Phagocytosis in horses refers to the process by which certain cells, known as phagocytes, engulf and digest foreign particles, bacteria, and cellular debris. This cellular mechanism is a part of the innate immune response, helping to protect horses from infections and maintain tissue homeostasis. Key phagocytic cells in horses include neutrophils and macrophages, which are responsible for identifying and eliminating pathogens. Research on phagocytosis in equines explores the efficiency, regulation, and impact of this process on overall health and disease resistance. This page includes peer-reviewed research studies and scholarly articles that investigate the mechanisms, cellular interactions, and implications of phagocytosis in equine immunology.
Reimann HA.It is conceivable that a change from the virulent, non-phagocytable S form of Pneumococcus to the avirulent phagocytable R form may take place in pneumococcus disease, but the experiments here reported do not settle the question whether or not this is an important factor in determining the outcome in natural infection. It has been shown experimentally that the degradation from the S form to the R form actually does take place in cultures of Pneumococcus growing in agar subcutaneously embedded in guinea pigs, in agar enclosed in vials subcutaneously embedded in rabbits, and spontaneously in the...
Rajesh A, Harman RM, Van de Walle GR.Neutrophil chemotaxis and phagocytosis are critical for protection against bacteria, but can be compromised by methicillin-resistant Staphylococcus aureus (MRSA). MRSA can also circumvent macrophage surveillance by affecting polarization and reactive oxygen species (ROS) production. We previously demonstrated that the secretome of equine mesenchymal stromal cells (MSCs), comprised of all secreted bioactive factors and collected as conditioned medium (CM), reduces the growth of MRSA both in vitro and in vivo. This study aimed to determine if the equine MSC secretome has additional anti-MRSA pro...