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Home / Equine Research Bank / Vet Radiol Ultrasound / 18 Fluorine-fluorodeoxyglucose positron emission tomography ...
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association2021; 62(5); 610-620; doi: 10.1111/vru.13001

18 Fluorine-fluorodeoxyglucose positron emission tomography for assessment of deep digital flexor tendinopathy: An exploratory study in eight horses with comparison to CT and MRI.

Abstract: Lesions of the deep digital flexor tendon (DDFT) are a cause for foot lameness in horses. Positron emission tomography (PET) could provide valuable information regarding the metabolic activity of these lesions. The aims of this exploratory, prospective, methods comparison study were to assess the ability of fluorine-fluorodeoxyglucose ( F-FDG) PET to detect DDFT lesions and to compare the PET findings with CT and MRI findings. Eight horses with lameness due to pain localized to the front feet were included. Both front limbs of all horses were imaged with F-FDG PET, noncontrast CT, and arterial contrast-enhanced CT; 11 limbs were also assessed using MRI. Two observers graded independently F-FDG PET, noncontrast CT, arterial contrast CT, T1-weighted (T1-w) MRI, and T2-weighted (T2-w)/STIR MRI. Maximal standardized uptake values were measured. Lesions were found in seven of 16 DDFT on PET, 12 of 16 DDFT on noncontrast CT, six of 15 DDFT on arterial contrast CT, eight of 11 DDFT on T1-w MRI, and six of 11 DDFT on T2-w/STIR MRI. Positron emission tomography was in better agreement with arterial contrast CT (Kappa-weighted 0.40) and T2-w/STIR MRI (0.35) than with noncontrast CT (0.28) and T1-w MRI (0.20). Maximal standardized uptake values of lesions ranged from 1.9 to 4.6 with a median of 3.1. Chronic lesions with scar tissues identified on noncontrast CT or T1-w MRI did not have increased F-FDG uptake. These results demonstrated that F-FDG PET agreed more closely with modalities previously used to detect active tendon lesions, i.e. arterial contrast CT and T2-w/STIR MRI. Fluorine-fluorodeoxyglucose PET can be used to identify metabolically active DDFT lesions in horses.
© 2021 American College of Veterinary Radiology.
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Publication Date: 2021-06-20 PubMed ID: 34148276DOI: 10.1111/vru.13001Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the use of fluorine-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) for diagnosing deep digital flexor tendon (DDFT) injuries in horses, comparing its efficacy with that of CT and MRI scanning. The results suggest that F-FDG PET aligns more closely with CT and MRI in identifying active tendon lesions, suggesting its potential for detecting such injuries in horses.

Fluorine-Fluorodeoxyglucose (F-FDG) PET

  • The study examined the use of F-FDG PET, a type of nuclear medicine image test, to detect DDFT lesions in horses.
  • The objective was to assess F-FDG PET’s ability to detect these lesions and to compare these findings with the results gathered from computed tomography (CT) and magnetic resonance imaging (MRI).
  • The researchers used this method due to its potential to provide valuable information regarding the metabolic activity of DDFT lesions.

Study and Findings

  • The study involved eight horses experiencing lameness due to pain localized in the front feet. It used a prospective, explorative approach where all the front limbs of these horses were imaged using three methods: F-FDG PET, noncontrast CT, and arterial contrast-enhanced CT.
  • Two observers independently graded the images obtained from F-FDG PET, noncontrast and arterial contrast CT, and T1-weighted and T2-weighted/STIR MRI. They also measured the maximal standardized uptake values.
  • The findings indicate that while PET discovered lesions in seven out of 16 DDFT, noncontrast CT found lesions in twelve out of 16, arterial contrast CT found six out of 15, T1-weighted MRI found eight out of 11 and T2-weighted/STIR MRI found six out of 11.
  • F-FDG PET agreed more closely with arterial contrast CT and T2-w/STIR MRI in detecting active tendon lesions than with noncontrast CT or T1-weighted MRI. Chronic lesions marked by scar tissues on noncontrast CT or T1-weighted MRI did not display increased F-FDG uptake.
  • These results suggest that F-FDG PET might be a valuable tool in identifying metabolically active DDFT lesions in horses.

Cite This Article

APA
Wilson S, Spriet M, Mur PE, Anishchenko S, Beylin D, Katzman S, Galuppo L. (2021). 18 Fluorine-fluorodeoxyglucose positron emission tomography for assessment of deep digital flexor tendinopathy: An exploratory study in eight horses with comparison to CT and MRI. Vet Radiol Ultrasound, 62(5), 610-620. https://doi.org/10.1111/vru.13001

Publication

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
ISSN: 1740-8261
NlmUniqueID: 9209635
Country: England
Language: English
Volume: 62
Issue: 5
Pages: 610-620

Researcher Affiliations

Wilson, Sabrina
  • School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Spriet, Mathieu
  • School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Mur, Pablo Espinosa
  • School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Anishchenko, Sergey
  • LONGMILE Veterinary Imaging, Brain Biosciences Inc., Rockville, Maryland, USA.
Beylin, David
  • LONGMILE Veterinary Imaging, Brain Biosciences Inc., Rockville, Maryland, USA.
Katzman, Scott
  • School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
Galuppo, Larry
  • School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

