Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
Publisher:
Nihon Yakugakkai
Frequency: Monthly
Country: Japan
Language: jpn
Author(s):
Nihon Yakugakkai.
Start Year:1881 -
ISSN:
0031-6903 (Print)
1347-5231 (Electronic)
0031-6903 (Linking)
1347-5231 (Electronic)
0031-6903 (Linking)
Impact Factor
0.3
2022
| NLM ID: | 0413613 |
| (OCoLC): | 01762192 |
| (DNLM): | Y00220000(s) |
| Coden: | YKKZAJ |
| Classification: | W1 YA4493 |
[Doping test for racehorses in Japan]. The doping test method used in a horse race requires the accurate detection of a wide variety of drugs and metabolites as well as the rapidity in order to examine a large number of samples within a limited time. For this purpose, the routine method consists of a preliminary screening and a confirmatory test. In this paper, a historical review for the development of the doping test method in Japan is described. The metabolism and pharmacology of drugs in horses are also discussed.
[The effects of crude drugs using diuretic on horse kidney (Na+ + K+)-adenosine triphosphatase]. In the folk-medicine, several kinds of crude drugs are used as diuretics. Twenty three kinds of diuretic drugs were chosen, and examined for their effects on the horse kidney (Na+ + K+)-adenosine triphosphatase (ATPase), which is an intrinsic enzyme of the plasma membrane and responsible for the active transport of Na+ and K+ across the membrane. Twenty one out of twenty three kinds of ethanol extracts of diuretic drugs inhibited the kidney (Na+ + K+)-ATPase activity. The intensity of the inhibition of these drugs was compared by estimating the amounts of their ethanol extracts which inhibited...
[Studies on doping test by gas liquid chromatography-mass spectrometry. I. Detection and identification of sulpyrine, aminopyrine and their metabolites in the horse urine]. When sulpyrine and aminopyrine are administered to the horse, unchanged aminopyrine and its metabolites, 4-methylaminoantipyrine and 4-aminoantipyrine, are detected in the urine by means of thin-layer chromatography (TLC) and gas liquid chromatography. Further identification of aminopyrine and these metabolites was carried out by the gas chromatography-mass spectrometry (GC-MS) method. The procedures for separation and identification are as follows : The excretions were adjusted to pH 9 with ammonium hydroxide and extracted with chloroform. The extract was separated by TLC. The spots were loca...