A gross and histopathological study of an ectopic white line development in equine laminitis.
- Journal Article
Summary
The research article is an investigation into an abnormal hoof structure that develops in horses suffering from chronic laminitis. The study provides insights into the morphology and development of this structure, termed an ‘ectopic white line’.
Article Explanation and Research Overview
The research paper is a detailed study on the anomaly noticed in the hoof of horses suffering from chronic laminitis, a disease characterized by inflammation of the sensitive layers of tissue beneath the hard outer shell of the horse’s hoof. The abnormality is referred to as the ‘lamellar wedge’, an abnormal horny structure that develops between the hoof wall and the laminar epidermis.
- The main objective of the study was to gather and scrutinize morphological data of this abnormal structure to better understand its formation and growth.
- This investigation is important as it provides information necessary to improve management and treatment of equine chronic laminitis.
Research Methodology and Findings
The research conducted a gross and histopathological examination of the hoof anomaly.
- It was observed that the abnormal horn becomes visible on the sagittal hoof section approximately after 20 days from the onset of the disease.
- Through histological observations, the structural characteristics of the abnormal horn were found to be similar to white line tissue, thereby classifying it as an ‘ectopic white line’.
- In the aberrant horn, the cross-sectional area against the distal phalanx section area (A/D) had a mean value of 0.29 cm2, a significant increase from the average value in a normal hoof.
Conclusion and Implications
The study concluded that the ectopic white line contributes significantly to inhibiting normal hoof wall growth.
- This finding suggests that the abnormal structure should be removed at an optimal time to prevent further impairment of the hoof’s normal growth, ideally after a month from the onset of the disease.
- The insights from the study are critical in aiding the treatment and management of horses suffering from chronic laminitis, enhancing prospects of their recovery and wellbeing.
Cite This Article
Publication
Researcher Affiliations
- Clinical Science & Pathobiology Division, Equine Research Institute, Japan Racing Association, Utsunomiya-shi, Tochigi, Japan.
MeSH Terms
- Animals
- Female
- Foot Diseases / pathology
- Foot Diseases / veterinary
- Hoof and Claw / pathology
- Horse Diseases / pathology
- Horses
- Male
Citations
This article has been cited 6 times.- Akinniyi OO, Sackey AKB, Ochube GE, Mshelia PW, Musa FA, Elijah MO, Jolayemi KO. Occurrence of equine metabolic syndrome, clinical manifestations, and associated risk factors in Nigeria. J Equine Sci 2023 Jun;34(2):29-35.
- Sundberg JP, Galantino-Homer H, Fairfield H, Ward-Bailey PF, Harris BS, Berry M, Pratt CH, Gott NE, Bechtold LS, Kaplan PR, Durbin-Johnson BP, Rocke DM, Rice RH. Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. PLoS One 2022;17(11):e0277284.
- Sato F, Otsuka N, Kuwano A. Toe white line separation associated with the notch (crena marginalis) on the distal phalanges in Thoroughbred yearling horses. J Vet Med Sci 2021 Nov 16;83(11):1745-1749.
- Cassimeris L, Engiles JB, Galantino-Homer H. Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis. PLoS One 2020;15(12):e0232920.
- Cassimeris L, Engiles JB, Galantino-Homer H. Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis. BMC Vet Res 2019 Jan 10;15(1):24.
- Kuwano A, Hasegawa T, Arai K. Type VII and XVII Collagen mRNA Expressions in Regenerated Epidermal Laminae in Chronic Equine Laminitis. J Equine Sci 2008;19(4):103-7.