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Home / Equine Research Bank / Animals (Basel) / A Saccharomyces cerevisiae Fermentation Product (Olimond BB)...
Animals : an open access journal from MDPI2021; 11(9); 2726; doi: 10.3390/ani11092726

A Saccharomyces cerevisiae Fermentation Product (Olimond BB) Alters the Early Response after Influenza Vaccination in Racehorses.

Abstract: () fermentation products (SCFP) are used in animal husbandry as pre- and postbiotic feed supplements. A variety of immunomodulatory effects are noted in many species. The purpose of this study was to test the hypothesis that horses fed with SCFP containing feed additive Olimond BB display a modulated early immune response after influenza vaccination. Six horses received Olimond BB pellets (OLI) and five horses were fed placebo pellets (PLA) for 56 days. On day 40 all horses were vaccinated with a recombinant influenza A/equi-2 vaccine. At the day of vaccination, the groups did not differ in the composition of leukocyte subpopulations and reticulocytes. Twenty-four hours after vaccination total leukocyte counts and numbers of CD4 T-cells significantly increased in both groups. In PLA horses, the numbers of neutrophil granulocytes significantly increased and numbers of CD8 T-cells decreased, whereas the numbers of these cell types remained unchanged in OLI horses. Only OLI horses displayed a significant increase in reticulocyte percentages after vaccination. The numbers of lymphocytes, monocytes, CD21 B-cells, and serum amyloid A levels remained unaffected in both groups after vaccination. Sixteen days after vaccination, PLA and OLI horses differed significantly in their enhanced ELISA IgG titres against Newmarket and Florida Clade 1 influenza strains. The observed differences after vaccination suggest that feed supplementation with Olimond BB leads to modulated early immune responses after influenza vaccination, which may also affect the memory responses after booster vaccination.
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Publication Date: 2021-09-18 PubMed ID: 34573692PubMed Central: PMC8466050DOI: 10.3390/ani11092726Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates the influence of a particular yeast fermentation product, Olimond BB, on the early immune responses of racehorses post-influenza vaccination.

Objective of the Research

  • This study aims to test the hypothesis that incorporating a Saccharomyces cerevisiae Fermentation Product (SCFP) known as Olimond BB in horse feed may modulate the early immune response following influenza vaccination.

Methodology & Experiment

  • Eleven horses participated in the experiment. Six horses were given feed supplemented with Olimond BB pellets (OLI group) and five horses were given placebo pellets (PLA group). The experiment lasted for 56 days.
  • All the horses, regardless of their group, were inoculated with a recombinant influenza A/equi-2 vaccine on the 40th day of the experiment.
  • The researchers monitored and recorded changes in the composition of leukocyte subpopulations, reticulocytes, and various cell types in the blood of the horses.

Results

  • At the time of vaccination, the groups showed no differences in leukocyte subpopulations and reticulocyte composition. Post-vaccination, both groups displayed a significant increase in total leukocyte counts and CD4 T-cell numbers.
  • In the PLA group, the researchers observed a significant increase in neutrophil granulocytes and a decrease in the number of CD8 T-cells. However, these cell types remained unchanged in the OLI group.
  • Only the OLI group exhibited a significant increase in reticulocyte percentages after vaccination.
  • The count of lymphocytes, monocytes, CD21 B-cells, and levels of serum amyloid A remained stable in both groups post-vaccination.
  • By the 16th day post-vaccination, the PLA and OLI groups showed significant differences in their enhanced ELISA IgG titres against Newmarket and Florida Clade 1 influenza strains.

Conclusion

  • The researchers concluded that supplementation of horse feed with Olimond BB leads to perceptible changes in early immune responses post-influenza vaccination. This could potentially suggest that Olimond BB may also influence memory responses after a booster vaccination.

Cite This Article

APA
Lucassen A, Finkler-Schade C, Schuberth HJ. (2021). A Saccharomyces cerevisiae Fermentation Product (Olimond BB) Alters the Early Response after Influenza Vaccination in Racehorses. Animals (Basel), 11(9), 2726. https://doi.org/10.3390/ani11092726

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 9
PII: 2726

Researcher Affiliations

Lucassen, Alexandra
  • Institute of Immunology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.
Finkler-Schade, Christa
  • Schade & Partner, 27283 Verden, Germany.
Schuberth, Hans-Joachim
  • Institute of Immunology, University of Veterinary Medicine Foundation, 30559 Hannover, Germany.

Grant Funding

  • no grant mumber / BB horses GmbH&Co.KG

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 7 times.
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