Metronidazole is an antimicrobial agent commonly used in equine medicine to treat infections caused by anaerobic bacteria and certain protozoal infections. It is often administered in cases of gastrointestinal disturbances, including colitis, due to its efficacy against anaerobic pathogens. The drug works by disrupting the DNA of the microorganisms, leading to their death. Metronidazole is available in various formulations, and its administration must be carefully managed to avoid potential side effects such as neurological symptoms. This page compiles peer-reviewed research studies and scholarly articles that explore the pharmacokinetics, therapeutic applications, and safety considerations of metronidazole in horses.
Kirkpatrick CE, Skand DL.Giardia infection was believed responsible for chronic diarrhea, weight loss, lethargy, inappetence, and dermatitis in a 4-year-old Thoroughbred horse. Fecal cysts were detected by the zinc sulfate centrifugal flotation method. All clinical signs resolved upon treatment with metronidazole suspension (5 mg/kg body weight per os, TID for 10 days).
Zetterström S, Groover E, Lascola K, Cole R, Velloso A, Boone L.A five-year-old Thoroughbred mare was evaluated because of chronic, malodorous, unilateral nasal discharge, and suspected maxillary cheek tooth root abscess. Skull radiographs revealed bilateral sinusitis suspected secondary to tooth root abscessation of 109 and 210. Following oral extraction of 109, bilateral conchofrontal sinus trephination and lavage; fever, tachycardia, and cervical stiffness developed. A lumbosacral cerebrospinal fluid tap was performed, and a presumptive diagnosis of bacterial meningitis was made. Targeted therapy consisted of antibiotic treatment with penicillin, enrofl...
