FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / J Vet Med Sci / A study regarding bovine enterovirus type 1 infection in dom...
The Journal of veterinary medical science2019; 81(12); 1824-1828; doi: 10.1292/jvms.18-0704

A study regarding bovine enterovirus type 1 infection in domestic animals and humans: An evaluation from the zoonotic aspect.

Abstract: Bovine enteroviruses (BEV) are members of Enterovirus genus of the family Picornaviridae. BEV1 has a broad host spectrum, including humans. The virus usually causes subclinical infection, but fatal/severe cases have also been reported in different animal species. There is quite limited data regarding BEV1 in humans. The purpose of this study is to investigate human infection and to identify possible risk factors for viral exposure. For this purpose, blood serum samples (n=1,526) were collected from a city center and nearby villagers simultaneously from humans and farm animals in Elazig province in Eastern Anatolia. As a result of serum neutralisation test, BEV1 specific antibody presence detected in cattle was 85.3% (163/191), 73.5% in donkeys (64/87), 71.8% in goats (115/160), 46.5% in sheep (93/200), 43.9% in horses (40/91), 41.3% in dogs (19/46) and 33% in humans (248/751). Although a high contamination potential was mentioned for people living in rural areas, it was determined that infection rates in rural areas (31.6%) and urban centers (32.2%) were very close. There was no difference according to sex. Viral exposure is higher in the 40 to 70 age range. In addition, the serological evidence of the infection in donkeys was identified for the first time with this study.
Get Full Text
Publication Date: 2019-09-27 PubMed ID: 31564680PubMed Central: PMC6943316DOI: 10.1292/jvms.18-0704Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study investigates the spread and risk factors of Bovine Enterovirus type 1 (BEV1), a virus found in domestic animals, amongst humans. Concern was raised due to limited data about its impact on human health.

Subjects and Study Design

  • The researchers collected blood serum samples from 1,526 human and animal subjects.
  • These subjects were from Elazig province in Eastern Anatolia, living either in the city center or in nearby villages.

Results of Serum Neutralisation Test

  • The serum neutralisation test was utilised to detect the presence of BEV1 antibodies in the blood of the subjects.
  • Among diverse species, the prevalence of BEV1 was highest in cattle (85.3%), followed by donkeys (73.5%), goats (71.8%), sheep (46.5%), horses (43.9%), dogs (41.3%), and lastly humans (33%).

Infection Rates in Urban and Rural Areas

  • Analyses from the study depicted that infection rates were quite similar between rural and urban communities, being 31.6% and 32.2% respectively.
  • These findings debunked the belief that people living in rural areas are at higher risk of BEV1 infection.

Infection Rates Based on Sex and Age Group

  • Investigation on the sex-wise distribution of viral exposure declared no significant difference between males and females.
  • However, age-wise analysis determined a higher exposure to the virus in the age group of 40 to 70 years.

New Findings

  • This study marked a significant milestone by being the first to supply serological evidence of BEV1 infection in donkeys.

Cite This Article

APA
Gür S, Gürçay M, Seyrek A. (2019). A study regarding bovine enterovirus type 1 infection in domestic animals and humans: An evaluation from the zoonotic aspect. J Vet Med Sci, 81(12), 1824-1828. https://doi.org/10.1292/jvms.18-0704

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 81
Issue: 12
Pages: 1824-1828

Researcher Affiliations

Gür, Sibel
  • Department of Virology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar 03200, Turkey.
Gürçay, Metin
  • Department of Virology, Faculty of Veterinary Medicine, Bingöl University, Bingöl 12000, Turkey.
Seyrek, Adnan
  • Department of Microbiology, Faculty of Medicine, Fırat University, Elazığ 23119, Turkey.

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Antibodies, Viral / blood
  • Child
  • Child, Preschool
  • Dogs / virology
  • Enterovirus Infections / epidemiology
  • Enterovirus Infections / veterinary
  • Enterovirus, Bovine / immunology
  • Enterovirus, Bovine / isolation & purification
  • Female
  • Humans
  • Infant
  • Livestock / virology
  • Male
  • Middle Aged
  • Turkey / epidemiology
  • Zoonoses / epidemiology

Conflict of Interest Statement

The authors declare no conflicts of interest.

