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Journal of the American Veterinary Medical Association2023; 261(2); 153-164; doi: 10.2460/javma.22.11.0485

A one-health lens offers new perspectives on the importance of endocrine disorders in the equine athlete.

Abstract: Endocrine disorders are associated with joint pain and tendon injury in humans, but the effects in the horse are only starting to be understood. Similar patterns of clinical signs and injury appear to affect horses and humans for both orthopedic and endocrine disorders, supporting the use of a one-health approach to tackle these issues. In this Currents in One Health, we will discuss common equine endocrinopathies, current testing recommendations, dietary management, genetic predispositions, and endocrine disorders' effects on performance. Our aim is to use a one-health lens to describe current comparative research so that veterinarians can employ cutting-edge preventative, diagnostic, and therapeutic recommendations. Identified key gaps in knowledge include whether equine metabolic osteoarthritis exists, if steroid joint injections are safe in horses with endocrine disorders, and if the return to performance percentage improves with concurrent treatment of endocrine and musculoskeletal disorders. Key takeaways include that the relationship between endocrine disorders and musculoskeletal disease in the horse goes beyond laminitis to include lameness, muscle atrophy, suspensory ligament degeneration, osteochondritis dissecans, and potentially metabolic osteoarthritis. Approaches learned from human and equine comparative studies can offer insight into injury recognition and management, thus mitigating the impact of endocrine disorders on performance in both species. Readers interested in an in-depth description of current and future research involving pathophysiology, novel interventions, and multiomic approaches to identify individuals with athletic limitations induced by endocrine disorders are invited to read the companion Currents in One Health by Manfredi et al, AJVR, February 2023.
Publication Date: 2023-01-02 PubMed ID: 36595370DOI: 10.2460/javma.22.11.0485Google Scholar: Lookup
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Summary

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The research discusses the association between endocrine disorders and orthopedic injuries in equine athletes and suggests a one-health approach for better understanding and treatment. With this approach, the study explores common equine endocrine disorders, the role of diet, genetic factors, and their impact on performance.

Understanding Endocrine Disorders in Equine Athletes

  • The research discusses the impact of endocrine disorders on athletic horses, observing that these disorders trigger joint pain and tendon injuries, similar to humans. However, the research indicates that understanding these impacts on horses is still in primary stages.
  • This article also explores the potential correlations between orthopedic and endocrine ailments in horses, emphasizing a cross-species, one-health approach for studying these health issues.
  • The research delves into common endocrine disorders in equines, diagnostic tests currently being used, and the role of a horse’s diet in managing these conditions. Furthermore, the authors review the genetic variables that can predispose a horse to endocrine problems.

The Effect on Performance and Identified Knowledge gaps

  • The authors illuminate how these endocrine disorders affect an equine athlete’s performance. It addresses some of the critical knowledge gaps in comprehending the relationship between these disorders and musculoskeletal diseases in horses. For instance, the paper raises questions about the existence of metabolic osteoarthritis in horses, the safety of steroid joint injections for horses with endocrine disorders, and whether the rate of returning to performance improves by concurrently treating endocrine and skeletal disorders.

Implications of the Research and Key Takeaways

  • One of the main conclusions the authors draw from their analysis is that endocrine disorders’ effects on musculoskeletal health in horses extend beyond laminitis, affecting features such as lameness, muscle atrophy, and degeneration of the suspensory ligament, among others.
  • The paper also suggests that insights gleaned from comparative studies between humans and equines could enhance injury recognition and management, thereby diminishing endocrine disorders’ influence on performance across species.
  • The research encourages an in-depth understanding of current and future research on pathophysiology, novel interventions, and multiomic strategies for identifying individuals with athletic limitations caused by endocrine disorders.

Cite This Article

APA
Manfredi JM, Jacob S, Norton E. (2023). A one-health lens offers new perspectives on the importance of endocrine disorders in the equine athlete. J Am Vet Med Assoc, 261(2), 153-164. https://doi.org/10.2460/javma.22.11.0485

Publication

ISSN: 1943-569X
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 261
Issue: 2
Pages: 153-164

Researcher Affiliations

Manfredi, Jane M
  • 1Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI.
Jacob, Sarah
  • 1Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI.
Norton, Elaine
  • 2Department of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ.

MeSH Terms

  • Humans
  • Horses
  • Animals
  • One Health
  • Sports
  • Athletes
  • Osteoarthritis / therapy
  • Osteoarthritis / veterinary
  • Horse Diseases / diagnosis

Citations

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