Topic:Fluconazole
Fluconazole is an antifungal medication used in horses to treat fungal infections. It functions by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting cell membrane integrity and leading to the death of the fungal cells. In equine medicine, fluconazole is often employed to manage conditions such as fungal pneumonia, guttural pouch mycosis, and other systemic mycoses. The pharmacokinetics of fluconazole in horses, including absorption, distribution, metabolism, and excretion, are important considerations for effective dosing and treatment regimens. This page compiles peer-reviewed research studies and scholarly articles that explore the pharmacological properties, therapeutic applications, and clinical outcomes associated with fluconazole use in equine patients.
Sporotrichosis: a retrospective evaluation of 23 cases seen in northern California (1987-2007). Sporotrichosis is an uncommon to rare cutaneous and subcutaneous mycosis of animals and humans caused by the dimorphic fungus Sporothrix schenckii. Twenty-three mammalian cases of sporotrichosis examined between 1987 and 2007 at the University of California, Davis - Veterinary Medical Teaching Hospital, were retrospectively evaluated with regard to the historical, clinical, diagnostic and treatment findings. Cats were the most common species affected (n = 14). In addition, sporotrichosis was diagnosed in four dogs, four horses and a donkey. Six of 23 cases were diagnosed with the localized cut...
Treatment of Coccidioides immitis pneumonia in two horses with fluconazole. Pulmonary coccidioidomycosis in horses can often lead to severe systemic disease and its treatment has previously been expensive and has carried a poor prognosis. This paper describes the successful treatment of two horses with pulmonary coccidioidomycosis with a fluconazole product produced by a compounding pharmacy.
Keratitis due to Histoplasma spp. in a horse. A 5-year-old Holsteiner gelding from Germany was presented 2 months after a whitish discoloration of the left cornea was observed. Cytologic examination revealed intra- and extracellular globular structures, up to 4 micro m in size, consisting of a central spherical deeply basophilic body surrounded by an unstained halo. The structures were morphologically consistent with Histoplasma spp. Infection with Histoplasma organisms is not endemic in Europe. Topical use of fluconazole was successful in eliminating Histoplasma organisms within 10 days of initiation of treatment.
Pharmacokinetics of fluconazole following intravenous and oral administration and body fluid concentrations of fluconazole following repeated oral dosing in horses. To determine the pharmacokinetics of fluconazole in horses. Methods: 6 clinically normal adult horses. Methods: Fluconazole (10 mg/kg of body weight) was administered intravenously or orally with 2 weeks between treatments. Plasma fluconazole concentrations were determined prior to and 10, 20, 30, 40, and 60 minutes and 2, 4, 6, 8, 10, 12, 24, 36, 48, 60, and 72 hours after administration. A long-term oral dosing regimen was designed in which all horses received a loading dose of fluconazole (14 mg/kg) followed by 5 mg/kg every 24 hours for 10 days. Fluconazole concentrations were determined i...
Systemic candidiasis in four foals. Four foals were admitted to the neonatal intensive care unit in the first 2 days of life with problems related to birth hypoxia (neonatal maladjustment syndrome, renal failure, necrotizing enterocolitis) and sepsis. Foals were hospitalized for an extended period (35 to 70 days) and received treatment with several broad spectrum antimicrobial agents. Invasive monitoring and treatment procedures included intravenous catheterization, urinary catheterization, and parenteral nutritional and ventilatory support. In each foal, infections of undetermined cause developed, and systemic candidiasis was d...