References

This article includes 35 references
  1. Acar A, Gür S. Sroprevalance of bovine enterovirus 1 (BEV1) in goats in Turkey.. J. Anim. Vet. Adv. 8: 1075–1078.
  2. Blas-Machado U, Saliki JT, Boileau MJ, Goens SD, Caseltine SL, Duffy JC, Welsh RD. Fatal ulcerative and hemorrhagic typhlocolitis in a pregnant heifer associated with natural bovine enterovirus type-1 infection.. Vet Pathol 2007 Jan;44(1):110-5.
    doi: 10.1354/vp.44-1-110pubmed: 17197635google scholar: lookup
  3. Chapron CD, Ballester NA, Fontaine JH, Frades CN, Margolin AB. Detection of astroviruses, enteroviruses, and adenovirus types 40 and 41 in surface waters collected and evaluated by the information collection rule and an integrated cell culture-nested PCR procedure.. Appl Environ Microbiol 2000 Jun;66(6):2520-5.
    doi: 10.1128/AEM.66.6.2520-2525.2000pmc: PMC110573pubmed: 10831432google scholar: lookup
  4. Corsi SR, Borchardt MA, Spencer SK, Hughes PE, Baldwin AK. Human and bovine viruses in the Milwaukee River watershed: hydrologically relevant representation and relations with environmental variables.. Sci Total Environ 2014 Aug 15;490:849-60.
    doi: 10.1016/j.scitotenv.2014.05.072pmc: PMC7125695pubmed: 24908645google scholar: lookup
  5. Dunne HW, Huang CM, Lin WJ. Bovine enteroviruses in the calf: an attempt at serologic, biologic, and pathologic classification.. J Am Vet Med Assoc 1974 Feb 1;164(3):290-4.
    pubmed: 4359896
  6. Egbertson SH, Mayo DR. A microneutralization test for the identification of enterovirus isolates.. J Virol Methods 1986 Nov;14(3-4):305-7.
    doi: 10.1016/0166-0934(86)90032-7pubmed: 3025242google scholar: lookup
  7. Gür S, Tan M T, Özgünlük İ. Aydın ilinde sığırlarda bovine enterovirus (BEV) tip 1 ve 2’nin serolojik olarak araştırılmasi.. Pendik Vet. Mikrobiyol. Derg. 35: 3–6.
  8. Gür S, Akça Y, Burgu İ. Türkiye’de mandalarda bovine enterovirus tip-1’in serolojik olarak araştırılması.. Ankara Univ. Vet. Fak. Derg. 53: 191–194.
  9. Gür S, Yapkiç O, Yilmaz A. Serological survey of bovine enterovirus type 1 in different mammalian species in Turkey.. Zoonoses Public Health 2008;55(2):106-11.
    doi: 10.1111/j.1863-2378.2007.01095.xpubmed: 18234029google scholar: lookup
  10. Hamblin C, Knowles NJ, Hedger RS. Isolation and identification of bovid enteroviruses from free-living wild animals in Botswana.. Vet Rec 1985 Mar 2;116(9):238-9.
    doi: 10.1136/vr.116.9.238pubmed: 2988181google scholar: lookup
  11. He H, Tang C, Chen X, Yue H, Ren Y, Liu Y, Zhang B. Isolation and characterization of a new enterovirus F in yak feces in the Qinghai-Tibetan Plateau.. Arch Virol 2017 Feb;162(2):523-527.
    doi: 10.1007/s00705-016-3119-xpubmed: 27783166google scholar: lookup
  12. Jain N C, Batra S K. Isolation and characterisation of ovine enteroviruses.. Indian J. Virol. 1: 17–25.
  13. Jiménez-Clavero MA, Escribano-Romero E, Mansilla C, Gómez N, Córdoba L, Roblas N, Ponz F, Ley V, Sáiz JC. Survey of bovine enterovirus in biological and environmental samples by a highly sensitive real-time reverse transcription-PCR.. Appl Environ Microbiol 2005 Jul;71(7):3536-43.
    doi: 10.1128/AEM.71.7.3536-3543.2005pmc: PMC1168977pubmed: 16000759google scholar: lookup
  14. King A N Q, Brown F, Christian T, Hovi T, Hyypia T, Knowles N J, Lemon S M, Minor P D, Palmenberg A C, Skern T, Stanway G. Picornaviridae.. pp. 657–678. In: Virus Taxonomy, Seventh Report of the International Committee for the Taxonomy of Viruses (Van Regenmortel, M. H. V., Fauquet, C. M., Bishop, D. H. L., Calister, C. H., Carsten, E. B., Estes, M. K., Lemon, S. M., Maniloff, J., Mayo, M. A., McGeoch, D. J., Pringle, C. R., Wickner, R. B. eds.), Academic Press, San Diego..
  15. KUNIN CM, MINUSE E. The isolation in tissue culture, chick embryo and suckling mice of filtrable agents from healthy dairy cattle.. J Immunol 1958 Jan;80(1):1-11.
    pubmed: 13514066
  16. Knowles NJ, Barnett IT. A serological classification of bovine enteroviruses.. Arch Virol 1985;83(3-4):141-55.
    doi: 10.1007/BF01309912pubmed: 2578783google scholar: lookup
  17. Knowles N J, Mann J A. Bovine enteroviruses.. pp.513–516. In: Virus Infections of Ruminants (Dinter, Z. and Morein, B. eds.), Elsevier, Amsterdam..
  18. Kosoltanapiwat N, Yindee M, Chavez IF, Leaungwutiwong P, Adisakwattana P, Singhasivanon P, Thawornkuno C, Thippornchai N, Rungruengkitkun A, Soontorn J, Pearsiriwuttipong S. Genetic variations in regions of bovine and bovine-like enteroviral 5'UTR from cattle, Indian bison and goat feces.. Virol J 2016 Jan 25;13:13.