MeSH Terms

  • Animals
  • Fluorine
  • Fluorodeoxyglucose F18
  • Horse Diseases / diagnostic imaging
  • Horses
  • Magnetic Resonance Imaging / veterinary
  • Positron-Emission Tomography / veterinary
  • Prospective Studies
  • Radiopharmaceuticals
  • Tendinopathy / veterinary
  • Tomography, X-Ray Computed

References

This article includes 31 references
  1. Dyson S, Murray R, Schramme M, Branch M. Lameness in 46 horses associated with deep digital flexor tendonitis in the digit: diagnosis confirmed with magnetic resonance imaging. Equine Vet J 2003;35(7):681-690.
    doi: 10.2746/042516403775696294google scholar: lookup
  2. Dyson SJ, Murray R, Schramme MC. Lameness associated with foot pain: results of magnetic resonance imaging in 199 horses (January 2001-December 2003) and response to treatment. Equine Vet J 2005;37(2):113-121.
    doi: 10.2746/0425164054223804google scholar: lookup
  3. Blunden A, Murray R, Dyson S. Lesions of the deep digital flexor tendon in the digit: a correlative MRI and post mortem study in control and lame horses. Equine Vet J 2009;41(1):25-33.
    doi: 10.2746/042516408x343028google scholar: lookup
  4. Sherlock CE, Kinns J, Mair TS. Evaluation of foot pain in the standing horse by magnetic resonance imaging. Vet Rec 2007;161(22):739-744.
    doi: 10.1136/vr.161.22.739google scholar: lookup
  5. Mair TS, Kinns J. Deep digital flexor tendonitis in the equine foot diagnosed by low-field magnetic resonance imaging in the standing patient: 18 cases. Vet Radiol Ultrasound 2005;46(6):458-466.
    doi: 10.1111/j.1740-8261.2005.00084.xgoogle scholar: lookup
  6. Dyson S, Murray R. Magnetic resonance imaging evaluation of 264 horses with foot pain: the podotrochlear apparatus, deep digital flexor tendon and collateral ligaments of the distal interphalangeal joint. Equine Vet J 2007;39(4):340-343.
    doi: 10.2746/042516407x185566google scholar: lookup
  7. Widmer WR, Buckwalter KA, Fessler JF, Hill MA, VanSickle DC, Ivancevich S. Use of radiography, computed tomography and magnetic resonance imaging for evaluation of navicular syndrome in the horse. Vet Radiol Ultrasound 2000;41(2):108-116.
    doi: 10.1111/j.1740-8261.2000.tb01463.xgoogle scholar: lookup
  8. Vallance SA, Bell RJW, Spriet M, Kass PH, Puchalski SM. Comparisons of computed tomography, contrast enhanced computed tomography and standing low-field magnetic resonance imaging in horses with lameness localised to the foot. Part 1: anatomic visualisation scores. Equine Vet J 2012;44(1):51-56.
    doi: 10.1111/j.2042-3306.2011.00372.xgoogle scholar: lookup
  9. Vallance SA, Bell RJW, Spriet M, Kass PH, Puchalski SM. Comparisons of computed tomography, contrast-enhanced computed tomography and standing low-field magnetic resonance imaging in horses with lameness localised to the foot. Part 2: lesion identification. Equine Vet J 2012;44(2):149-156.
    doi: 10.1111/j.2042-3306.2011.00386.xgoogle scholar: lookup
  10. Whitton RC, Buckley C, Donovan T, Wales AD, Dennis R. The diagnosis of lameness associated with distal limb pathology in a horse: a comparison of radiography, computed tomography and magnetic resonance imaging. Vet J 1998;155(3):223-229.
    doi: 10.1016/s1090-0233(05)80014-0google scholar: lookup
  11. Murray RC, Schramme MC, Dyson SJ, Branch MV, Blunden TS. Magnetic resonance imaging characteristics of the foot in horses with palmar foot pain and control horses. Vet Radiol Ultrasound 2006;47(1):1-16.
    doi: 10.1111/j.1740-8261.2005.00100.xgoogle scholar: lookup
  12. Seignour M, Pasquet H, Coudry V, Denoix JM. Ultrasonographic diagnosis of injuries to the deep digital flexor tendon and associated structures in the equine foot (suprasesamoidean area). Equine Vet Educ 2011;23(7):369-376.
    doi: 10.1111/j.2042-3292.2010.00220.xgoogle scholar: lookup
  13. van Hamel SE, Bergman HJ, Puchalski SM, de Groot MW, van Weeren PR. Contrast-enhanced computed tomographic evaluation of the deep digital flexor tendon in the equine foot compared to macroscopic and histological findings in 23 limbs. Equine Vet J 2014;46(3):300-305.
    doi: 10.1111/evj.12129google scholar: lookup
  14. Puchalski SM, Galuppo LD, Drew CP, Wisner ER. Use of contrast-enhanced computed tomography to assess angiogenesis in deep digital flexor tendonopathy in a horse. Vet Radiol Ultrasound 2009;50(3):292-297.
