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Home / Equine Research Bank / Vet Q / A field study on the anthelmintic resistance of Parascaris s...
The veterinary quarterly2017; 37(1); 200-205; doi: 10.1080/01652176.2017.1334981

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia.

Abstract: In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. Objective: To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. Methods: Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC). The foals were all Arab horses aged 17.2 ± 4.5 (SD) months. Ivermectin (n = 46 foals), abamectin and praziquantel combined (n = 46), and fenbendazole (n = 46) were administered on day 0 and faeces were collected on day 14. The study comprised 41 untreated foals as controls. Animals that have FEC of ≥100 eggs per gram (EPG) were used to measure anthelmintic efficacy. Parascaris spp. populations were considered susceptible when faecal egg count reduction (FECR) was ≥95% associated with a lower 95% confidence limit (LCL) >90%, suspected resistant when FECR ≤90% or LCL <90% and resistant when FECR <90% and LCL <90%. Results: Prevalence of Parascaris spp. infection was 53% (179/341 horses). Anthelmintic resistance to Parascaris spp. were highest following fenbendazole (55% of farms and 65% of foals) and to a lower extent following ivermectin or the combination of abamectin and praziquantel which comprised 27% of farms (and 46% of foals) and 18% of farms (and 10% of foals), respectively. Conclusions: These data indicate that anthelmintics-resistant Parascaris spp. populations are present on horse farms in Saudi Arabia.
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Publication Date: 2017-05-26 PubMed ID: 28537782DOI: 10.1080/01652176.2017.1334981Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research examines the incidence of resistance to anthelmintic drugs in horse roundworm (Parascaris spp.) among Arab foals in Saudi Arabia. The study found significant resistance, particularly to the drug fenbendazole.

Objective and Methods

  • The study aimed to determine resistance levels among Parascaris spp. to three anthelmintic drugs, namely ivermectin, abamectin and praziquantel combined, and fenbendazole, in Arab horses in Saudi Arabia.
  • A total of 341 Arab horse foals from eleven different farms were enrolled in the study. Faecal egg count (FEC) testing was used to assess the level of roundworm infection.
  • The age of the foals studied was around 17.2 ± 4.5 months. The researchers administered the anthelmintic drugs to groups of the foals (46 per drug) and collected faeces for follow-up study on day 14. Forty-one foals were left untreated to act as controls.
  • The efficacy of the anthelmintic drugs was measured using foals with FEC of ≥100 eggs per gram (EPG). The researchers classified roundworm populations as susceptible, suspected resistant, or resistant based on the post-treatment reduction in FEC and lower 95% confidence limit (LCL).

Results

  • The study found that 53% of the foals had Parascaris spp. infections.
  • Following administration of the anthelmintic drugs, researchers observed the highest levels of resistance to fenbendazole, present in 55% of farms and 65% of foals.
  • Ivermectin showed somewhat lower resistance, detected at 27% of farms and affecting 46% of foals, and abamectin and praziquantel combined was found to have the lowest level of observed resistance, present in 18% of farms and 10% of foals.

Conclusion

  • The results confirm that significant Parascaris spp. resistance to anthelmintics exists among horses in Saudi Arabia. This has potential implications for parasite management strategies on horse farms in the country and indicates a need to consider alternative approaches.

Cite This Article

APA
Alanazi AD, Mukbel RM, Alyousif MS, AlShehri ZS, Alanazi IO, Al-Mohammed HI. (2017). A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia. Vet Q, 37(1), 200-205. https://doi.org/10.1080/01652176.2017.1334981

Publication

The veterinary quarterly
ISSN: 1875-5941
NlmUniqueID: 7909485
Country: England
Language: English
Volume: 37
Issue: 1
Pages: 200-205

Researcher Affiliations

Alanazi, Abdullah D
  • a Department of Biological Science, Faculty of Science and Humanities , Shaqra University , Ad-Dawadimi , Saudi Arabia.
Mukbel, Rami M
  • b Department of Basic Veterinary Medical Sciences, Faculty of Veterinary Medicine , Jordan University of Science and Technology , Irbid , Jordan.
Alyousif, Mohamed S
  • c Department of Zoology, College of Science , King Saud University , Riyadh , Saudi Arabia.
AlShehri, Zafer S
  • a Department of Biological Science, Faculty of Science and Humanities , Shaqra University , Ad-Dawadimi , Saudi Arabia.
Alanazi, Ibrahim O
  • d The National Centre for Genomic Technology , King Abdulaziz City for Science and Technology , Riyadh , Saudi Arabia.
Al-Mohammed, Hamdan I
  • e Department of Microbiology and Medical Parasitology, Faculty of Medicine , King Faisal University , Al Ahsa , Saudi Arabia.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Antinematodal Agents / pharmacology
  • Ascaridida Infections / drug therapy
  • Ascaridida Infections / epidemiology
  • Ascaridida Infections / veterinary
  • Ascaridoidea / drug effects
  • Case-Control Studies
  • Drug Combinations
  • Drug Resistance
  • Feces / parasitology
  • Fenbendazole / pharmacology
  • Horse Diseases / drug therapy
  • Horse Diseases / epidemiology
  • Horses
  • Ivermectin / analogs & derivatives
  • Ivermectin / pharmacology
  • Parasite Egg Count
  • Praziquantel / pharmacology
  • Saudi Arabia / epidemiology

Citations

This article has been cited 9 times.
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