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Asian journal of neurosurgery2016; 11(3); 201-205; doi: 10.4103/1793-5482.179645

A novel equine-derived pericardium membrane for dural repair: A preliminary, short-term investigation.

Abstract: A large variety of biological and artificial materials are employed in dural repair, each of them with major limitations. Autologous grafts have limited availability and require an additional incision and surgical time. Cadaveric preparations and heterologous materials entail the risk of iatrogenic transmission of prions, whereas synthetic substitutes have been reported to cause inflammatory reactions and graft rejection. An equine-derived pericardium membrane has been developed (Heart(®), Bioteck, Vicenza, Italy) with mechanical and safety-related features that could make it suitable for neurosurgical application. Objective: This preliminary study aimed to evaluate the short-term safety and efficacy of the Heart(®) membrane in dural repair procedures following meningioma surgeries. Methods: Medical records of patients who were surgically treated for an intracranial meningioma and underwent duraplasty with the Heart(®) membrane were reviewed retrospectively. The occurrence of any graft-related complications such as cerebrospinal fluid (CSF) leakage, postoperative hematoma, wound infection, meningitis, and neurological symptoms was analyzed. Results: Eight patients were identified as meeting the inclusion criteria. A watertight closure was achieved in all of them. Postoperatively, no patients exhibited CSF leak, cerebral contusion, hemorrhage, or wound infection. The 1-month radiological follow-up revealed no evidence of pseudomeningocele, wound breakdown, or meningitis. Neurologic complications were observed in three patients but not directly imputable to the dural substitute or its application. Conclusions: In all the patients, the pericardium membrane enabled achievement of a watertight dural closure without graft-related adverse events. Further investigations should be performed to assess medium- and long-term clinical outcomes in a larger set of patients.
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Publication Date: 2016-07-02 PubMed ID: 27366245PubMed Central: PMC4849287DOI: 10.4103/1793-5482.179645Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines and reports the short-term safety and efficacy of a novel equine-derived pericardium membrane, Heart®, for dural repair in patients undergoing meningioma surgeries. No adverse events were related to the use of the membrane, which successfully enabled watertight dural closure in all cases.

Study Objective

  • The research aimed to evaluate the short-term safety and effectiveness of a new equine-derived pericardium membrane known as Heart®. This membrane was used in duraplasty procedures following surgeries to remove intracranial meningioma, a type of brain tumor.

Methods Used in the Study

  • The researchers retrospectively reviewed medical records of patients who had been surgically treated for an intracranial meningioma and who had opted for duraplasty with the Heart® membrane.
  • They specifically analyzed the occurrence of any graft-related complications like cerebrospinal fluid (CSF) leakage, postoperative hematoma, wound infection, meningitis, and neurological symptoms.

Study Results

  • The study found that eight patients met the inclusion criteria, displaying a watertight closure in all cases.
  • Post-surgery, none of these patients exhibited complications such as CSF leak, cerebral contusion, hemorrhage, or wound infection.
  • One-month radiological follow-ups showed no evidence of further complications like pseudomeningocele, wound breakdown, or meningitis.
  • While three patients did exhibit neurological complications, these issues were not directly linked to the use of the Heart® membrane or its application in duraplasty.

Conclusions from the Study

  • These preliminary findings suggest that the novel pericardium membrane enables a watertight dural closure without leading to any graft-related adverse events.
  • The researchers propose developing further investigations to assess the medium and long-term clinical outcomes in a larger set of patients, strengthening the validity of these initial findings.

Cite This Article

APA
Centonze R, Agostini E, Massaccesi S, Toninelli S, Morabito L. (2016). A novel equine-derived pericardium membrane for dural repair: A preliminary, short-term investigation. Asian J Neurosurg, 11(3), 201-205. https://doi.org/10.4103/1793-5482.179645

Publication

Asian journal of neurosurgery
ISSN: 1793-5482
NlmUniqueID: 101564712
Country: India
Language: English
Volume: 11
Issue: 3
Pages: 201-205

Researcher Affiliations

Centonze, Roberto
  • Division of Neurosurgery, Ospedali Riuniti Marche Nord Hospital, Pesaro, Italy.
Agostini, Emiliano
  • Division of Neurosurgery, Ospedali Riuniti Marche Nord Hospital, Pesaro, Italy.
Massaccesi, Samantha
  • Division of Neurosurgery, Ospedali Riuniti Marche Nord Hospital, Pesaro, Italy.
Toninelli, Stefano
  • Division of Neurosurgery, Ospedali Riuniti Marche Nord Hospital, Pesaro, Italy.
Morabito, Letterio
  • Division of Neurosurgery, Ospedali Riuniti Marche Nord Hospital, Pesaro, Italy.

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This article has been cited 8 times.
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