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Veterinary ophthalmology2022; 26(2); 86-100; doi: 10.1111/vop.13002

A review of investigated risk factors for developing equine recurrent uveitis.

Abstract: Equine recurrent uveitis (ERU) is an ocular inflammatory disease that can be difficult to manage clinically. As such, it is the leading cause of bilateral blindness for horses. ERU is suspected to have a complex autoimmune etiology with both environmental and genetic risk factors contributing to onset and disease progression in some or all cases. Work in recent years has aimed at unraveling the primary triggers, such as infectious agents and inherited breed-specific risk factors, for disease onset, persistence, and progression. This review has aimed at encompassing those factors that have been associated, implicated, or substantiated as contributors to ERU, as well as identifying areas for which additional knowledge is needed to better understand risk for disease onset and progression. A greater understanding of the risk factors for ERU will enable earlier detection and better prognosis through prevention and new therapeutics.
© 2022 American College of Veterinary Ophthalmologists.
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Publication Date: 2022-06-12 PubMed ID: 35691017DOI: 10.1111/vop.13002Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper provides a comprehensive review of the risk factors associated with equine recurrent uveitis (ERU), a leading cause of blindness in horses, and identifies areas where more knowledge is needed for better prognosis through prevention and treatment.

About Equine Recurrent Uveitis

  • Equine recurrent uveitis (ERU) is an inflammatory disease of the eye, which is difficult to manage clinically due to its repetitive nature.
  • It is the primary cause of bilateral blindness in horses, meaning it affects both eyes, leading to complete loss of vision.
  • The disease is thought to have a complex autoimmune etiology – the onset and progression of the disease is influenced by a combination of genetic and environmental risk factors.

Understanding the Risk Factors

  • The article reviews the various factors that have been associated with ERU. This includes primary triggers such as infectious agents and inherited breed-specific risk factors.
  • Understanding these risk factors can help in early detection of the disease and also in designing prevention strategies and therapeutics.
  • The study also points out that the understanding of these risk factors is not complete and further research is necessary.

Significance of the Study

  • This review of risk factors is crucial because it compiles and analyses existing data on ERU. This can serve as a useful resource for future research in this field.
  • The study identifies gaps in our understanding of ERU, suggesting areas that need further investigation. This could potentially lead to breakthroughs in prevention and treatment methods.
  • A better understanding of the risk factors associated with ERU can help develop better strategies for early diagnosis, treatment, and management of the disease, thus improving the overall prognosis for affected horses.

Cite This Article

APA
Kingsley NB, Sandmeyer L, Bellone RR. (2022). A review of investigated risk factors for developing equine recurrent uveitis. Vet Ophthalmol, 26(2), 86-100. https://doi.org/10.1111/vop.13002

Publication

Veterinary ophthalmology
ISSN: 1463-5224
NlmUniqueID: 100887377
Country: England
Language: English
Volume: 26
Issue: 2
Pages: 86-100

Researcher Affiliations

Kingsley, Nicole B
  • Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California - Davis, Davis, California, USA.
  • Department of Population Health and Reproduction, School of Veterinary Medicine, University of California - Davis, Davis, California, USA.
Sandmeyer, Lynne
  • Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Bellone, Rebecca R
  • Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California - Davis, Davis, California, USA.
  • Department of Population Health and Reproduction, School of Veterinary Medicine, University of California - Davis, Davis, California, USA.

MeSH Terms

  • Horses
  • Animals
  • Horse Diseases / etiology
  • Uveitis / veterinary
  • Eye
  • Prognosis
  • Risk Factors

Grant Funding

  • D16EQ-028 / Morris Animal Foundation
  • Townsend Equine Health Research Fund
  • 18-17 / University of California Davis, Center for Equine Health

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