 |
| (DNLM): | T09220000(s) |
| (OCoLC): | 01590818 |
| Coden: | THORA7 |
| Classification: | W1 TH898 |
Inhaled corticosteroids modulate the (+)insert smooth muscle myosin heavy chain in the equine asthmatic airways. Overexpression of the (+)insert smooth muscle myosin heavy chain (SMMHC) isoform could contribute to airway bronchospasm by increasing the velocity of contraction. Whether the (+)insert isoform is present in the small airways and its expression is reversible in asthma are unknown. Objective: To determine the anatomical location and the expression kinetics of the (+)insert SMMHC isoform in airways of horses with heaves and to evaluate its modulation in response to disease status. Methods: We evaluated the (+)insert SMMHC isoform in the airways of horses with heaves during disease exacerbation a...
Enhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway. As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we sought to determine whether asthma is also associated with a GM-CSF dependent increase in lung granulocyte survival. Moreover, because GM-CSF mediates its effects through activation of signal transducer and activator of transcription 5 (STAT5), we also investigated the potential role of STAT5 in allergic inflammation. Methods: Blood granulocytes were recovered from six healthy and six heaves a...
Myocardial atrio-venous junctions and extensions (sleeves) over the pulmonary and caval veins. Anatomical observations in various mammals. The myocardial fibres of the posterior wall of the atrio-venous junctions were examined in 35 large domestic mammals. In the majority of specimens a common pattern in the course and organization of the fibres could be observed. The most obvious features were the following: (1) a main circular fascicle surrounding the pulmonary trunks; (2) fibres encircling the atriovenous junctions; and (3) myocardial sleeves extending along the veins, occasionally as far as the lung. The superior part of the left atrial wall was consistently thicker than the inferior section. Individual variations of this wal...