Tissue engineering.
Discontinued
Publisher:
Mary Ann Liebert, Inc.,
Frequency: Bimonthly, 1999-
Country: United States
Language: English
Author(s):
Tissue Engineering & Regenerative Medicine International Society.
Start Year:1995 - 2007
Identifiers
| ISSN: | 1076-3279 (Print) 1557-8690 (Electronic) 1076-3279 (Linking) |
| NLM ID: | 9505538 |
| (DNLM): | SR0081613(s) |
| (OCoLC): | 30453761 |
| Coden: | TIENFP |
| LCCN: | sn 94005129 |
| Classification: | W1 TI844 |
Suspension of bone marrow-derived undifferentiated mesenchymal stromal cells for repair of superficial digital flexor tendon in race horses. It has been proven that mesenchymal stromal cells (MSCs) can differentiate into tenocytes. Attempts to repair tendon lesions have been performed, mainly using scaffold carriers in experimental settings. In this article, we describe the clinical use of undifferentiated MSCs in racehorses. Significant clinical recovery was achieved in 9 of 11 horses evaluated using ultrasound analysis and their ability to return to racing. Our results show that the suspension of a small number of undifferentiated MSCs may be sufficient to repair damaged tendons without the use of scaffold support. Ultrasound sca...
Alginate encapsulation impacts the insulin-like growth factor-I system of monolayer-expanded equine articular chondrocytes and cell response to interleukin-1beta. Alginate hydrogel culture has been shown to reestablish chondrocytic phenotype following monolayer expansion; however, previous studies have not adequately addressed how culture conditions affect the signaling systems responsible for chondrocyte metabolic activity. Here we investigate whether chondrocyte culture history influences the insulin-like growth factor-I (IGF-I) signaling system and its regulation by interleukin-1 (IL-1). Articular chondrocytes (ACs) from equine stifle joints were expanded by serial passage and were either encapsulated in alginate beads or maintained in monolayer cult...