    doi: 10.1111/j.1740-8261.2009.01536.xgoogle scholar: lookup
  15. Vanel M, Olive J, Gold S, Mitchell RD, Walker L. Clinical significance and prognosis of deep digital flexor tendinopathy assessed over time using MRI. Vet Radiol Ultrasound 2012;53(6):621-627.
    doi: 10.1111/j.1740-8261.2012.01961.xgoogle scholar: lookup
  16. Lutter JD, Schneider RK, Sampson SN, Cary JA, Roberts GD, Vahl CI. Medical treatment of horses with deep digital flexor tendon injuries diagnosed with high-field-strength magnetic resonance imaging: 118 cases (2000-2010). J Am Vet Med Assoc 2015;247(11):1309-1318.
    doi: 10.2460/javma.247.11.1309google scholar: lookup
  17. Holowinski M, Judy C, Saveraid T, Maranda L. Resolution of lesions on STIR images is associated with improved lameness status in horses. Vet Radiol Ultrasound 2010;51(5):479-484.
    doi: 10.1111/j.1740-8261.2010.01692.xgoogle scholar: lookup
  18. Schramme M, Kerekes Z, Hunter S, Labens R. Mr imaging features of surgically induced core lesions in the equine superficial digital flexor tendon. Vet Radiol Ultrasound 2010;51(3):280-287.
    doi: 10.1111/j.1740-8261.2009.01660.xgoogle scholar: lookup
  19. Jones ARE, Ragle CA, Mattoon JS, Sanz MG. Use of non-contrast-enhanced computed tomography to identify deep digital flexor tendinopathy in horses with lameness: 28 cases (2014-2016). J Am Vet Med Assoc 2019;254(7):852-858.
    doi: 10.2460/javma.254.7.852google scholar: lookup
  20. Leblanc AK, Jakoby B, Townsend DW, Daniel GB. Thoracic and abdominal organ uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) with positron emission tomography in the normal dog. Vet Radiol Ultrasound 2008;49(2):182-188.
    doi: 10.1111/j.1740-8261.2008.00348.xgoogle scholar: lookup
  21. Parsons MA, Moghbel M, Saboury B. Increased 18F-FDG uptake suggests synovial inflammatory reaction with osteoarthritis: preliminary in-vivo results in humans. Nucl Med Commun 2015;36(12):1215-1219.
    doi: 10.1097/mnm.0000000000000376google scholar: lookup
  22. Wandler E, Kramer EL, Sherman O, Babb J, Scarola J, Rafii M. Diffuse FDG shoulder uptake on PET is associated with clinical findings of osteoarthritis. AJR Am J Roentgenol 2005;185(3):797-803.
    doi: 10.2214/ajr.185.3.01850797google scholar: lookup
  23. Huang SS, Yu JQ, Chamroonrat W, Alavi A, Zhuang H. Achilles tendonitis detected by FDG-PET. Clin Nucl Med 2006;31(3):147-148.
    doi: 10.1097/01.rlu.0000200463.66611.66google scholar: lookup
  24. Eliasson P, Couppé C, Lonsdale M. Ruptured human Achilles tendon has elevated metabolic activity up to 1 year after repair. Eur J Nucl Med Mol Imaging 2016;43(10):1868-1877.
    doi: 10.1007/s00259-016-3379-4google scholar: lookup
  25. Frank I, Mann K, Duerr F. Fluorine-18-fluoro-2-deoxy-d-glucose PET-CT aids in detection of soft-tissue injuries for dogs with thoracic or pelvic limb lameness. Vet Radiol Ultrasound 2019;60(5):575-585.
    doi: 10.1111/vru.12790google scholar: lookup
  26. Spriet M, Espinosa P, Kyme AZ. Positron emission tomography of the equine distal limb: exploratory study. Vet Radiol Ultrasound 2016;57(6):630-638.
    doi: 10.1111/vru.12430google scholar: lookup
  27. AAEP Horse Show Committee. Guide to Veterinary Services for Horse Shows. .
  28. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33(1):159-174.
    doi: 10.2307/2529310google scholar: lookup
  29. McRobbie DW, Moore EA, Graves MJ, Prince MR. MRI From Picture to Proton. .
  30. Spriet M, Espinosa P, Kyme AZ. 18 F-sodium fluoride positron emission tomography of the equine distal limb: exploratory study in three horses. Equine Vet J 2018;50(1):125-132.
    doi: 10.1111/evj.12719google scholar: lookup
  31. Norvall A, Spriet M, Espinosa P. Chondrosesamoidean ligament enthesopathy: prevalence and findings in a population of lame horses imaged with positron emission tomography. Equine Vet J 2021;53:451-459.
    doi: 10.1111/evj.13299google scholar: lookup

Citations

This article has been cited 1 times.
  1. Greco A, Meomartino L, Gnudi G, Brunetti A, Di Giancamillo M. Imaging techniques in veterinary medicine. Part II: Computed tomography, magnetic resonance imaging, nuclear medicine.. Eur J Radiol Open 2023;10:100467.
    doi: 10.1016/j.ejro.2022.100467pubmed: 36570419google scholar: lookup
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