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Home / Equine Research Bank / Can Vet J / A review of the pharmacology and clinical uses of ivermectin...
The Canadian veterinary journal = La revue veterinaire canadienne1987; 28(8); 512-517;

A review of the pharmacology and clinical uses of ivermectin.

Abstract: The avermectins were introduced in 1981 and constitute a potent new class of anthelmintic agents. They are naturally-derived products of microbial action displaying an exceptionally wide range of antiparasitic efficacy against internal and external parasites of domestic animals. This paper reviews their isolation and chemistry, mechanism of action, chemical efficacy and safety in cattle, sheep, swine, horses and dogs.
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Publication Date: 1987-08-01 PubMed ID: 17422843PubMed Central: PMC1680605
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article offers a comprehensive review of avermectins, specifically ivermectin, a class of anthelmintic (anti-parasitic) agents introduced in 1981. It examines the compound’s origins, chemistry, mechanism of action, and its efficacy and safety in treating internal and external parasites in various domestic animals.

Isolation and Chemistry of Avermectins

  • The avermectins are a family of medications that are produced by a process of microbial fermentation. They bear potent anthelmintic properties which makes them effective against a broad spectrum of internal and external parasites.
  • Ivermectin, a member of the avermectins group, offers notable efficacy against various parasites and has been widely used in the veterinary field.

Mechanism of Action

  • The paper explores how avermectins, particularly ivermectin, function as anthelmintic agents. These drugs typically work by inhibiting the nervous system of the targeted parasites, causing their paralysis or death.
  • By examining the mechanism of action, the researchers sought to gain a deeper understanding of the ways in which these compounds affect different species of parasites and can be used as effective treatments.

Chemical Efficacy

  • The efficacy of avermectins is discussed in detail, highlighting how their chemical structure allows them to successfully combat various species of parasites.
  • Through experiments and practical application, avermectins have been found to be highly effective in dealing with a wide range of parasites that infest domestic animals.

Safety in Animals

  • The paper further evaluates the safety of using avermectins, like ivermectin, as treatments for cattle, sheep, swine, horses, and dogs. Detailed analyses of the potential risks, side effects, and adverse reactions are provided to ensure the optimal usage of these drugs.
  • The extensive exploration of safety contributes to the research community’s comprehensive understanding of avermectins’ benefits and risks, thus allowing for safer and more tailored use of these agents in veterinary medicine.

Cite This Article

APA
Barragry TB. (1987). A review of the pharmacology and clinical uses of ivermectin. Can Vet J, 28(8), 512-517.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 28
Issue: 8
Pages: 512-517

Researcher Affiliations

Barragry, T B

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