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The Journal of veterinary medical science2002; 64(10); 893-900; doi: 10.1292/jvms.64.893

A gross and histopathological study of an ectopic white line development in equine laminitis.

Abstract: In horses with chronic laminitis, an abnormal horny structure called lamellar wedge, is generated between the hoof wall and the laminar epidermis. To be able to manage horses with chronic laminitis correctly, more information about the pathological state of this abnormal horn is required. The aim of this study was to collect and analyze objective morphological data about the abnormal horn in order to understand its morphology and development. In the study, the abnormal horn was grossly visible on the sagittal hoof section from approximately 20 days after the onset of disease. In the histological observations, the structural characteristics of this abnormal horn were similar to the white line tissue, suggesting it is an ectopic white line. Mean value of the cross-sectional area of the abnormal horn against the distal phalanx section area (A/D) was 0.29 cm(2) SD +/- 0.14 and it finally showed an eight-fold increase over the mean value of normal white line section area against the distal phalanx section area. In conclusion, a large amount of the ectopic white line is thought to be finally able to inhibit normal hoof wall growth, so that it should be resected at the optimum time when would be after one month from the onset of the disease.
Publication Date: 2002-11-07 PubMed ID: 12419865DOI: 10.1292/jvms.64.893Google Scholar: Lookup
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  • Journal Article

Summary

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The research article is an investigation into an abnormal hoof structure that develops in horses suffering from chronic laminitis. The study provides insights into the morphology and development of this structure, termed an ‘ectopic white line’.

Article Explanation and Research Overview

The research paper is a detailed study on the anomaly noticed in the hoof of horses suffering from chronic laminitis, a disease characterized by inflammation of the sensitive layers of tissue beneath the hard outer shell of the horse’s hoof. The abnormality is referred to as the ‘lamellar wedge’, an abnormal horny structure that develops between the hoof wall and the laminar epidermis.

  • The main objective of the study was to gather and scrutinize morphological data of this abnormal structure to better understand its formation and growth.
  • This investigation is important as it provides information necessary to improve management and treatment of equine chronic laminitis.

Research Methodology and Findings

The research conducted a gross and histopathological examination of the hoof anomaly.

  • It was observed that the abnormal horn becomes visible on the sagittal hoof section approximately after 20 days from the onset of the disease.
  • Through histological observations, the structural characteristics of the abnormal horn were found to be similar to white line tissue, thereby classifying it as an ‘ectopic white line’.
  • In the aberrant horn, the cross-sectional area against the distal phalanx section area (A/D) had a mean value of 0.29 cm2, a significant increase from the average value in a normal hoof.

Conclusion and Implications

The study concluded that the ectopic white line contributes significantly to inhibiting normal hoof wall growth.

  • This finding suggests that the abnormal structure should be removed at an optimal time to prevent further impairment of the hoof’s normal growth, ideally after a month from the onset of the disease.
  • The insights from the study are critical in aiding the treatment and management of horses suffering from chronic laminitis, enhancing prospects of their recovery and wellbeing.

Cite This Article

APA
Kuwano A, Katayama Y, Kasashima Y, Okada K, Reilly JD. (2002). A gross and histopathological study of an ectopic white line development in equine laminitis. J Vet Med Sci, 64(10), 893-900. https://doi.org/10.1292/jvms.64.893

Publication

ISSN: 0916-7250
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 64
Issue: 10
Pages: 893-900

Researcher Affiliations

Kuwano, Atsutoshi
  • Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association, Utsunomiya-shi, Tochigi, Japan.
Katayama, Yoshinari
    Kasashima, Yoshinori
      Okada, Kosuke
        Reilly, John D

          MeSH Terms

          • Animals
          • Female
          • Foot Diseases / pathology
          • Foot Diseases / veterinary
          • Hoof and Claw / pathology
          • Horse Diseases / pathology
          • Horses
          • Male

          Citations

          This article has been cited 6 times.
          1. Akinniyi OO, Sackey AKB, Ochube GE, Mshelia PW, Musa FA, Elijah MO, Jolayemi KO. Occurrence of equine metabolic syndrome, clinical manifestations, and associated risk factors in Nigeria. J Equine Sci 2023 Jun;34(2):29-35.
            doi: 10.1294/jes.34.29pubmed: 37405068google scholar: lookup
          2. Sundberg JP, Galantino-Homer H, Fairfield H, Ward-Bailey PF, Harris BS, Berry M, Pratt CH, Gott NE, Bechtold LS, Kaplan PR, Durbin-Johnson BP, Rocke DM, Rice RH. Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. PLoS One 2022;17(11):e0277284.
            doi: 10.1371/journal.pone.0277284pubmed: 36374931google scholar: lookup
          3. Sato F, Otsuka N, Kuwano A. Toe white line separation associated with the notch (crena marginalis) on the distal phalanges in Thoroughbred yearling horses. J Vet Med Sci 2021 Nov 16;83(11):1745-1749.
            doi: 10.1292/jvms.21-0270pubmed: 34556604google scholar: lookup
          4. Cassimeris L, Engiles JB, Galantino-Homer H. Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis. PLoS One 2020;15(12):e0232920.
            doi: 10.1371/journal.pone.0232920pubmed: 33301461google scholar: lookup
          5. Cassimeris L, Engiles JB, Galantino-Homer H. Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis. BMC Vet Res 2019 Jan 10;15(1):24.
            doi: 10.1186/s12917-018-1748-xpubmed: 30630474google scholar: lookup
          6. Kuwano A, Hasegawa T, Arai K. Type VII and XVII Collagen mRNA Expressions in Regenerated Epidermal Laminae in Chronic Equine Laminitis. J Equine Sci 2008;19(4):103-7.
            doi: 10.1294/jes.19.103pubmed: 24833961google scholar: lookup