Topic:Mosaicism
Mosaicism in horses refers to the presence of two or more genetically distinct cell populations within an individual, originating from a single fertilized egg. This phenomenon can occur due to mutations during cell division in the early stages of embryonic development. Mosaicism can affect various aspects of a horse's phenotype, including coat color patterns, and may have implications for genetic inheritance and disease expression. In horses, mosaicism is often identified through genetic testing and can provide insights into developmental biology and genetics. This page compiles peer-reviewed research studies and scholarly articles that explore the mechanisms, detection, and implications of mosaicism in equine genetics and health.
Studies on the chromosomes and sex chromatin in the horse. This study provides accumulated data to assist the definition of karyotypes from normal and infertile horses. The normal karyotype of the horse (2n = 64) was characterized following Giemsa staining and C- banding, and 23% aneuploidy was found among chromosome counts of cells prepared from 44 clinically normal horses and 24 equine embryos. These expected variations in chromosome counts are especially important in the evaluation of potential mosaicism. Centromere staining was shown to be a valuable aid for the identification of specific chromosomes, in particular the sex chromosomes. Sex chromat...
An equine intersex with unilateral gonadal agenesis. Cytogenetic and histological studies have been carried out on an intersex horse which was clinically diagnosed as a cryptorchid. The horse had the general conformation of a stallion but the external genitalia included a well developed vulva and a penis. The right testis which was descended was devoid of germ cells and the left "gonad" located in the cavum vaginale contained neither testicular nor ovarian tissue. The male duct system on both sides were relatively well developed despite the absence of a testis on the left side. Chromosome analysis on cultured cells from the descended testis reve...