    doi: 10.1186/s12985-016-0468-8pmc: PMC4727389pubmed: 26811239google scholar: lookup
  19. Ley V, Higgins J, Fayer R. Bovine enteroviruses as indicators of fecal contamination.. Appl Environ Microbiol 2002 Jul;68(7):3455-61.
    doi: 10.1128/AEM.68.7.3455-3461.2002pmc: PMC126779pubmed: 12089028google scholar: lookup
  20. McClenahan SD, Scherba G, Borst L, Fredrickson RL, Krause PR, Uhlenhaut C. Discovery of a bovine enterovirus in alpaca.. PLoS One 2013;8(8):e68777.
    doi: 10.1371/journal.pone.0068777pmc: PMC3741315pubmed: 23950875google scholar: lookup
  21. McClurkin AW. Probable role of viruses in calfhood diseases.. J Dairy Sci 1977 Feb;60(2):278-82.
    doi: 10.3168/jds.S0022-0302(77)83865-4pmc: PMC7131618pubmed: 190279google scholar: lookup
  22. McFerran J B. Bovine enteroviruses.. Ann. N. Y. Acad. Sci. 101: 436–443.
    doi: 10.1111/j.1749-6632.1962.tb18883.xgoogle scholar: lookup
  23. MOLL T, FINLAYSON AV. Isolation of cytopathogenic viral agent from feces of cattle.. Science 1957 Aug 30;126(3270):401-2.
    doi: 10.1126/science.126.3270.401pubmed: 13467218google scholar: lookup
  24. MOSCOVICI C, LAPLACA M, MAISEL J, KEMPE H. Studies of bovine enteroviruses.. Am J Vet Res 1961 Sep;22:852-63.
    pubmed: 13773015
  25. Nollens HH, Rivera R, Palacios G, Wellehan JF, Saliki JT, Caseltine SL, Smith CR, Jensen ED, Hui J, Lipkin WI, Yochem PK, Wells RS, St Leger J, Venn-Watson S. New recognition of Enterovirus infections in bottlenose dolphins (Tursiops truncatus).. Vet Microbiol 2009 Oct 20;139(1-2):170-5.
    doi: 10.1016/j.vetmic.2009.05.010pmc: PMC4310689pubmed: 19581059google scholar: lookup
  26. Oberste MS, Schnurr D, Maher K, Al-Busaidy S, Pallansch MA. Molecular identification of new picornaviruses and characterization of a proposed enterovirus 73 serotype.. J Gen Virol 2001 Feb;82(Pt 2):409-416.
    doi: 10.1099/0022-1317-82-2-409pubmed: 11161280google scholar: lookup
  27. Pallansch M A, Roos R P. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses.. pp. 723–776. In: FieldsVirology, 4th ed. (Knipe, D. M., Howley, P. M., Griffin, D. E., Lamb, R. A., Martin, M. A., Roizman, B. and Straus, S. E. eds.), Lippincott Williams & Wilkins, Philadelphia..
  28. Peng XW, Dong H, Wu QM, Lu YL. Full genome sequence of a bovine enterovirus isolated in china.. Genome Announc 2014 Jun 26;2(3).
    doi: 10.1128/genomeA.00620-14pmc: PMC4073116pubmed: 24970832google scholar: lookup
  29. Puig M, Jofre J, Lucena F, Allard A, Wadell G, Girones R. Detection of adenoviruses and enteroviruses in polluted waters by nested PCR amplification.. Appl Environ Microbiol 1994 Aug;60(8):2963-70.
    pmc: PMC201750pubmed: 8085832doi: 10.1128/aem.60.8.2963-2970.1994google scholar: lookup
  30. Tsuchiaka S, Rahpaya SS, Otomaru K, Aoki H, Kishimoto M, Naoi Y, Omatsu T, Sano K, Okazaki-Terashima S, Katayama Y, Oba M, Nagai M, Mizutani T. Identification of a novel bovine enterovirus possessing highly divergent amino acid sequences in capsid protein.. BMC Microbiol 2017 Jan 17;17(1):18.
    doi: 10.1186/s12866-016-0923-0pmc: PMC5240211pubmed: 28095784google scholar: lookup
  31. Woo PC, Lau SK, Li T, Jose S, Yip CC, Huang Y, Wong EY, Fan RY, Cai JP, Wernery U, Yuen KY. A novel dromedary camel enterovirus in the family Picornaviridae from dromedaries in the Middle East.. J Gen Virol 2015 Jul;96(Pt 7):1723-31.
    doi: 10.1099/vir.0.000131pubmed: 25805410google scholar: lookup
  32. Yamada S. [Studies on bovine enteroviruses. IV. Neutralizing antibodies in the Kyushu district].. Nihon Juigaku Zasshi 1965 Dec;27(6):317-23.
    doi: 10.1292/jvms1939.27.317pubmed: 4298524google scholar: lookup
  33. Zell R, Krumbholz A, Dauber M, Hoey E, Wutzler P. Molecular-based reclassification of the bovine enteroviruses.. J Gen Virol 2006 Feb;87(Pt 2):375-385.
    doi: 10.1099/vir.0.81298-0pubmed: 16432025google scholar: lookup
  34. Zheng T. Characterisation of two enteroviruses isolated from Australian brushtail possums (Trichosurus vulpecula) in New Zealand.. Arch Virol 2007 Jan;152(1):191-8.
    doi: 10.1007/s00705-006-0838-4pmc: PMC7086802pubmed: 16906477google scholar: lookup
  35. Zhu L, Xing Z, Gai X, Li S, San Z, Wang X. Identification of a novel enterovirus E isolates HY12 from cattle with severe respiratory and enteric diseases.. PLoS One 2014;9(5):e97730.
    doi: 10.1371/journal.pone.0097730pmc: PMC4022658pubmed: 24830424google scholar: lookup

