A single subcutaneous administration of buserelin induces ovulation in the mare: field data.
Abstract: The aim of the present study, was to evaluate whether a single subcutaneous administration of the GnRH analogue buserelin could induce ovulation in the mare during the breeding season. Two studies were carried out under field conditions. In Experiment 1, 90 cycles of trotter mares aged 2-7 years, were assigned to a buserelin group (Bus1) or to a control group (Control), in the presence of a >/=35 mm pre-ovulatory follicle, with uterine oedema and a relaxed cervix. Ten mares were assigned to the two groups for 32 cycles in Bus1 and 52 cycles in Control, two mares received only Bus1 for three cycles, and one mare was assigned to Control for three cycles. Mares treated with buserelin received 6 ml of SUPREFACT s.c. (1.05 mg/ml buserelin acetate), and no treatment was given in Control. The ovulation rate between 24 and 48 h was higher (p < 0.0001) in Bus1 (31/35) than in Control (15/55). In Experiment 2, the condition of inducing ovulation with 6 ml SUPREFACT s.c. (Bus2) or 1500 ui human chorionic gonadotropin were identical to the first study. Forty-nine mares of ages 2-21 years, were used for 120 cycles, 56 cycles were assigned to Bus2, and 64 cycles were induced with 1500 IU human chorionic gonadotropin i.v. No significant difference was found in the ovulation rate on day 2 (38/56, 50/64), or in the fertility rate (19/48, 26/57). No negative effect of the treatment was observed with repeated buserelin administration in either study during the breeding season. We can conclude that a single administration of buserelin induces ovulation in the mare, under suitable conditions for veterinary practitioners.
Publication Date: 2007-09-12 PubMed ID: 17845612DOI: 10.1111/j.1439-0531.2006.00822.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research aimed to investigate if a single subcutaneous dose of GnRH analogue buserelin could induce ovulation in mares during breeding season. The research found that administering buserelin did induce ovulation in mares, without negatively affecting them, if administered under the right conditions.
Objective of the Research
The primary purpose of this study was to find out whether a single subcutaneous administration of the GnRH analogue buserelin could induce ovulation in mares during their breeding season.
- The researchers conducted two different experiments under normal field conditions, with mares of varying ages, to test the effectiveness of buserelin in inducing ovulation.
- Different hormonal treatments were used as controls to compare the ovulation rate and fertility rate with the buserelin-treated mares.
Research Methodology
The study spanned two field-based experiments involving varying cycles of mares, in which different treatment methods were used:
- Experiment 1 involved dividing 90 cycles of trotter mares aged 2-7 years into two groups: one group was administered buserelin (Bus1) and the other was a non-treated control group. These mares had a pre-ovulatory follicle of >/=35mm, uterine oedema, and a relaxed cervix.
- Experiment 2, similar to Experiment 1, used buserelin (Bus2) and compared it against human chorionic gonadotropin for treating 120 cycles of mares aged 2-21 years. The purpose was to compare the ovulation and fertility rates of both treatments.
Findings of the Research
The results of the two experiments indicated that a single administration of buserelin can effectively induce ovulation in mares without negative consequences.
- The ovulation rate between 24 and 48 hours post-treatment was significantly higher for mares treated with buserelin compared to the control group in the first experiment.
- In the second experiment, the ovulation and fertility rates for mares treated with buserelin did not significantly differ from those treated with human chorionic gonadotropin.
- No negative effects were observed from repeated buserelin administration in mares throughout the breeding season, in both experiments.
Conclusion of the Research
Based on the positive ovulation rates seen in this study, a single administration of buserelin acutely induces ovulation in mares during the breeding season under suitable conditions. No adverse effects were noted from the treatment, making buserelin a potential choice for veterinary practitioners.
Cite This Article
APA
Levy I, Duchamp G.
(2007).
A single subcutaneous administration of buserelin induces ovulation in the mare: field data.
Reprod Domest Anim, 42(5), 550-554.
https://doi.org/10.1111/j.1439-0531.2006.00822.x Publication
Researcher Affiliations
- DVM, la Nouvetiere, Sonzay, France.
MeSH Terms
- Animals
- Breeding / methods
- Buserelin / pharmacology
- Drug Administration Schedule
- Female
- Fertility Agents, Female / pharmacology
- Horses / physiology
- Injections, Subcutaneous / veterinary
- Ovulation Induction / methods
- Ovulation Induction / veterinary
- Pregnancy
- Pregnancy Rate
- Time Factors
Citations
This article has been cited 2 times.- Bottrel M, Ortiz I, Hidalgo M, Díaz-Jiménez M, Pereira B, Consuegra C, Yousef MS, Dorado J. Hormonal Management for the Induction of Luteolysis and Ovulation in Andalusian Jennies: Effect on Reproductive Performance, Embryo Quality and Recovery Rate. Animals (Basel) 2022 Jan 8;12(2).
- Fanelli D, Tesi M, Rota A, Beltramo M, Conte G, Giorgi M, Barsotti G, Camillo F, Panzani D. hCG is more effective than the GnRH agonist buserelin for inducing the first ovulation of the breeding season in mares. Equine Vet J 2022 Mar;54(2):306-311.
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