Topic:Thiabendazole
Thiabendazole is an anthelmintic agent used in horses to control and treat parasitic worm infections. It functions by interfering with the energy metabolism of parasites, leading to their immobilization and eventual death. Thiabendazole is primarily effective against nematodes, a common type of parasitic worm affecting equines. The compound has been utilized in various formulations, including oral pastes and feed additives, to ensure proper administration and efficacy. Research studies focus on its pharmacokinetics, resistance patterns, and safety profile in horses. This page aggregates peer-reviewed research studies and scholarly articles that explore the usage, effectiveness, and potential side effects of thiabendazole in equine veterinary medicine.
Evaluation of a larval development assay (DrenchRite) for the detection of anthelmintic resistance in cyathostomin nematodes of horses. A larval development assay (LDA, DrenchRite) was evaluated to determine the effectiveness of this method in detecting anthelmintic resistance in cyathostomin nematodes of horses. A total of 15 horse farms from Georgia and South Carolina (USA) and Population S ponies from the University of Kentucky (USA) were included in this study. Nematode eggs were extracted from pooled fecal samples and placed into the wells of a DrenchRite plate for testing against thiabendazole (TBZ), levamisole (LEV) and 2 ivermectin (IVM) analogs (IVM-1, IVM-2). After a 7-day incubation larvae in each well were counted ...
Prevalence of benzimidazole resistance on horse farms in Germany. Faecal egg counts (FECs) were made on samples from 1383 horses on 64 farms in northern Germany between August 2000 and November 2001. There were significant differences between the mean FECs in the two years; in 2000, 59.6 per cent of 369 samples were positive and in 2001, 32.6 per cent of 1014 samples were positive for strongyle eggs. The results of a FEC reduction test indicated that resistance to fenbendazole was present on all 10 farms where it had been used, including in 33 of 60 horses tested. In contrast, treatment with ivermectin resulted in the complete elimination of nematode eggs in...
Strongyle infections in ponies. I. Response to intermittent thiabendazole treatments. A group of seven ponies naturally infected with large numbers of small strongyles and raised under conditions to minimize reinfection were treated periodically over a three year span with thiabendazole at the rate of 44 mg/kg body weight. Based on the absence of worm eggs in the feces following each treatment, thiabendazole removed the adult strongyles present with a new population subsequently developing by maturation of inhibited larvae. It took as many as four or five treatments to eliminate or reduce significantly the worm burdens present in the ponies under the conditions of this study. S...