Topic:Methadone
Methadone is an opioid analgesic used in veterinary medicine for pain management in horses. It acts on the central nervous system to alleviate moderate to severe pain by binding to opioid receptors. Methadone is sometimes employed in equine practice for its analgesic properties, particularly in cases of colic or after surgical procedures. The pharmacokinetics and pharmacodynamics of methadone in horses are subjects of study to understand its efficacy, dosage, and potential side effects. Research in this area explores the drug's metabolism, duration of action, and impact on equine physiology. This page gathers peer-reviewed research studies and scholarly articles focusing on the application, effects, and safety of methadone in equine medicine.
Objective tests of analgesic drugs in ponies. An equine model, subjected to three kinds of pain (superficial, deep, and visceral) was used to test effects of analgesic drugs. Two groups of ponies were used. In the first group of six ponies, six drugs (fentanyl, meperidine, methadone, oxymorphone, pentazocine, and xylazine) were given according to a Latin square experimental design, and tests were made at 30-minute intervals for 4 hours. Mean values (control) for the three kinds of pain were obtained before and after the tests and were compared with the mean values (drugs) obtained over 2- and 4-hour intervals (four and eight measurements ...
Cardiopulmonary effects of narcotic agonists and a partial agonist in horses. The cardiopulmonary effects of the narcotic agonists morphine, meperidine, oxymorphone, and methadone and of the partial agonist pentazocine were examined in the pain-free adult horse. The drugs produced dysphoric followed by euphoric effects. Increases in heart rate, arterial blood pressure, and cardiac output were observed in all horses with all drugs. Arterial blood pressure remained increased even after heart rate and cardiac output had returned to base-line values. Respiratory rate generally remained unchanged or increased shortly after drug administration and then decreased insignificant...