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TheScientificWorldJournal2013; 2013; 349702; doi: 10.1155/2013/349702

A multigene approach for comparing genealogy of Betacoronavirus from cattle and horses.

Abstract: Gastroenteritis is one of the leading causes of morbidity and mortality among young and newborn animals and is often caused by multiple intestinal infections, with rotavirus and bovine coronavirus (BCoV) being the main viral causes in cattle. Given that BCoV is better studied than equine coronaviruses and given the possibility of interspecies transmission of these viruses, this research was designed to compare the partial sequences of the spike glycoprotein (S), hemagglutinin-esterase protein (HE), and nucleoprotein (N) genes from coronaviruses from adult cattle with winter dysentery, calves with neonatal diarrhea, and horses. To achieve this, eleven fecal samples from dairy cows with winter dysentery, three from calves, and two from horses, all from Brazil, were analysed. It could be concluded that the enteric BCoV genealogy from newborn and adult cattle is directly associated with geographic distribution patterns, when S and HE genes are taken into account. A less-resolved genealogy exists for the HE and N genes in cattle, with a trend for an age-related segregation pattern. The coronavirus strains from horses revealed Betacoronavirus sequences indistinguishable from those found in cattle, a fact previously unknown.
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Publication Date: 2013-11-17 PubMed ID: 24348152PubMed Central: PMC3855977DOI: 10.1155/2013/349702Google Scholar: Lookup
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  • Journal Article
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article analysed the gene sequences of coronaviruses found in cattle and horses. The study suggests that transmission of these viruses may occur between the two species, indicating a need for further understanding and prevention measures.

Research Objective and Method

  • The primary aim of this research was to study and compare the gene sequences of coronaviruses prevalent in cattle and horses. This objective was driven by the necessity to understand potential interspecies transmission—a phenomenon where a pathogen jumps from one species to another.
  • The researchers analyzed three partial gene sequences—spike glycoprotein (S), hemagglutinin-esterase protein (HE), and nucleoprotein (N)—in coronaviruses from adult cattle with winter dysentery, calves with neonatal diarrhea, and horses. These samples were all sourced from Brazil.
  • The team utilized a multi gene approach to present a comprehensive view of the virus’s behavior and evolution in both species.

Key Findings

  • Through this multi gene analysis, the researchers found that the coronaviruses’ genealogy or gene sequences in newborn and adult cattle were strongly linked to geographical distribution patterns. This was especially true when the S and HE genes were considered.
  • However, a more convoluted genealogy was discovered for the HE and N genes in cattle. Rather than a strict adherence to geographical distribution, these genes seemed to display an age-related segregation pattern.
  • What was particularly striking about the research was the discovery that the strains of coronaviruses found in horses revealed gene sequences, specifically Betacoronaviruses, which were nearly indistinguishable from those found in cattle.

Implications and Conclusions

  • This discovery presented a previously unknown aspect of coronavirus genealogy—that they may be transmitted interspecies, particularly between cattle and horses.
  • This finding suggests a need to study further the mechanisms of interspecies transmission and develop ways of monitoring and preventing this from happening. It could have significant implications for viral disease resilience in livestock populations.

Cite This Article

APA
Barros IN, Silva SO, Nogueira Neto FS, Asano KM, Souza SP, Richtzenhain LJ, Brandao PE. (2013). A multigene approach for comparing genealogy of Betacoronavirus from cattle and horses. ScientificWorldJournal, 2013, 349702. https://doi.org/10.1155/2013/349702

Publication

TheScientificWorldJournal
ISSN: 1537-744X
NlmUniqueID: 101131163
Country: United States
Language: English
Volume: 2013
Pages: 349702
PII: 349702

Researcher Affiliations

Barros, Iracema N
  • Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil ; Coronavirus Research Group, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil.
Silva, Sheila O S
  • Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil ; Coronavirus Research Group, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil.
Nogueira Neto, Francisco S
  • Jockey Club of São Paulo, Bento Frias Street 248, Group 555, 05423-050 São Paulo, SP, Brazil.
Asano, Karen M
  • Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil ; Coronavirus Research Group, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil.
Souza, Sibele P
  • Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil ; Coronavirus Research Group, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil.
Richtzenhain, Leonardo J
  • Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil ; Coronavirus Research Group, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil.
Brandao, Paulo E
  • Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil ; Coronavirus Research Group, College of Veterinary Medicine, University of São Paulo, Avenue Professor Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil.

MeSH Terms

  • Animals
  • Brazil
  • Cattle
  • Coronavirus, Bovine / classification
  • Coronavirus, Bovine / genetics
  • Genes, Viral
  • Geography
  • Horses
  • Phylogeny

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Citations

This article has been cited 5 times.
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