Citations

This article has been cited 6 times.
  1. Bohou Kombila L, N'dilimabaka N, Garcia D, Rieu O, Engone Ondo JD, Ndong Mebaley T, Boundenga L, Fritz M, Lenguiya LH, Maganga GD, Leroy EM, Becquart P, Mombo IM. Molecular Identification of Enteric Viruses in Domestic Animals in Northeastern Gabon, Central Africa. Animals (Basel) 2023 Aug 3;13(15).
    doi: 10.3390/ani13152512pubmed: 37570320google scholar: lookup
  2. Wróbel M, Małaczewska J, Kaczorek-Łukowska E. Antiviral Effect of Bovine Lactoferrin against Enterovirus E. Molecules 2022 Aug 29;27(17).
    doi: 10.3390/molecules27175569pubmed: 36080333google scholar: lookup
  3. Niendorf S, Harms D, Hellendahl KF, Heuser E, Böttcher S, Bock CT, Ulrich RG. Presence and Diversity of Different Enteric Viruses in Wild Norway Rats (Rattus norvegicus). Viruses 2021 May 26;13(6).
    doi: 10.3390/v13060992pubmed: 34073462google scholar: lookup
  4. Feng G, Kang T, Tang P, Xie C, Yan R, Qian W. Emergence of a Recombinant Bovine Enterovirus in China: Insights from Phylogenetic and Temporal Analysis. Animals (Basel) 2025 May 18;15(10).
    doi: 10.3390/ani15101457pubmed: 40427334google scholar: lookup
  5. Shi H, Wang L, Hu Y, Li G, Zhou M, Hui R, Ma L, Yao L. Enterovirus E infections in goats with respiratory disease. BMC Vet Res 2025 Feb 17;21(1):71.
    doi: 10.1186/s12917-025-04537-xpubmed: 39962514google scholar: lookup
  6. Doté J, Joffret ML, Beta BN, Ait-Ahmed M, Banga-Mingo V, Knowles NJ, Jouvenet N, MBaïkoua MN, Gouandjika-Vasilache I, Bessaud M. Characterization of enteroviruses circulating among farm animals and children in Central African Republic. Emerg Microbes Infect 2024 Dec;13(1):2368212.
    doi: 10.1080/22221751.2024.2368212pubmed: 38864685google scholar: lookup
Subscribe to our newsletter
Join 99,030 horse owners like you who receive our email updates on horse health and nutrition.